ChemicalBook > CAS DataBase List > 3,5-Dichloro-2-cyanopyridine

3,5-Dichloro-2-cyanopyridine

Product Name
3,5-Dichloro-2-cyanopyridine
CAS No.
85331-33-5
Chemical Name
3,5-Dichloro-2-cyanopyridine
Synonyms
3,5-dichloropicolinonitrile;3,5-Dichloropyridine-2-carbonitrile;3,5-Dichloropicolinitrile;3,5-DICHLORO-2-CYANOPYRIDINE;2-CYANO-3,5-DICHLOROPYRIDINE;Cyanodichloropyridine 235---;3,5-dichboro-2-cyanopyridine;3,5-Dichloror-2-cyanopyridine;3,5-Dichloro-2-cyanopyridine>3,5-Dichloro-pyridin-2-carbonitrile
CBNumber
CB8232724
Molecular Formula
C6H2Cl2N2
Formula Weight
173
MOL File
85331-33-5.mol
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3,5-Dichloro-2-cyanopyridine Property

Melting point:
101-103°C
Boiling point:
271.9±35.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-4.61±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow
BRN 
4390101
InChI
InChI=1S/C6H2Cl2N2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H
InChIKey
ATUOLSDAAPMVJJ-UHFFFAOYSA-N
SMILES
C1(C#N)=NC=C(Cl)C=C1Cl
CAS DataBase Reference
85331-33-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39-36-36/37
RIDADR 
3439
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
736074
Product name
3,5-Dichloropyridine-2-carbonitrile
Purity
95%
Packaging
1g
Price
$30.7
Updated
2023/01/07
Sigma-Aldrich
Product number
736074
Product name
3,5-Dichloropyridine-2-carbonitrile
Purity
95%
Packaging
5g
Price
$61.9
Updated
2023/01/07
TCI Chemical
Product number
D4059
Product name
3,5-Dichloro-2-cyanopyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
D4059
Product name
3,5-Dichloro-2-cyanopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$73
Updated
2025/07/31
TRC
Product number
D473985
Product name
3,5-Dichloropicolinonitrile
Packaging
500mg
Price
$45
Updated
2021/12/16
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3,5-Dichloro-2-cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow to light brown crystalline powder

Uses

3,5-Dichloro-2-cyanopyridine is an intermediate in the industrial synthesis of nicotinic acid and nicotinamide.

Synthesis

15177-57-8

7677-24-9

85331-33-5

General procedure for the synthesis of 2-cyano-3,5-dichloropyridine from 3,5-dichloropyridine 1-oxide and trimethylcyanosilane: 21.8 mL (0.174 mol) of trimethylcyanosilane and 14.6 mL (0.158 mol) of dimethylcarbamoyl chloride were sequentially added to 26 g (0.158 mol) of 3,5-dichloropyridine 1-oxide in an 80-mL dichloromethane solution. The reaction mixture was stirred at room temperature for 48 hours. After the reaction was completed, 100 mL of 10% aqueous NaHCO3 solution was added and stirred vigorously for 10 minutes. After separating the organic and aqueous phases, the aqueous phase was extracted once with dichloromethane. All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using dichloromethane as eluent. The target fraction was collected, concentrated and recrystallized from a small amount of methanol to give 11 g (40.2% yield) of 2-cyano-3,5-dichloropyridine with a melting point of 102 °C. The target fraction was collected, concentrated and recrystallized from a small amount of methanol.

References

[1] Patent: US2003/232842, 2003, A1. Location in patent: Page 8

3,5-Dichloro-2-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Dichloro-2-cyanopyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3,5-Dichloro-2-cyanopyridine 85331-33-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Jinan Finer Chemical Co., Ltd
Product
3,5-Dichloro-2-cyanopyridine 85331-33-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100mt
Release date
2021-11-23
Hebei Zhuanglai Chemical Trading Co Ltd
Product
3,5-Dichloro-2-cyanopyridine 85331-33-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-18

85331-33-5, 3,5-Dichloro-2-cyanopyridineRelated Search:

2,3-Dichloropyridine 2,5-Dichloropyridine 2-Cyanopyridine 3-Aminopyridine Clopyralid 2-Chloro-5-chloromethylpyridine 3,5-Dichloropyridine 5-Bromo-3-nitropyridine-2-carbonitrile 2-Cyano-3-fluoropyridine 5-bromo-3-methylpicolinonitrile 2-Cyano-3-chloropyridine 2-Cyano-3,5-difluoropyridine 3-bromo-5-chloropyridine-2-carbonitrile 5-bromo-3-chloropyridine-2-carbonitrile 2-Cyano-3-trifluoromethylpyridine 5-Chloro-3-nitropyridine-2-carbonitrile 5-Bromo-3-fluoro-pyridine-2-carbonitrile 3-Bromo-5-methylpyridine-2-carbonitrile

  • 3,5-dichloropicolinonitrile
  • 2-PYRIDINECARBONITRILE, 3,5-DICHLORO-
  • 2-CYANO-3,5-DICHLOROPYRIDINE
  • 3,5-DICHLORO-2-CYANOPYRIDINE
  • 3,5-Dichloropicolinitrile
  • 3,5-Dichloropyridine-2-carbonitrile
  • Cyanodichloropyridine 235---
  • 3,5-Dichloro-2-pyridinecarbonitrile
  • 3,5-Dichloro-pyridin-2-carbonitrile
  • 2-Cyano-3,5-dichloropyridine, 3,5-Dichloropicolinonitrile
  • 3,5-Dichloro-2-cyanopyridine&gt
  • 3,5-Dichloro-2-cyanopyridine ISO 9001：2015 REACH
  • 3,5-dichboro-2-cyanopyridine
  • 3,5-Dichloror-2-cyanopyridine
  • 85331-33-5
  • 85331-28-7
  • 85311-33-5
  • C6H2C12N2
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridine series
  • Pyridines
  • Pyridine
  • Pyridines derivates
  • C6