2',5'-Dihydroxyacetophenone
- Product Name
- 2',5'-Dihydroxyacetophenone
- CAS No.
- 490-78-8
- Chemical Name
- 2',5'-Dihydroxyacetophenone
- Synonyms
- 2,5-DIHYDROXYACETOPHENONE;1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE;1-(2,5-DIHYDROXYPHENYL)ETHANONE;Ethanone, 1-(2,5-dihydroxyphenyl)-;2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one;2,5-DHAP;ACETYLQUINOL;WLN: QR CQ BV1;QUINACETOPHENONE;Acetylhydroquinone
- CBNumber
- CB8221168
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 490-78-8.mol
2',5'-Dihydroxyacetophenone Property
- Melting point:
- 204-206 °C(lit.)
- Boiling point:
- 234.6°C (rough estimate)
- Density
- 1.2143 (rough estimate)
- refractive index
- 1.4447 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- dioxane: 50 mg/mL, clear
- pka
- 9.86±0.18(Predicted)
- form
- Crystals or Crystalline Powder
- color
- Yellow to yellow-green
- Water Solubility
- insoluble
- BRN
- 637903
- InChIKey
- WLDWSGZHNBANIO-UHFFFAOYSA-N
- LogP
- 1.274 (est)
- CAS DataBase Reference
- 490-78-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8)
- EPA Substance Registry System
- Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D107603
- Product name
- 2′,5′-Dihydroxyacetophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $70.8
- Updated
- 2024/03/01
- Product number
- 8.18284
- Product name
- 2′,5′-Dihydroxyacetophenone
- Purity
- for synthesis
- Packaging
- 10g
- Price
- $97.2
- Updated
- 2024/03/01
- Product number
- 8.18284
- Product name
- 2',5'-Dihydroxyacetophenone for synthesis. CAS 490-78-8, chemical formula 2,5-(OH) -C H COCH ., for synthesis
- Packaging
- 8182840010
- Price
- $74.7
- Updated
- 2021/12/16
- Product number
- D1955
- Product name
- 2',5'-Dihydroxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $54
- Updated
- 2024/03/01
- Product number
- D1955
- Product name
- 2',5'-Dihydroxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $187
- Updated
- 2024/03/01
2',5'-Dihydroxyacetophenone Chemical Properties,Usage,Production
Description
2',5'-Dihydroxyacetophenone is a natural phenolic compound that is found in many plants. It has been shown to have anti-inflammatory properties through its ability to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1 beta.
Chemical Properties
yellow to yellow-green crystals or
Uses
1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.
Uses
2',5'-Dihydroxyacetophenone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.
Preparation
Preparation by Fries rearrangement of hydroquinone diacetate,
with aluminium chloride(91%) (76%)(63–77%) (55–60%)
with zinc chloride in refluxing acetic acid (quantitative yield)
with boron trifluoride etherate in benzene at reflux (65%).
Application
2',5'-Dihydroxyacetophenone inhibits the formation of reactive oxygen species and nitric oxide in rat neutrophils. It also has the ability to reduce oxidative stress by scavenging free radicals and inhibiting lipid peroxidation. The underlying mechanism for these effects is not fully understood but may be due to its ability to act as a substrate for matrix-assisted laser desorption ionization (MALDI). This means that it can react with protocatechuic acid molecules that are present in the sample preparation chamber, leading to polymerase chain reaction (PCR) amplification.
Definition
ChEBI: 2',5'-Dihydroxyacetophenone is an aromatic ketone.
Synthesis Reference(s)
The Journal of Organic Chemistry, 18, p. 1709, 1953 DOI: 10.1021/jo50018a014
2',5'-Dihydroxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2',5'-Dihydroxyacetophenone manufacturers
- Product
- 2',5'-Dihydroxyacetophenone 490-78-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-10-29
- Product
- 2',5'-Dihydroxyacetophenone 490-78-8
- Price
- US $10.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- 2',5'-Dihydroxyacetophenone 490-78-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-25