EC 3.4.22.1

Product Name: EC 3.4.22.1
CAS No.: 9047-22-7
Chemical Name: EC 3.4.22.1
Synonyms: CATHEPSIN B;EC 3.4.22.1;Cathepsin II;units/mg protein;Native Human Cathepsin B;Native Bovine Cathepsin B;CATHEPSIN B, BOVINE SPLEEN;CATHEPSIN B1, BOVINE SPLEEN;CATHEPSIN B FROM HUMAN LIVER;CATHEPSIN B FROM BOVINE SPLEEN
CBNumber: CB8206132
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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EC 3.4.22.1 Property

storage temp.: -70°C
solubility: H2O: soluble1.0mg/mL, clear
form: lyophilized powder
color: White to off-white

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Safety

Hazard Codes: B
WGK Germany: 3
RTECS: FI5725000
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6286
Product name: Cathepsin B from bovine spleen
Purity: lyophilized powder, ≥10?units/mg protein
Packaging: 10units
Price: $203
Updated: 2024/03/01

Sigma-Aldrich

Product number: C6286
Product name: Cathepsin B from bovine spleen
Purity: lyophilized powder, ≥10?units/mg protein
Packaging: 25units
Price: $403
Updated: 2024/03/01

Sigma-Aldrich

Product number: C8571
Product name: Cathepsin B from human liver
Purity: buffered aqueous solution, ≥1,500?units/mg protein (E1%/280)
Packaging: 25μg
Price: $468
Updated: 2024/03/01

Sigma-Aldrich

Product number: C6286
Product name: Cathepsin B from bovine spleen
Purity: lyophilized powder, ≥10?units/mg protein
Packaging: 100units
Price: $1200
Updated: 2024/03/01

Sigma-Aldrich

Product number: C0150
Product name: Cathepsin B from human placenta
Purity: lyophilized powder, ≥5?units/mg protein
Packaging: 2units
Price: $86.8
Updated: 2024/03/01

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EC 3.4.22.1 Chemical Properties,Usage,Production

Uses

Cathepsin B from human liver has been used:

as a positive control in the screening Cathepsin B inhibitor assay
in wall extension (expansin activity) assay
in microinjection human foreskin fibroblasts to test its effect on apoptosis induction

Uses

Cathepsin B is a lysosomal cysteine proteinase which hydrolyzes proteins with a broad specificity for peptide bonds. Cathepsin B may be a useful tool in Alzheimer′s research, as it may have a role in the natural defense against the disease . Cathepsin B may be used to cleave procaspase 1 and procaspase 11, and to induce apoptosis in digitonin-permeabilized cells.

General Description

Cathepsin B gene is mapped to human chromosome 8p23.1. It is a lysosomal cysteine with 252 amino acids distributed in two chains and is homologous to rat liver sequence. It has disc shaped structure with two domains namely the left-hand ′L′ domain at the amino terminal and right hand ′R′ domain at the carboxyl-terminal.

Biochem/physiol Actions

Cathepsin B displays an endopeptidase and peptidyl dipeptidase activities. It may be associated with the pathophysiology of tumors. Cathepsin B is also regarded as a prominent protease in Leishmaniasis. It is overactivated in muscular dystrophy, pulmonary emphysema, and bone resorption.

Purification Methods

Cathepsin B is purified by affinity chromatography on the semicarbazone of Gly-Phe-glycinal-linked to Sepharose 4B, with elution by 2,2'-dipyridyl disulfide [Rich et al. Biochem J 235 731 1986, Methods Enzymol 80 551 1981].

EC 3.4.22.1 Preparation Products And Raw materials

Raw materials

Preparation Products

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EC 3.4.22.1 Suppliers

China 24 Europe 2 Germany 1 Japan 1 Switzerland 1 United Kingdom 1 United States 6 Global 36

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9047-22-7, EC 3.4.22.1Related Search:

CATHEPSIN D SUC-ALA-ALA-PRO-PHE-PNA EC 3.4.14.1 CATHEPSIN G FROM HUMAN LEUKOCYTES Ethyl isocyanoacetate SALCOMINE COBALT(II) ACETYLACETONATE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide Tris(2,4-pentanedionato)chroMiuM(III) Cupric acetylacetonate N-BUTYLISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate EC 3.4.22.1

CATHEPSIN B

CATHEPSIN B1, BOVINE SPLEEN

CATHEPSIN B, BOVINE SPLEEN

EC 3.4.22.1

CATHEPSIN B FROM HUMAN LIVER

CathepsinB from human placenta,CathepsinB1

CathepsinB from bovine spleen,Cathepsin B1

CATHEPSIN B FROM HUMAN PLACENTA

CATHEPSIN B FROM BOVINE SPLEEN

CathepsinB from human liver,CathepsinB1

Cathepsin II

Cathepsin B from Human, recombinant

Native Human Cathepsin B

Native Bovine Cathepsin B

units/mg protein

9047-22-7

Enzymes

Proteins and Peptides

Cathepsins and Granzymes

Cell Signaling and Neuroscience

Cell Biology

Apoptosis and Cell Cycle

Cancer Research

Cancer Markers and Antibodies

BioChemical