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TRICHOSTATIN A

Product Name
TRICHOSTATIN A
CAS No.
58880-19-6
Chemical Name
TRICHOSTATIN A
Synonyms
TSA;A 300I;CS-210;CS-2704;richostatinA;trichostatin;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)
CBNumber
CB8257301
Molecular Formula
C17H22N2O3
Formula Weight
302.37
MOL File
58880-19-6.mol
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TRICHOSTATIN A Property

Melting point:
140-143℃
alpha 
D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density 
1.139
refractive index 
136 ° (C=0.3, MeOH)
storage temp. 
-20°C
solubility 
ethanol: 1 mg/mL
form 
Off-white lyophilized solid
pka
8.93±0.23(Predicted)
color 
Tan
Merck 
14,9649
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
ZWGICMNKJBUOHG-RCXLNATQSA-N
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-43
Safety Statements 
26-36
RIDADR 
NA 1993 / PGIII
WGK Germany 
3
RTECS 
MI5215000
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T1952
Product name
Trichostatin A, Ready Made Solution
Purity
5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
Packaging
200μL
Price
$87.6
Updated
2024/03/01
Sigma-Aldrich
Product number
647925
Product name
Trichostatin A
Packaging
1mg
Price
$289
Updated
2024/03/01
TCI Chemical
Product number
T2477
Product name
Trichostatin A
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$551
Updated
2024/03/01
TCI Chemical
Product number
T2477
Product name
Trichostatin A
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$1901
Updated
2024/03/01
Cayman Chemical
Product number
89730
Product name
Trichostatin A
Purity
≥98%
Packaging
500μg
Price
$56
Updated
2024/03/01
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TRICHOSTATIN A Chemical Properties,Usage,Production

Description

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

Chemical Properties

Solid

Uses

Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity

Uses

Trichostatin A, ready-made solution has been used:

  • as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
  • to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
  • to treat cells for the HDAC inhibition experiments

Uses

Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.

Definition

ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.

General Description

Trichostatin A is a compound of primary hydroxamic acid.

Biological Activity

Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

Biochem/physiol Actions

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

storage

-20°C (desiccate)

References

1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

TRICHOSTATIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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TRICHOSTATIN A Suppliers

Shanghai jerryxing Biomedical Technology Co., Ltd
Tel
17721492509
Email
643638326@qq.com
Country
China
ProdList
5345
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
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View Lastest Price from TRICHOSTATIN A manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
Trichostatin A 58880-19-6
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-01-17
Hebei shuoxi biotechnology co. LTD
Product
trichostatin A 58880-19-6
Price
US $0.00/KG
Min. Order
1g
Purity
99.9%
Supply Ability
1 ton
Release date
2019-10-23
Longyan Tianhua Biological Technology Co., Ltd
Product
TRICHOSTATIN A 58880-19-6
Price
US $11.00/Kg/Bag
Min. Order
25Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-11-02

58880-19-6, TRICHOSTATIN ARelated Search:


  • 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide
  • 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE
  • 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID
  • 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID
  • Trichostatin A from Streptomyces platensis
  • [r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • 7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE
  • TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • TSA
  • TRICHOSTATIN A
  • TRICHOSTATIN A, STREPTOMYCES SPECIES
  • Trichostatin A, Streptomyces sp.
  • 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
  • TRICHOSTATIN A FROM STREPTOMYCES SP
  • (2E,4E,6R)-4,6-Dimethyl-7-[4-(dimethylamino)phenyl]-7-oxo-2,4-heptadienehydroximic acid
  • (2E,4E,6R)-4,6-Dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienehydroximic acid
  • Trichostatin A,TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • (R)-Trichostatin A
  • Trichostatin A (TSA)
  • A 300I
  • (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide
  • Trichostatin A, Ready Made Solution
  • Trichostatin A Vetec(TM) reagent grade, from Streptomyces sp., >=98%
  • (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE
  • Trichostatin A, 98%, from Streptomyces sp.
  • CS-2704
  • CS-210
  • isolated from species of the bacterial genus Streptomyces.
  • richostatinA
  • TRICHOSTATIN A USP/EP/BP
  • trichostatin
  • (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
  • Histone deacetylases,inhibit,Inhibitor,HDAC,Trichostatin A
  • Trichostatin A solution(10mM/L)
  • (+)-Trichostatin A
  • Trichostatin A (R-isomer)
  • 58880-19-6
  • 5880-19-6
  • Gene Regulation and Expression
  • DNA-RNA Transcription Regulators
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Inhibitors
  • antibiotic
  • API
  • Anti Cancer Research
  • Inhibitor