ChemicalBook > CAS DataBase List > TRICHOSTATIN A

TRICHOSTATIN A

Product Name
TRICHOSTATIN A
CAS No.
58880-19-6
Chemical Name
TRICHOSTATIN A
Synonyms
TSA;A 300I;CS-210;CS-2704;richostatinA;trichostatin;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)
CBNumber
CB8257301
Molecular Formula
C17H22N2O3
Formula Weight
302.37
MOL File
58880-19-6.mol
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TRICHOSTATIN A Property

Melting point:
140-143℃
alpha 
D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density 
1.139
refractive index 
136 ° (C=0.3, MeOH)
storage temp. 
-20°C
solubility 
ethanol: 1 mg/mL
form 
Off-white lyophilized solid
pka
8.93±0.23(Predicted)
color 
Tan
Merck 
14,9649
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
ZWGICMNKJBUOHG-RCXLNATQSA-N
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-43
Safety Statements 
26-36
RIDADR 
NA 1993 / PGIII
WGK Germany 
3
RTECS 
MI5215000
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T1952
Product name
Trichostatin A, Ready Made Solution
Purity
5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
Packaging
200μL
Price
$87.6
Updated
2024/03/01
Sigma-Aldrich
Product number
647925
Product name
Trichostatin A
Packaging
1mg
Price
$289
Updated
2024/03/01
TCI Chemical
Product number
T2477
Product name
Trichostatin A
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$551
Updated
2024/03/01
TCI Chemical
Product number
T2477
Product name
Trichostatin A
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$1901
Updated
2024/03/01
Cayman Chemical
Product number
89730
Product name
Trichostatin A
Purity
≥98%
Packaging
500μg
Price
$56
Updated
2024/03/01
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TRICHOSTATIN A Chemical Properties,Usage,Production

Description

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

Chemical Properties

Solid

Uses

Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity

Uses

Trichostatin A, ready-made solution has been used:

  • as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
  • to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
  • to treat cells for the HDAC inhibition experiments

Uses

Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.

Definition

ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.

General Description

Trichostatin A is a compound of primary hydroxamic acid.

Biological Activity

Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

Biochem/physiol Actions

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

storage

-20°C (desiccate)

References

1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

TRICHOSTATIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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TRICHOSTATIN A Suppliers

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View Lastest Price from TRICHOSTATIN A manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
Trichostatin A 58880-19-6
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-01-17
Shaanxi Dideu Medichem Co. Ltd
Product
Trichostatin A 58880-19-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-07
Dideu Industries Group Limited
Product
TRICHOSTATIN A 58880-19-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-23

58880-19-6, TRICHOSTATIN ARelated Search:

Tubacin HC TOXIN M344 Parthenolide Panobinostat JNJ-26481585 Vorinostat MG-132 Entinostat LY 294002 HYDROCHLORIDE TRICHOSTATIN A SORBOHYDROXAMIC ACID INHIBITOR-1 OF TRICHOSTATIN A,INHIBITOR OF TRICHOSTATIN A 1 TRICHOSTATIN C TRICHOSTATIN B TRICHOSTATIN A (DRY ICE) TRICHOSTATIN, TRICHOSPDRIELLA SP. trichostatin D

  • 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide
  • 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE
  • 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID
  • 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID
  • Trichostatin A from Streptomyces platensis
  • [r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • 7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE
  • TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • TSA
  • TRICHOSTATIN A
  • TRICHOSTATIN A, STREPTOMYCES SPECIES
  • Trichostatin A, Streptomyces sp.
  • 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
  • TRICHOSTATIN A FROM STREPTOMYCES SP
  • (2E,4E,6R)-4,6-Dimethyl-7-[4-(dimethylamino)phenyl]-7-oxo-2,4-heptadienehydroximic acid
  • (2E,4E,6R)-4,6-Dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienehydroximic acid
  • Trichostatin A,TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • (R)-Trichostatin A
  • Trichostatin A (TSA)
  • A 300I
  • (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide
  • Trichostatin A, Ready Made Solution
  • Trichostatin A Vetec(TM) reagent grade, from Streptomyces sp., >=98%
  • (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE
  • Trichostatin A, 98%, from Streptomyces sp.
  • CS-2704
  • CS-210
  • isolated from species of the bacterial genus Streptomyces.
  • richostatinA
  • TRICHOSTATIN A USP/EP/BP
  • trichostatin
  • (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
  • Histone deacetylases,inhibit,Inhibitor,HDAC,Trichostatin A
  • Trichostatin A solution(10mM/L)
  • (+)-Trichostatin A
  • Trichostatin A (R-isomer)
  • 58880-19-6
  • 5880-19-6
  • Gene Regulation and Expression
  • DNA-RNA Transcription Regulators
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Inhibitors
  • antibiotic
  • API
  • Anti Cancer Research
  • Inhibitor