ChemicalBook > CAS DataBase List > Bromelain

Bromelain

Product Name
Bromelain
CAS No.
9001-00-7
Chemical Name
Bromelain
Synonyms
bromelains;CATHEPSIN B1;ananase;BROMELIN;3.4.22.32;BROMELAIN;Edemase D;Bromezyme;Bromelein;BROMELASIN
CBNumber
CB1699687
Molecular Formula
N/A
Formula Weight
0
MOL File
Mol file
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Bromelain Property

storage temp. 
−20°C
form 
powder
color 
yellow-brown
Water Solubility 
soluble
CAS DataBase Reference
9001-00-7
EPA Substance Registry System
Bromelain, juice (9001-00-7)
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Safety

Hazard Codes 
B,Xn
Risk Statements 
36/37/38-42
Safety Statements 
22-24-26-36/37-36/37/39
WGK Germany 
3
10-21
HS Code 
35079090
Hazardous Substances Data
9001-00-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B678540
Product name
Bromelain,TechnicalGrade
Packaging
10g
Price
$340
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001764
Product name
BROMELAIN
Purity
95.00%
Packaging
10G
Price
$1147.74
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001764
Product name
BROMELAIN
Purity
95.00%
Packaging
25G
Price
$1189.59
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001764
Product name
BROMELAIN
Purity
95.00%
Packaging
100G
Price
$2763.25
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
68199
Product name
Bromelain
Packaging
1g
Price
$290
Updated
2021/12/16
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Bromelain Chemical Properties,Usage,Production

Description

Bromelains (Ananase) is a mixture of proteolyticenzymes obtained from the pineapple plant. It isproposed for use in the treatment of soft-tissue inflammationand edema associated with traumatic injury, localized inflammation,and postoperative tissue reactions.

Chemical Properties

White to light brownish yellow amorphous powder.
Soluble in water,insoluble in ethanol, chloroform and ether.

Uses

Bromelain is used as a natural anti-inflammatory for conditions such as arthritis.

Definition

ChEBI: Bromelain is a milk-clotting proteolytic enzyme. It is precipitated from pineapple juice with acetone or ammonium sulfide. Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.

Uses

Bromelain has been found to be used to tenderize meat, chill-proof beer, and produce protein hydrolysates.

Preparation

Bromelain is prepared from the juice of cooled pineapple through ultrafiltration, centrifugation, and lyophilization, which results in the production of a yellow powder. This process can succeed in a wide range of pH values.

General Description

Bromelain is a crude extract from pineapple that contains a mixture of different proteases as well as phosphatases, glucosidases, peroxidases, cellulases, glycoproteins, and carbohydrates. Of the different proteases available in a bromelain mixture, commercial bromelain is usually produced from the stem part (stem bromelain), although other pineapple parts contain a certain amount of bromelain as well. Bromelain is an effective anticancer therapeutic agent, as a result of the systemic response to multiple cellular and molecular targets induced by this enzyme; however, the real underlying mechanisms are yet to be fully understood. Also, this enzyme has the potential to be used as an antibiotic since it can modify the permeability of organs and tissues to different drugs. Moreover, bromelain is used in a debridement cream formulation to eliminate burn debris and accelerate the healing process, and can inhibit platelet aggregation, especially for patients affected with heart attack and stroke, and reduce arthritis pathogenesis since it has analgesic properties that can influence pain mediators, and prevent diarrhea by interacting with intestinal secretory signaling pathways. In addition to food and medical applications, bromelain is used in the cosmetic industry to treat various skin conditions. It is also used as a stain remover in teeth cleaning/whitening. In the textile industry, it is used to improve the dyeing properties of protein fibers such as wool and silk and assist in the cocoon-softening process in silk production.

Application

Baking Industry: In the baking industry, bromelain is used for improving dough quality and rise. Gluten is a major component of wheat. As Gluten is insoluble in water, it forms a lattice-like structure. Bromelain removes gluten from wheat, ensuring proper dough formation. Bromelain is also used to produce flour of hypoallergic nature.
Catering:Bromelain helps in the hydrolysis of myofibril proteins in meat, chicken, and oyster. The protease activity of the enzyme bromelain breaks collagen fiber leading to meat tenderization process. The sulfhydryl group of cysteine in the protease is responsible for the proteolytic action of collagen fiber, leading to the process of tenderization that makes the meat more palatable.
Alcohol supply: Bromelain is used for enhancing the stability of the protein and preventing haziness in beer. Bromelain enhances the stability of the white-wine protein. The bromelain isolated from the stem was active at the minimum pH value of wine and showed an increase in the Ka value by 42%, acting as an alcoholic-acid buffer and thereby acting as an excellent protease enzyme in the production and stabilization of wine.
Cosmetic: Bromelain can be used to treat acne and wrinkles, and to reduce swelling, bruising and drying of the skin. Bromelain proteolyses the protein of the upper layer of skin cells, paving a way for the replacement of young cells. The study also reports that the application of bromelain on the skin reduces the bruises caused during cosmetic surgeries.

Mechanism of action

The major action of bromelain appears to be proteolytic in nature, although evidence also suggests an immunomodulatory and hormone-like activity acting via intracellular signaling pathways. Bromelain has been shown to reduce cell surface receptors, such as hyaluronan receptor CD44, which is associated with leukocyte migration and induction of proinflammatory mediators. Additionally, it is also reported to significantly reduce CD4 + T-cell infiltrations, which are primary effectors in animal models of inflammation in the gut. It has been found to be effective in improvement of clinical and histologic severity of colonic inflammation in a murine colitis model of IL-10-deficient mice[1].

References

[1] Salibay, Cristina C., et al. "Natural product–derived drugs for the treatment of inflammatory bowel diseases (IBD)." Inflammation and Natural Products (2021).

Bromelain Preparation Products And Raw materials

Raw materials

Preparation Products

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Bromelain Suppliers

Hunan Century Huaxing Biological Engineering Co., LTD
Tel
13549689901
Email
569673424@qq.com
Country
China
ProdList
55
Advantage
58
Shanghai Linchen Pharmaceutical Technology co.,LTD
Tel
021-31606595 13761181955
Email
info@linchenpharm.com
Country
China
ProdList
144
Advantage
58
ZHEJLANG HUADI PHARMACEUTICAL GROUP CO, LTD.
Tel
15394211517 18339827871
Email
429129990@qq.com
Country
China
ProdList
55
Advantage
58
Zhengbainian (Shanghai) International Trade Co., Ltd.
Tel
13381511189
Email
juetubt1988@163.com
Country
China
ProdList
411
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
973
Advantage
55
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View Lastest Price from Bromelain manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Bromelain 9001-00-7
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
99%
Supply Ability
20tons
Release date
2023-12-23
Sinoway Industrial co., ltd.
Product
Bromelain 9001-00-7
Price
US $130.00-85.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
95%
Supply Ability
20 tons
Release date
2023-12-25
Nantong Guangyuan Chemicl Co,Ltd
Product
Bromelain 9001-00-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-12-01

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