Isonicotinamide

Product Name: Isonicotinamide
CAS No.: 1453-82-3
Chemical Name: Isonicotinamide
Synonyms: PYRIDINE-4-CARBOXAMIDE;IsoniacinaMide;NSC 82353;Isonicotimide;AURORA KA-3066;Isonicotinamid;ISONICOTINAMIDE;4-AMidopyridine;Isonicoitnamide;Isonicotinamide99%
CBNumber: CB8259608
Molecular Formula: C6H6N2O
Formula Weight: 122.12
MOL File: 1453-82-3.mol

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Isonicotinamide Property

Melting point:: 155-157 °C(lit.)
Boiling point:: 227.52°C (rough estimate)
Density: 1.2236 (rough estimate)
refractive index: 1.5350 (estimate)
storage temp.: Store below +30°C.
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: pK1: 3.61(+1) (20°C)
color: White to Off-White
Water Solubility: 191.7 g/L (37 ºC)
BRN: 2173
LogP: -0.28
CAS DataBase Reference: 1453-82-3(CAS DataBase Reference)
NIST Chemistry Reference: 4-Pyridinecarboxamide(1453-82-3)
EPA Substance Registry System: Isonicotinamide (1453-82-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: NR9500000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I17451
Product name: Isonicotinamide
Purity: ReagentPlus , 99%
Packaging: 25g
Price: $45.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: I17451
Product name: Isonicotinamide
Purity: ReagentPlus , 99%
Packaging: 100g
Price: $78.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14032
Product name: 4-Pyridinecarboxylic acid amide
Purity: for synthesis
Packaging: 50g
Price: $71.3
Updated: 2022/05/15

TCI Chemical

Product number: I0135
Product name: Isonicotinamide
Purity: >99.0%(HPLC)(T)
Packaging: 25g
Price: $29
Updated: 2024/03/01

TCI Chemical

Product number: I0135
Product name: Isonicotinamide
Purity: >99.0%(HPLC)(T)
Packaging: 500g
Price: $178
Updated: 2024/03/01

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Isonicotinamide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.

Application

Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.

Preparation

synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.

Definition

ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.

Purification Methods

Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]

Isonicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

Forchlorfenuron

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View Lastest Price from Isonicotinamide manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: Isonicotinamide 1453-82-3
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-08

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Isonicotinamide 1453-82-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-17

Hebei Longbang Technology Co., Ltd

Product: Isonicotinamide 1453-82-3
Price: US $6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-04-29

1453-82-3, IsonicotinamideRelated Search:

N,N-Dimethylformamide Isonicotinic acid Formamide Chlorantraniliprole Formamide,Deionized Isoniazid ISONICOTINOYL CHLORIDE HYDROCHLORIDE Benzamide PYRIDINE-2-CARBOXAMIDE Nicotinamide SODIUM 4-PYRIDINECARBOXYLATE TETRAHYDRATE Methyl isonicotinate N-phenyl isonicotinamide PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 3,5-bis(pyridin-4-yl)-4-amino-1,2,4-triazole 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE tert-Butyl isonicotinate ETHYL ISONICOTINOYLACETATE

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gamma-Pyridinecarboxamide

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Isonicotinamide Vetec(TM) reagent grade, 98%

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PYRIDINE-4-CARBOXAMIDE

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Isonicotinamide99%

pridine-4-Carboxamide

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4-(AMinocarbonyl)pyridine

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IsoniacinaMide

NSC 82353

4-PYRIDINECARBOXYLIC ACID AMIDE FOR SYNT

Different nicotinaMide

Pyridine-4-carboxamide, 4-Carbamoylpyridine

2-carbaMoylpyridine-4-carboxylic acid

IsonicotinaMide, 99% 25GR

IsonicotinaMide ReagentPlus(R), 99%

Nicotinamide EP Impurity D

Isonicotinamide reference substance

Isonicotinamide&gt

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Isonicotinamide ISO 9001：2015 REACH

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pyridine-4-carboxamide (isonicotinamide)

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1453-82-3

Heterocyclic Building Blocks

Pyridines

Building Blocks

C6

Apoptosis, Aromatics, Heteocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Pyridine