CATHEPSIN D

Product Name: CATHEPSIN D
CAS No.: 9025-26-7
Chemical Name: CATHEPSIN D
Synonyms: CATHEPSIN D;EC 3.4.23.5;EC 3.4.22.5;Cathepsins D;CATHEPSIN D, HUMAN;CATHEPSIN D, BOVINE;CATHEPSIN D, HUMAN LIVER;Native Human Cathepsin D;CATHEPSIN D, HUMAN SPLEEN;Native Bovine Cathepsin D
CBNumber: CB9265367
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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CATHEPSIN D Property

storage temp.: -20°C
form: lyophilized powder
color: white
Water Solubility: Reconstitute in water at 1µg/µl

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C3138
Product name: Cathepsin D from bovine spleen
Purity: lyophilized powder, ≥2.0?units/mg protein
Packaging: 5UNITS
Price: $289
Updated: 2024/03/01

Sigma-Aldrich

Product number: C8696
Product name: Cathepsin D from human liver
Purity: lyophilized powder, ≥250?units/mg protein (E1%/280)
Packaging: 25μg
Price: $373
Updated: 2024/03/01

Sigma-Aldrich

Product number: C3138
Product name: Cathepsin D from bovine spleen
Purity: lyophilized powder, ≥2.0?units/mg protein
Packaging: 10UNITS
Price: $493
Updated: 2024/03/01

Sigma-Aldrich

Product number: C3138
Product name: Cathepsin D from bovine spleen
Purity: lyophilized powder, ≥2.0?units/mg protein
Packaging: 20UNITS
Price: $875
Updated: 2024/03/01

Sigma-Aldrich

Product number: C3138
Product name: Cathepsin D from bovine spleen
Purity: lyophilized powder, ≥2.0?units/mg protein
Packaging: 40UNITS
Price: $1540
Updated: 2023/01/07

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CATHEPSIN D Chemical Properties,Usage,Production

Uses

Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer.

Uses

Cathepsin D from human liver has been used:

in β-secretase activity assay
for enzymatic degradation of amyloid β 1-42
in microinjection of human foreskin fibroblasts

General Description

Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis.

Biochem/physiol Actions

Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.

Purification Methods

Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960].

CATHEPSIN D Preparation Products And Raw materials

Raw materials

Preparation Products

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CATHEPSIN D Suppliers

China 20 Europe 2 Germany 2 Japan 1 Switzerland 1 United Kingdom 1 United States 8 Global 35

Sigma-Aldrich

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Maclean Biochemical Technology Co., LTD

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Biolab Reagents

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Shanghai Guchen Biotechnology Co., LTD

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ACROBiosystems

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Creative Enzymes

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9025-26-7, CATHEPSIN DRelated Search:

EC 3.4.14.1 EC 3.4.22.1 CATHEPSIN G FROM HUMAN LEUKOCYTES Ethyl isocyanoacetate 2,4-PENTANEDIONE, SILVER DERIVATIVE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Benzyl isocyanide PHENYLSELENOL Cupric acetylacetonate COBALT(II) ACETYLACETONATE SALCOMINE METHYL ISOCYANOACETATE Aluminum acetylacetonate

CATHEPSIN D

CATHEPSIN D, BOVINE

CATHEPSIN D, BOVINE KIDNEY

CATHEPSIN D, BOVINE SPLEEN

CATHEPSIN D, HUMAN

CATHEPSIN D, HUMAN LIVER

CATHEPSIN D, HUMAN SPLEEN

EC 3.4.22.5

EC 3.4.23.5

Cathepsins D

CATHEPSIN D, FROM HUMAN LIVER

CATHEPSIN D FROM BOVINE SPLEEN

Cathepsin D from Human, recombinant

Native Human Cathepsin D

Native Bovine Cathepsin D

9025-26-7

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