ChemicalBook > CAS DataBase List > CCT128930

CCT128930

Product Name
CCT128930
CAS No.
885499-61-6
Chemical Name
CCT128930
Synonyms
CS-447;CCT128930;CCT128930, >=98%;CCT128930 (CCT 128930;4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine;4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylamine;4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine;4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-
CBNumber
CB82554024
Molecular Formula
C18H20ClN5
Formula Weight
341.84
MOL File
885499-61-6.mol
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CCT128930 Property

Density 
1.39
storage temp. 
Store at -20°C
solubility 
DMSO : 36.67 mg/mL (107.27 mM; Need ultrasonic)
form 
Powder
pka
13.93±0.50(Predicted)
color 
Off-white to yellow
InChI
InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23)
InChIKey
RZIDZIGAXXNODG-UHFFFAOYSA-N
SMILES
N1(C2N=CN=C3NC=CC3=2)CCC(CC2=CC=C(Cl)C=C2)(N)CC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18194
Product name
CCT128930
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18194
Product name
CCT128930
Purity
≥95%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
18194
Product name
CCT128930
Purity
≥95%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
18194
Product name
CCT128930
Purity
≥95%
Packaging
50mg
Price
$1027
Updated
2024/03/01
TRC
Product number
C227955
Product name
CCT128930
Packaging
5mg
Price
$270
Updated
2021/12/16
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CCT128930 Chemical Properties,Usage,Production

Uses

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM.

Uses

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2.

in vivo

CCT128930 (25 or 40 mg/kg; i.p. daily or twice daily for 5 days) shows antitumor activities in U87MG and BT474 human breast cancer xenografts[1].
Summary of the pharmacokinetic parameters of CCT128930 (25 mg/kg) in CrTacNCr-Fox1nu mice[1]

TissueRouteT1/2
(h)		Tmax
(h)		Cmax
(μM)		Vss
(L)		Cl
(L/h)		AUC0-∞
(μMh)		 Bioavailability
(%)
Plasmai.v.0.950.083 6.36 0.25 0.325 4.62100
Plasmai.p.2.330.51.28N/A0.372 1.3328.8
Tumori.p.3.8918.02N/A0.06*25.8N/A
Plasmap.o.0.570.50.432N/A0.3170.3928.5

*Apparent clearance.
Animal Model:6-8 weeks old female CrTacNCr-Fox1nu mice[1]
Dosage:25 mg/kg (U87MG human glioblastoma xenografts) or 40 mg/kg (BT474 human breast cancer xenografts)
Administration:i.p. daily for 5 days (U87MG human glioblastoma xenografts); i.p. twice daily for 5 days (BT474 human breast cancer xenografts)
Result:Giving a treated:control (T/C) ratio on day 12 of 48%. There was no weight loss associated with this regime in U87MG human glioblastoma xenografts.
Had a profound antitumor effect with complete growth arrest and a T/C ratio of 29% on day 22. This regimen was associated with minimal weight loss, with a nadir of only 94.8% of the initial body weight on day 15 of treatment in BT474 human breast cancer xenografts.

target

Akt2

IC 50

Akt2: 6 nM (IC50); p70S6K: 120 nM (IC50); PKA: 168 nM (IC50); Autophagy; Apoptosis

CCT128930 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT128930 Suppliers

China 93 United Kingdom 1 United States 14 Global 108
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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+1 (866) 930-6790
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+1 (866) 333-9607
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Target molecule Corp.
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857-239-0968
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857-239-8801
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service1@targetmol.com
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Musechem
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+1-800-259-7612
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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United States
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Aladdin Scientific
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Abcam Limited
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Cayman Chemical Company
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Creative Enzymes
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885499-61-6, CCT128930Related Search:

CC-122 CCT 137690 CCG215022 CC-92480 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCT245737 CCF-642 (S)-(+)-Benzyl glycidyl ether 2-Methylpropanedioic acid Benzyl alcohol Poly(methyl methacrylate) 4'-Hydroxyacetophenone Everolimus 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol MK-2206 2HCl A-674563 PF-04691502

  • 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine
  • CCT128930 (CCT 128930
  • CS-447
  • 4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine
  • 4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-
  • CCT128930, >=98%
  • CCT128930
  • 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylamine
  • 885499-61-6
  • C18H20ClN5
  • Akt
  • mTOR
  • PI3K
  • Inhibitors