ChemicalBook > CAS DataBase List > MK-8998

MK-8998

Product Name: MK-8998
CAS No.: 953778-58-0
Chemical Name: MK-8998
Synonyms: MK-8998;CX-8998;CS-2435;Suvecaltamide;MK8998;MK 8998;MK-8998（compound 33）;Suvecaltamide (MK-8998);Suvecaltamide, 10 mM in DMSO;(R)-2-(4-isopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetaMide;inhibit,MK 8998,Calcium Channel,Ca channels,Inhibitor,Suvecaltamide,Ca2+ channels,MK8998
CBNumber: CB82516066
Molecular Formula: C20H23F3N2O2
Formula Weight: 380.4
MOL File: 953778-58-0.mol

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MK-8998 Property

Boiling point:: 510.3±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (262.88 mM);Water : < 0.1 mg/mL (insoluble)
pka: 14.27±0.46(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C20H23F3N2O2/c1-13(2)16-6-4-15(5-7-16)10-19(26)25-14(3)18-9-8-17(11-24-18)27-12-20(21,22)23/h4-9,11,13-14H,10,12H2,1-3H3,(H,25,26)/t14-/m1/s1
InChIKey: IQIKXZMPPBEWAD-CQSZACIVSA-N
SMILES: C1(CC(N[C@@H](C2=NC=C(OCC(F)(F)F)C=C2)C)=O)=CC=C(C(C)C)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6198
Product name: MK-8998
Purity: 99.94%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-6198
Product name: MK-8998
Purity: 99.94%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-6198
Product name: MK-8998
Purity: 99.94%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0027468
Product name: MK-8998
Purity: 95.00%
Packaging: 5MG
Price: $496
Updated: 2021/12/16

ChemScene

Product number: CS-6198
Product name: MK-8998
Purity: 99.94%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

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MK-8998 Chemical Properties,Usage,Production

Uses

Suvecaltamide (MK-8998) is a selective T-type calcium channel inhibitor with oral efficacy. Suvecaltamide exhibits no cytotoxicity in myeloma cell lines and does not affect the antitumor efficacy of Bortezomib (BTZ). Suvecaltamide reverses BTZ-induced peripheral neuropathy (CIPN) in mouse and rat models, and helps inhibit myeloma growth[1].

in vivo

Suvecaltamide (3-30 mg/kg, once daily for 28 days, orally) reverses the peripheral nerve toxicity (CIPN) induced by Bortezomib (BTZ, HY-10227) in a rat model^[1].
Suvecaltamide (30 mg/kg, once daily for 28 days, orally) reduces tumor volume in a xenograft mouse model of human multiple myeloma without affecting the anti-cancer activity of BTZ^[1].

Animal Model:	BTZ-Induced CIPN Rat Model^[1]
Dosage:	3, 10, 30 mg/kg; once daily for 28 days
Administration:	orally
Result:	Increased raised the nerve conduction velocity (NCV) levels of the tail nerve and sciatic nerve by dose-dependent. Reduced the β-tubulin polymerization caused by BTZ and increased the number of cutaneous unmyelinated fiber in the hindpaw (IENF) at 30 mg/kg, without affecting proteasome activity.

Animal Model:	a START cell-based xenograft athymic nude mouse tumor model of human myeloma^[1]
Dosage:	30 mg/kg, once daily for 28 days
Administration:	orally
Result:	Reduced the size of the tumor without affecting the anti-cancer activity of BTZ or the weight loss effects.

IC 50

T-type calcium channel

References

[1] Cristina Meregalli, et al. Reversal of Bortezomib-Induced Neurotoxicity by Suvecaltamide, a Selective T-Type Ca-Channel Modulator, in Preclinical Models. Cancers (Basel). 2021 Oct 7;13(19):5013. DOI:10.3390/cancers13195013

MK-8998 Preparation Products And Raw materials

Raw materials

Preparation Products

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953778-58-0, MK-8998Related Search:

MK-2206 2HCl MK-5172 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102) MK-4101 MK8745 mk-1064 MK 0557 MK-0812 (Succinate) MKC9989 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK-1775 SCH900776 MK-0752 MKC3946 MK-3903

MK-8998

(R)-2-(4-isopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetaMide

MK8998;MK 8998

CS-2435

CX-8998

Benzeneacetamide, 4-(1-methylethyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-

Suvecaltamide

inhibit,MK 8998,Calcium Channel,Ca channels,Inhibitor,Suvecaltamide,Ca2+ channels,MK8998

Suvecaltamide (MK-8998)

2-[4-(propan-2-yl)phenyl]-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide

Suvecaltamide, 10 mM in DMSO

MK-8998（compound 33）

953778-58-0

API