4-CHLOROTHIENO[2,3-D]PYRIMIDINE

Product Name: 4-CHLOROTHIENO[2,3-D]PYRIMIDINE
CAS No.: 14080-59-2
Chemical Name: 4-CHLOROTHIENO[2,3-D]PYRIMIDINE
Synonyms: BUTTPARK 48\18-41;4-CHLOROTHIENO[2,3-D]PYRIMIDINE;4-Chlorothienol[2,3-d]pyrimidine;Thieno[2,3-d]pyrimidine, 4-chloro-;4-CHLOROTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB8195193
Molecular Formula: C6H3ClN2S
Formula Weight: 170.62
MOL File: 14080-59-2.mol

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4-CHLOROTHIENO[2,3-D]PYRIMIDINE Property

Melting point:: 109-113°C
Boiling point:: 285.7±20.0 °C(Predicted)
Density: 1.531±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane, DMSO
form: Solid
pka: 0.42±0.40(Predicted)
color: Slightly Yellowish Crystalline
CAS DataBase Reference: 14080-59-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN2811
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C411500
Product name: 4-Chlorothieno[2,3-d]pyrimidine
Packaging: 5g
Price: $360
Updated: 2021/12/16

Usbiological

Product number: C5032-03
Product name: 4-Chlorothieno[2,3-d]pyrimidine
Packaging: 500mg
Price: $382
Updated: 2021/12/16

TRC

Product number: C411500
Product name: 4-Chlorothieno[2,3-d]pyrimidine
Packaging: 10g
Price: $690
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-5-W6
Product name: 4-Chlorothieno[2,3-d]pyrimidine
Packaging: 1g
Price: $28
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC09606
Product name: 4-Chlorothienol[2,3-d]pyrimidine
Packaging: 1g
Price: $60
Updated: 2021/12/16

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4-CHLOROTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Chemical Properties

Slightly Yellowish Crystalline Solid

Uses

4-Chlorothieno[2,3-d]pyrimidine (cas# 14080-59-2) is a compound useful in organic synthesis.

Definition

ChEBI: 4-Chlorothieno[2,3-d]pyrimidine is an organic heterobicyclic compound, an organonitrogen heterocyclic compound and an organosulfur heterocyclic compound.

Synthesis

14080-50-3

14080-59-2

General procedure for the synthesis of 4-chlorothieno[2,3-d]pyrimidine using thieno[2,3-d]pyrimidin-4(3H)-one as starting material: a solution of N,N-dimethylformamide (DMF, 1.53 mL, 19.7 mmol) in dichloromethane (50 mL) was cooled to 0 °C, oxalyl chloride (2.5 mL, 29.6 mmol) was slowly added, and the reaction system formed a A white gel-like substance was formed in the reaction system. Thieno[2,3-d]pyrimidin-4(3H)-one (1.5 g, 9.86 mmol) was then added and the reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and poured into water. The aqueous phase was extracted with dichloromethane, the organic phases were combined and dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=15:1) to afford 4-chlorothieno[2,3-d]pyrimidine as a white solid (1.61 g, 96% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3, 25 °C): δ= 8.88 (s, 1H, CH), 7.64 (d, J = 6.0 Hz, 1H, CH), 7.47 (d, J = 5.8 Hz, 1H, CH) ppm. high-resolution mass spectrometry (HRMS) analysis showed that the calculated value C6H4ClN2S [M]+ 170.97837, measured value 170.97804.

References

[1] Patent: US2012/46278, 2012, A1. Location in patent: Page/Page column 81
[2] Patent: US2014/88088, 2014, A1. Location in patent: Paragraph 1228-1230
[3] Tetrahedron Letters, 2007, vol. 48, # 30, p. 5261 - 5264
[4] Journal of Heterocyclic Chemistry, 2009, vol. 46, # 3, p. 459 - 464
[5] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 31 - 47

4-CHLOROTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLOROTHIENO[2,3-D]PYRIMIDINE Suppliers

Belgium 1 Canada 1 China 163 Germany 2 India 1 Japan 1 Ukraine 1 United Kingdom 8 United States 20 Global 198

Pure Chemistry Scientific Inc.

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View Lastest Price from 4-CHLOROTHIENO[2,3-D]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-CHLOROTHIENO[2,3-D]PYRIMIDINE 14080-59-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Honest Joy Holdings Limited

Product: 4-Chlorothieno[2,3-d]pyrimidine 14080-59-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 4-CHLOROTHIENO[2,3-D]PYRIMIDINE 14080-59-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 900kg
Release date: 2019-12-25

14080-59-2, 4-CHLOROTHIENO[2,3-D]PYRIMIDINERelated Search:

4-CHLOROTHIENO[2,3-D]PYRIMIDINE

BUTTPARK 48\18-41

4-Chlorothienol[2,3-d]pyrimidine

Thieno[2,3-d]pyrimidine, 4-chloro-

4-CHLOROTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH

14080-59-2

Heterocycle-Pyrimidine series

Nitrogen cyclic compounds

Halides

Nucleotides and Nucleosides

CHIRAL CHEMICALS

Bases & Related Reagents

Nucleotides

Fused Ring Systems