2',5'-Dihydroxyacetophenone

ChemicalBook > CAS DataBase List > 2',5'-Dihydroxyacetophenone

2',5'-Dihydroxyacetophenone

Product Name: 2',5'-Dihydroxyacetophenone
CAS No.: 490-78-8
Chemical Name: 2',5'-Dihydroxyacetophenone
Synonyms: 2,5-DIHYDROXYACETOPHENONE;1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE;1-(2,5-DIHYDROXYPHENYL)ETHANONE;Ethanone, 1-(2,5-dihydroxyphenyl)-;2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one;2,5-DHAP;ACETYLQUINOL;WLN: QR CQ BV1;QUINACETOPHENONE;Acetylhydroquinone
CBNumber: CB8221168
Molecular Formula: C8H8O3
Formula Weight: 152.15
MOL File: 490-78-8.mol

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2',5'-Dihydroxyacetophenone Property

Melting point:: 204-206 °C(lit.)
Boiling point:: 234.6°C (rough estimate)
Density: 1.2143 (rough estimate)
refractive index: 1.4447 (estimate)
storage temp.: Store below +30°C.
solubility: dioxane: 50 mg/mL, clear
pka: 9.86±0.18(Predicted)
form: Crystals or Crystalline Powder
color: Yellow to yellow-green
Water Solubility: insoluble
BRN: 637903
InChIKey: WLDWSGZHNBANIO-UHFFFAOYSA-N
LogP: 1.274 (est)
CAS DataBase Reference: 490-78-8(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8)
EPA Substance Registry System: Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: AM7700000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29145000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D107603
Product name: 2′,5′-Dihydroxyacetophenone
Purity: 97%
Packaging: 25g
Price: $70.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18284
Product name: 2′,5′-Dihydroxyacetophenone
Purity: for synthesis
Packaging: 10g
Price: $97.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18284
Product name: 2',5'-Dihydroxyacetophenone for synthesis. CAS 490-78-8, chemical formula 2,5-(OH) -C H COCH ., for synthesis
Packaging: 8182840010
Price: $74.7
Updated: 2021/12/16

TCI Chemical

Product number: D1955
Product name: 2',5'-Dihydroxyacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $54
Updated: 2024/03/01

TCI Chemical

Product number: D1955
Product name: 2',5'-Dihydroxyacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $187
Updated: 2024/03/01

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2',5'-Dihydroxyacetophenone Chemical Properties,Usage,Production

Description

2',5'-Dihydroxyacetophenone is a natural phenolic compound that is found in many plants. It has been shown to have anti-inflammatory properties through its ability to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1 beta.

Chemical Properties

yellow to yellow-green crystals or

Uses

1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.

Uses

2',5'-Dihydroxyacetophenone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.

Preparation

Preparation by Fries rearrangement of hydroquinone diacetate,
with aluminium chloride(91%) (76%)(63–77%) (55–60%)
with zinc chloride in refluxing acetic acid (quantitative yield)
with boron trifluoride etherate in benzene at reflux (65%).

Application

2',5'-Dihydroxyacetophenone inhibits the formation of reactive oxygen species and nitric oxide in rat neutrophils. It also has the ability to reduce oxidative stress by scavenging free radicals and inhibiting lipid peroxidation. The underlying mechanism for these effects is not fully understood but may be due to its ability to act as a substrate for matrix-assisted laser desorption ionization (MALDI). This means that it can react with protocatechuic acid molecules that are present in the sample preparation chamber, leading to polymerase chain reaction (PCR) amplification.

Definition

ChEBI: 2',5'-Dihydroxyacetophenone is an aromatic ketone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1709, 1953 DOI: 10.1021/jo50018a014

2',5'-Dihydroxyacetophenone Preparation Products And Raw materials

Raw materials

1,4-Diacetoxybenzene Aluminium chloride hexahydrate

Preparation Products

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View Lastest Price from 2',5'-Dihydroxyacetophenone manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2',5'-Dihydroxyacetophenone 490-78-8
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-12-18

Hebei Mujin Biotechnology Co.,Ltd

Product: 2',5'-Dihydroxyacetophenone 490-78-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-25

Hebei Weibang Biotechnology Co., Ltd

Product: 2',5'-Dihydroxyacetophenone 490-78-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-10-29

490-78-8, 2',5'-DihydroxyacetophenoneRelated Search:

2',4'-Dichloroacetophenone 4'-Hydroxyacetophenone 3-Nitroacetophenone PIPERACETAZINE (250 MG) DIHYDROXYACETOPHENONE,DIHYDROXYACETOPHENONE,3,4-,3',4'-DIHYDROXYACETOPHENONE,3,4-DIHYDROXYACETOPHENONE,3,4-Dihydroxyacetophenone 3',4'-Dihydroxyacetophenone 3-Aminoacetophenone 4-Nitroacetophenone 2-HYDROXYACETOPHENONE 2-Bromoacetophenone Acetophenone 2'-Hydroxyacetophenone 3'-Hydroxyacetophenone 4'-Bromoacetophenone 2'-Hydroxy-5'-methoxyacetophenone 5,8-Dihydroxy-1,4-naphthoquinone 3',5'-Dihydroxyacetophenone 3,5-Dihydroxyacetophenone,3',5'-DIHYDROXYACETOPHENONE,3,5-DIHYDROXYACETOPHENONE MONOHYDRATE,3,5-DIHYDROXYACETOPHENONE 2',6'-Dihydroxyacetophenone 2-BROMO-2',5'-DIMETHOXYACETOPHENONE

1-(2,5-dihydroxyphenyl)-ethanon

1-Acetyl-2,5-dihydroxybenzene

2,5-Dihydroxy-1-acetylbenzene

2’,5’-dihydroxy-acetophenon

Acetophenone, 2',5'-dihydroxy-

Acetylhydroquinone

QUINACETOPHENONE

2-Acetylhydroquinone Quinacetophenone

2',5'-DIHYDROXYACETOPHENONE FOR SYNTHESI

1-(2,5-Dihydroxyphenyl)ethan-1-one, 2-Acetylhydroquinone

2,5- twohydroxyAcetophenone

WLN: QR CQ BV1

ACETYLQUINOL

2,5-DIHYDROXYPHENYL METHYL KETONE

2,5-DIHYDROXYACETOPHENONE

2-ACETYL-1,4-DIHYDROXYBENZENE

2-ACETYLHYDROQUINONE

1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE

1-(2,5-DIHYDROXYPHENYL)ETHANONE

2',5'-Dihydroxyacetophenone 2-Acetylhydroquinone

2,5-Dihydroxyacetophenone, 98+%

2-Acethylhydroquinone

Ethanone, 1-(2,5-dihydroxyphenyl)-

2,5-DIHYDROXYACETOPHENONE extrapure

2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone

2',5'-Dihydroxyacetophenone,97%

2',5'- Dihydroxyacetophnone

2′,5′-Dihydroxyacetophenone,2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone

2',5'-Dihydroxyaceto

2 ', 5'-hydroxyacetophenone

5'-Dihydroxyacetophenone

2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one

2',5'-Dihydroxyacetophenone&gt

2,5-DHAP

2,5-Dihydroxy-Acetophenone (Quinacetophenone -98 %)

2',5'- Di hyfeoxy acetophenone

2',5'-Dihydroxyacetophenone(Quinactophenone)

2',5'-Dihydroxyacetophenone, ≥ 98.0%

2',5'-Dihydroxyacetophenone

2,5-Dihydroxyacetophenone, 10 mM in DMSO

490-78-8

490-78-9

HO2C6H3COCH3

BioChemical

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C7 to C8

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Organic Building Blocks

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KETONE

Building Blocks

C7 to C8

Carbonyl Compounds

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