ChemicalBook > CAS DataBase List > PF-01367338

PF-01367338

Product Name
PF-01367338
CAS No.
459868-92-9
Chemical Name
PF-01367338
Synonyms
CS-47;Rubraca;AG14699;AG-014699;PF-01367338;Rucaparib(AG-01);Rucaparib D4 HCl;AG014699 phosphate;AG 014699 phosphate;AG-014699 phosphate
CBNumber
CB82515928
Molecular Formula
C19H21FN3O5P
Formula Weight
421.37
MOL File
459868-92-9.mol
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PF-01367338 Property

Melting point:
>173°C (dec.)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
Yellow solid.
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11570
Product name
Rucaparib (phosphate)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11570
Product name
Rucaparib (phosphate)
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
11570
Product name
Rucaparib (phosphate)
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
TRC
Product number
A425500
Product name
AG14699
Packaging
5mg
Price
$90
Updated
2021/12/16
TRC
Product number
A425500
Product name
AG14699
Packaging
10mg
Price
$140
Updated
2021/12/16
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PF-01367338 Chemical Properties,Usage,Production

Description

Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1?Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2?Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3?Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4?Ameliorates the cardiotoxicity of doxorubicin.5?Recently approved for human use by the FDA.

Uses

PARP inhibitor oncolytic

References

1) Thomas?et al.?(2007),?Preclinical selection of a n novel poly(ADP-ribose) polymerase inhibitor for clinical trial; Mol. Cancer Ther.,?6?945 2) Drew?et al.?(2011),?Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2; J. Natl. Cancer Inst.,?103?334 3) Ihnen?et al.?(2013),?Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer; Mol. Cancer Ther.,?12?1002 4) Plummer?et al.?(2013),?A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation; Cancer Chemother. Pharmacol.,?71?1191 5) Ali?et al.?(2011),?The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice; Mol. Cancer Ther.,?10?2320

PF-01367338 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-01367338 Suppliers

Canada 1 China 181 India 4 The Netherlands 1 United States 20 Global 207
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View Lastest Price from PF-01367338 manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
PF-01367338 459868-92-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-10
Hebei Guanlang Biotechnology Co., Ltd.
Product
Rucaparib 459868-92-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2023-04-06
Henan Aochuang Chemical Co.,Ltd.
Product
Rucaparib phosphate;PF01367338 phosphate 459868-92-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

459868-92-9, PF-01367338Related Search:

Olaparib Rucaparib Camsylate 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one 4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde Everolimus MK-2206 2HCl Talazoparib (BMN 673) Veliparib Rapamycin ABT-888 Ruxolitinib Rucaparib

  • PF01367338 phosphate
  • Rucaparib (AG-014699,PF-01367338) phosphate
  • Rucaparib (AG-014699) phosphate
  • AG014699;RUCAPARIB PHOSPHATE
  • Rucaparib (phosphate)(AG-014699,PF-01367338)
  • Rucaparib phosphate salt
  • Rucaparib phosphate (AG-14699, PF-01367338)
  • CS-47
  • AG 014699 - PF 01367338 | Rucaparib
  • AG-014447 (as free base)
  • AG-14699 (as phosphate salt)
  • AG-14699 (AS PHOSPHATE SALT); AG-014447 (AS FREE BASE); RUCAPARIB; PF-01367338; AG014699;
  • AG 014699 phosphate
  • AG014699 phosphate
  • AG-014699 phosphate
  • RUCAPARIB PHOSPHATE;AG014699 PHOSPHATE;PF01367338 PHOSPHATE;AG 014699 PHOSPHATE;PF 01367338 PHOSPHATE;AG-014699 PHOSPHATE;PF-01367338 PHOSPHATE
  • AG14699 (AS PHOSPHATE SALT); AG 14699; AG-14699; AG014447 (AS FREE BASE); AG-014447; AG 014447; PF01367338; PF-01367338; PF 01367338; RUCAPARIB; RUBRACA;
  • Rubraca
  • AG-014699
  • AG-014699;PF-01367338
  • PF-01367338
  • AG14699
  • 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate
  • Rucaparib (AG-014699 , PF-01367338)
  • Rucaparib phosphate
  • AG-014699 (Rucaparib)
  • 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(MethylaMino)Methyl]phenyl]-, phosphate (1:1)
  • PF-01367338/AG14699
  • Rucaparib(AG-014699)
  • 8-fluoro-5-(4-((methylamino)methyl)phenyl)-3,4-dihydro-2H-azepino[5,4,3-cd]indol-1(6H)-one phosphoric acid
  • 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate Rucaparib(AG-014699)
  • AG 014699 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate
  • Rucaparib ( PF-01367338)
  • Rucaparib phosphate AG-014699
  • 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate
  • Rucaparib(AG-01)
  • 8-fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-onephosphate
  • 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one pho
  • PF-01367338 USP/EP/BP
  • Rucaparib D4 HCl
  • TIANFUCHEM--PF-01367338
  • 459868-92-9
  • C19H21FN3O5P
  • C19H18FN3OH3PO4
  • C19H18FN3OH3O4P
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  • Inhibitor
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  • Aromatics
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