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ChemicalBook > CAS DataBase List > 2-Amino-5-bromo-6-methylpyridine

2-Amino-5-bromo-6-methylpyridine

Application
Product Name
2-Amino-5-bromo-6-methylpyridine
CAS No.
42753-71-9
Chemical Name
2-Amino-5-bromo-6-methylpyridine
Synonyms
5-BROMO-6-METHYLPYRIDIN-2-AMINE;6-AMINO-3-BROMO-2-PICOLINE;5-BROMO-6-METHYL-PYRIDIN-2-YLAMINE;ASISCHEM W51193;BUTTPARK 43\57-95;AKOS BBS-00004445;TIMTEC-BB SBB000260;6-Amino-3-bromo-2-methyL;2-AMINO-5-BROMO-6-PICOLINE;5-fluoro-2-pyridin-2-amine
CBNumber
CB8188979
Molecular Formula
C6H7BrN2
Formula Weight
187.04
MOL File
42753-71-9.mol
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2-Amino-5-bromo-6-methylpyridine Property

Melting point:
79-84 °C(lit.)
Boiling point:
234.3±35.0 °C(Predicted)
Density 
1.5672 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
4.80±0.37(Predicted)
form 
Fluffy Powder
color 
White to off-white
Sensitive 
Hygroscopic
BRN 
114140
InChI
InChI=1S/C6H7BrN2/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3,(H2,8,9)
InChIKey
SEOZHXRTVJPQPZ-UHFFFAOYSA-N
SMILES
C1(N)=NC(C)=C(Br)C=C1
CAS DataBase Reference
42753-71-9(CAS DataBase Reference)
EPA Substance Registry System
2-Pyridinamine, 5-bromo-6-methyl- (42753-71-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-26/37/39
WGK Germany 
3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
548405
Product name
6-Amino-3-bromo-2-methylpyridine
Purity
97%
Packaging
5g
Price
$48.7
Updated
2023/06/20
TCI Chemical
Product number
A1889
Product name
6-Amino-3-bromo-2-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$17
Updated
2025/07/31
TCI Chemical
Product number
A1889
Product name
6-Amino-3-bromo-2-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$66
Updated
2025/07/31
TRC
Product number
A594933
Product name
6-Amino-3-bromo-2-picoline
Packaging
500mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J54044
Product name
5-Bromo-6-methylpyridin-2-amine
Packaging
25g
Price
$33
Updated
2021/12/16
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2-Amino-5-bromo-6-methylpyridine Chemical Properties,Usage,Production

Application

2-Amino-5-bromo-6-methylpyridine is an important chemical raw material or intermediate, widely used in the synthesis of pyridine drugs, and also has potential effects such as antibacterial, antidepressant, insecticidal, herbicidal, and antimicrobial properties.

Chemical Properties

Light yellow Cryst

Synthesis

3430-17-9

42753-71-9

General steps: Example 2 Add 650 g of xylene as solvent to the reactor and heat to 115-120°C. The heating was continued under reflux conditions until the water was completely removed. The solvent was cooled to 70°C under nitrogen protection. Subsequently, 22 g of sodium amide was added and the solution was heated to 118-120 °C. Under reflux condition, 102 g of 2-bromo-3-methylpyridine was slowly added dropwise, and after completion of the dropwise addition, the reaction temperature was maintained at reflux for 1 hour. Upon completion of the reaction, the reaction solution was cooled to 45 °C. The reaction solution was then poured into ice water and the upper organic phase was separated. The xylene was concentrated under atmospheric pressure to 220 g remaining and cooled to 10-15 °C with stirring. After crystallization, 100 g of the target product 2-amino-5-bromo-6-methylpyridine was obtained with 99.3% purity and 90.1% yield.

References

[1] Patent: CN105348181, 2016, A. Location in patent: Paragraph 0023; 0024; 0025

2-Amino-5-bromo-6-methylpyridine Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 2-Amino-6-methylpyridine Ethyl acetate Bromine Dichloromethane Sodium hydroxide PETROLEUM ETHER Sulfuric acid

Preparation Products

2-ACETYLAMINO-5-BROMO-6-METHYLPYRIDINE 6-ACETAMIDO-3-BROMOPICOLINIC ACID
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2-Amino-5-bromo-6-methylpyridine Suppliers

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View Lastest Price from 2-Amino-5-bromo-6-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Amino-5-bromo-6-methylpyridine 42753-71-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Amino-5-bromo-6-methylpyridine 42753-71-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
2-Amino-5-bromo-6-methylpyridine 42753-71-9
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

42753-71-9, 2-Amino-5-bromo-6-methylpyridineRelated Search:

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  • C6H7BrN2
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Bromopyridines
  • Halopyridines
  • Heterocycle-Pyridine series
  • Amino-pyridine series
  • Halopyridines
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines, Pyrimidines, Purines and Pteredines
  • blocks
  • Bromides
  • Pyridines
  • Pyridine
  • Amines and Anilines
  • Heterocycles
  • Bromopyridines
  • Amines
  • compounds of pyridine