ChemicalBook > CAS DataBase List > Isonicotinamide

Isonicotinamide

Product Name
Isonicotinamide
CAS No.
1453-82-3
Chemical Name
Isonicotinamide
Synonyms
PYRIDINE-4-CARBOXAMIDE;IsoniacinaMide;NSC 82353;Isonicotimide;AURORA KA-3066;Isonicotinamid;ISONICOTINAMIDE;4-AMidopyridine;Isonicoitnamide;Isonicotinamide99%
CBNumber
CB8259608
Molecular Formula
C6H6N2O
Formula Weight
122.12
MOL File
1453-82-3.mol
More
Less

Isonicotinamide Property

Melting point:
155-157 °C(lit.)
Boiling point:
227.52°C (rough estimate)
Density 
1.2236 (rough estimate)
refractive index 
1.5350 (estimate)
storage temp. 
Store below +30°C.
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
pK1: 3.61(+1) (20°C)
color 
White to Off-White
Water Solubility 
191.7 g/L (37 ºC)
BRN 
2173
LogP
-0.28
CAS DataBase Reference
1453-82-3(CAS DataBase Reference)
NIST Chemistry Reference
4-Pyridinecarboxamide(1453-82-3)
EPA Substance Registry System
Isonicotinamide (1453-82-3)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
NR9500000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29333999
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I17451
Product name
Isonicotinamide
Purity
ReagentPlus , 99%
Packaging
25g
Price
$45.8
Updated
2024/03/01
Sigma-Aldrich
Product number
I17451
Product name
Isonicotinamide
Purity
ReagentPlus , 99%
Packaging
100g
Price
$78.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14032
Product name
4-Pyridinecarboxylic acid amide
Purity
for synthesis
Packaging
50g
Price
$71.3
Updated
2022/05/15
TCI Chemical
Product number
I0135
Product name
Isonicotinamide
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
I0135
Product name
Isonicotinamide
Purity
>99.0%(HPLC)(T)
Packaging
500g
Price
$178
Updated
2024/03/01
More
Less

Isonicotinamide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.

Application

Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.

Preparation

synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.

Definition

ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.

Purification Methods

Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]

Isonicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

Forchlorfenuron
More
Less

Isonicotinamide Suppliers

Americas 1 Austria 1 Belgium 3 Canada 3 China 327 Europe 3 France 1 Germany 8 India 31 Japan 11 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 13 United States 43 Venezuela 1 Global 452
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
852
Advantage
58
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
193
Advantage
58
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
Taizhou Chemedir Biopharm-tech. Co., Ltd
Tel
0523-86200218 18994667082
Fax
+86 523-86200613
Email
sale1_cmd@chemedir.com
Country
China
ProdList
110
Advantage
64
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4388
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Shanghai Shenyue Chemical Co., Ltd.
Tel
021-021-52212593 15300879511
Fax
+86 (21) 51062076
Email
sales@nuohey.com
Country
China
ProdList
5115
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9452
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9352
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
Simagchem Corp.
Tel
86 592 2680277
Fax
0086 592 2680237
Email
sale@simagchem.com
Country
China
ProdList
430
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7876
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7854
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2549
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2671
Advantage
55
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9352
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3033
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13359
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2661
Advantage
58
More
Less

View Lastest Price from Isonicotinamide manufacturers

Hebei Dangtong Import and export Co LTD
Product
Isonicotinamide 1453-82-3
Price
US $115.00-100.00/kilograms
Min. Order
100kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-15
Hebei Longbang Technology Co., Ltd
Product
Isonicotinamide 1453-82-3
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-04-29
Hebei Saisier Technology Co., LTD
Product
Isonicotinamide 1453-82-3
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/MONTH
Release date
2024-04-17

1453-82-3, IsonicotinamideRelated Search:

N,N-Dimethylformamide Isonicotinic acid Formamide Chlorantraniliprole Formamide,Deionized Isoniazid ISONICOTINOYL CHLORIDE HYDROCHLORIDE Benzamide PYRIDINE-2-CARBOXAMIDE Nicotinamide SODIUM 4-PYRIDINECARBOXYLATE TETRAHYDRATE Methyl isonicotinate N-phenyl isonicotinamide PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE 3,5-bis(pyridin-4-yl)-4-amino-1,2,4-triazole 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE tert-Butyl isonicotinate ETHYL ISONICOTINOYLACETATE

  • 4-Carbamoylpyridine
  • gamma-Pyridinecarboxamide
  • IsonicotinaMide, 99.0%(T)
  • Isonicotinamide Vetec(TM) reagent grade, 98%
  • Isonicotimide
  • 4-Pyridinecarboxylic acid amide for synthesis
  • Isoniazid Impurity 3
  • Nicotinamide Impurity 4(Nicotinamide EP Impurity D)
  • PYRIDINE-4-CARBOXAMIDE
  • PYRIDINE-4-CARBOXYLIC ACID AMIDE
  • AURORA KA-3066
  • ISONICOTINIC ACID AMIDE
  • ISONICOTINAMIDE
  • 4-PYRIDINECARBOXYLIC ACID AMIDE
  • 4-PYRIDINE CARBOXAMIDE
  • Isonicotinamide99%
  • pridine-4-Carboxamide
  • Isonicotinamid
  • Pyridine-4-carbamide
  • 4-(AMinocarbonyl)pyridine
  • 4-AMidopyridine
  • IsoniacinaMide
  • NSC 82353
  • 4-PYRIDINECARBOXYLIC ACID AMIDE FOR SYNT
  • Different nicotinaMide
  • Pyridine-4-carboxamide, 4-Carbamoylpyridine
  • 2-carbaMoylpyridine-4-carboxylic acid
  • IsonicotinaMide, 99% 25GR
  • IsonicotinaMide ReagentPlus(R), 99%
  • Nicotinamide EP Impurity D
  • Isonicotinamide reference substance
  • Isonicotinamide&gt
  • Isonicoitnamide
  • 4-pyridine formamide
  • Isonicotinamide ISO 9001：2015 REACH
  • Nicotinamide EP Impurity D (Isonicotinamide)
  • Isoniazid EP Impurity B
  • Isonicotinamide (6CI, 7CI, 8CI)
  • pyridine-4-carboxamide (isonicotinamide)
  • Isopyridin-3-carboxamide
  • Nicotinamide EP Impurity D (Isonicotinamide、Isoniazid EP Impurity B)
  • 1453-82-3
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • C6
  • Apoptosis, Aromatics, Heteocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Pyridine