Isonicotinamide
- Product Name
- Isonicotinamide
- CAS No.
- 1453-82-3
- Chemical Name
- Isonicotinamide
- Synonyms
- PYRIDINE-4-CARBOXAMIDE;IsoniacinaMide;NSC 82353;Isonicotimide;AURORA KA-3066;Isonicotinamid;ISONICOTINAMIDE;4-AMidopyridine;Isonicoitnamide;Isonicotinamide99%
- CBNumber
- CB8259608
- Molecular Formula
- C6H6N2O
- Formula Weight
- 122.12
- MOL File
- 1453-82-3.mol
Isonicotinamide Property
- Melting point:
- 155-157 °C(lit.)
- Boiling point:
- 227.52°C (rough estimate)
- Density
- 1.2236 (rough estimate)
- refractive index
- 1.5350 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pK1: 3.61(+1) (20°C)
- color
- White to Off-White
- Water Solubility
- 191.7 g/L (37 ºC)
- BRN
- 2173
- LogP
- -0.28
- CAS DataBase Reference
- 1453-82-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Pyridinecarboxamide(1453-82-3)
- EPA Substance Registry System
- Isonicotinamide (1453-82-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- I17451
- Product name
- Isonicotinamide
- Purity
- ReagentPlus , 99%
- Packaging
- 25g
- Price
- $45.8
- Updated
- 2024/03/01
- Product number
- I17451
- Product name
- Isonicotinamide
- Purity
- ReagentPlus , 99%
- Packaging
- 100g
- Price
- $78.6
- Updated
- 2024/03/01
- Product number
- 8.14032
- Product name
- 4-Pyridinecarboxylic acid amide
- Purity
- for synthesis
- Packaging
- 50g
- Price
- $71.3
- Updated
- 2022/05/15
- Product number
- I0135
- Product name
- Isonicotinamide
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- I0135
- Product name
- Isonicotinamide
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 500g
- Price
- $178
- Updated
- 2024/03/01
Isonicotinamide Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.
Application
Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.
Preparation
synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.
Definition
ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.
Purification Methods
Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]
Isonicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
Isonicotinamide Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3576
- Advantage
- 66
- Tel
- --
- Fax
- --
- ccc@merckgroup.com
- Country
- Germany
- ProdList
- 2010
- Advantage
- 58
View Lastest Price from Isonicotinamide manufacturers
- Product
- Isonicotinamide 1453-82-3
- Price
- US $115.00-100.00/kilograms
- Min. Order
- 100kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-02-15
- Product
- Isonicotinamide 1453-82-3
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-04-29
- Product
- Isonicotinamide 1453-82-3
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 2000KG/MONTH
- Release date
- 2024-04-17