5-Nitrobenzothiophene

Product Name: 5-Nitrobenzothiophene
CAS No.: 4965-26-8
Chemical Name: 5-Nitrobenzothiophene
Synonyms: 5-nitrobenzo[b]thiophene;5-NITROBENZOTHIOPHENE;5-nitro-1-benzothiophene;Benzo[b]thiophene, 5-nitro-;5-Nitrobenzothiophene ISO 9001：2015 REACH
CBNumber: CB8208222
Molecular Formula: C8H5NO2S
Formula Weight: 179.2
MOL File: 4965-26-8.mol

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5-Nitrobenzothiophene Property

Melting point:: 149-150 °C
Boiling point:: 324.6±15.0 °C(Predicted)
Density: 1.435±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N495033
Product name: 5-Nitrobenzo[b]thiophene
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W006433
Product name: 5-Nitrobenzo[b]thiophene
Purity: ≥98.0%
Packaging: 250mg
Price: $61
Updated: 2021/12/16

Apolloscientific

Product number: OR938440
Product name: 5-Nitrobenzothiophene
Purity: 95%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: Y9213
Product name: 5-Nitrobenzo[b]thiophene
Packaging: 250mg
Price: $154
Updated: 2021/12/16

ChemScene

Product number: CS-W006433
Product name: 5-Nitrobenzo[b]thiophene
Purity: ≥98.0%
Packaging: 5g
Price: $188
Updated: 2021/12/16

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5-Nitrobenzothiophene Chemical Properties,Usage,Production

Synthesis

6345-55-7

4965-26-8

5-Nitro-1-benzothiophene-2-carboxylic acid (40 g, 179 mmol) was dissolved in quinoline (350 mL) under mechanical stirring followed by addition of copper powder (11.3 g, 179 mmol). The reaction mixture was heated to 190°C until complete gas release. After completion of the reaction, the mixture was cooled to room temperature and poured into crushed ice and acidified with concentrated hydrochloric acid. The resulting suspension was extracted with ethyl acetate and the organic layer was separated and washed sequentially with 2N hydrochloric acid, water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated to give 5-nitrobenzothiophene (30.5 g, 95% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz) and LC-MS (electrospray): 1H NMR δ 8.85 (d, 1H), 8.31 (d, 1H), 8.18 (dd, 1H), 8.06 (d, 1H), 7.73 (d, 1H); LC-MS m/z = 180 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 403 - 427
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 8, p. 735 - 740
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 338 - 343
[4] Patent: WO2006/66172, 2006, A1. Location in patent: Page/Page column 27
[5] Synthetic Communications, 1991, vol. 21, # 7, p. 959 - 964

5-Nitrobenzothiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Nitrobenzothiophene Suppliers

Belgium 1 China 64 Germany 1 India 1 Switzerland 1 United Kingdom 6 United States 12 Global 86

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
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Advantage: 57

Wuhan Haizheng Industry & Trade Development Co. Ltd

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Bide Pharmatech Ltd.

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Zhengzhou Alfachem Co., Ltd.

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Yancheng KangdiSen Pharmaceutical Co., Ltd.

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Henan CoreyChem Co., Ltd

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Shanghai YuanYe Biotechnology Co., Ltd.

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Fax: QQ:3008007432
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Amadis Chemical Company Limited

Tel: 571-89925085
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Country: China
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Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2944
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View Lastest Price from 5-Nitrobenzothiophene manufacturers

Career Henan Chemical Co

Product: 5-Nitrobenzothiophene 4965-26-8
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/T
Release date: 2019-12-24

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4965-26-8

C8H5NO2S