ChemicalBook > CAS DataBase List > VU 0364770

VU 0364770

Product Name
VU 0364770
CAS No.
61350-00-3
Chemical Name
VU 0364770
Synonyms
SKL856;VU 0364770;VU 0364770 100MG;VU 0364770 USP/EP/BP;VU0364770;VU-0364770;VU0364770, 10 mM in DMSO;N-(3-Chlorophenyl)picolinamide;N-(3-chlorophenyl)pyridine-2-carboxamide;2-PyridinecarboxaMide, N-(3-chlorophenyl)-
CBNumber
CB82596686
Molecular Formula
C12H9ClN2O
Formula Weight
232.67
MOL File
61350-00-3.mol
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VU 0364770 Property

Melting point:
81-83 °C
Boiling point:
293.6±20.0 °C(Predicted)
Density 
1.341±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml
form 
Powder
pka
11.24±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22927
Product name
VU0364770
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
22927
Product name
VU0364770
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
22927
Product name
VU0364770
Packaging
25mg
Price
$298
Updated
2024/03/01
Cayman Chemical
Product number
22927
Product name
VU0364770
Packaging
50mg
Price
$435
Updated
2024/03/01
Tocris
Product number
4469
Product name
VU0364770
Purity
≥99%(HPLC)
Packaging
50
Price
$724
Updated
2021/12/16
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VU 0364770 Chemical Properties,Usage,Production

Uses

N-(3-Chlorophenyl)-2-pyridinecarboxamide shows positive allosteric modulation at the mGlu4 receptors in combination with other antagonists resulting in treatment for the neurodegenerative Parkinson’s disease (1).

in vivo

VU0364770 exhibits suitable pharmacokinetic properties for systemic dosing in animal models. After intravenous administration, VU0364770 is rapidly clears from the systemic circulation (165 ml/min/kg) and exhibits a volume of distribution of 2.92 L/kg. VU0364770 is a highly protein-bound ligand displaying free fractions of 2.7 and 1.8% in human and rat plasma, respectively. VU0364770 also shows an improved pharmacokinetic profile relative to previously reported mGlu4 PAMs with enhanced central penetration and a total brain-to-plasma ratio of more than 1 after systemic administration of a 10 mg/kg dose. VU0364770 produces a dose-dependent reversal of haloperidol-induced catalepsy. VU0364770 dose-dependently reverses haloperidol (0.75 mg/kg)-induced catalepsy in rats, significant at doses of 10 to 56.6 mg/kg, after subcutaneous dosing (F6,69=8.04; p<0.001)[1].

IC 50

Rat mGlu4: 290 nM (EC50); Human mGlu4: 1.1 μM (EC50); mGlu6: 6.8 μM (EC50); mGlu5: 17.9 μM (EC50)

VU 0364770 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0364770 Suppliers

Canada 1 China 101 India 1 United Kingdom 1 United States 12 Global 116
EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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United States
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8447
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Target molecule Corp.
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857-239-0968
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857-239-8801
Email
service1@targetmol.com
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United States
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2559
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60
Musechem
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+1-800-259-7612
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+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
ApexBio Technology
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sales@apexbt.com
Country
United States
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6251
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58
Cayman Chemical Company
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--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
United States Biological
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chemicals@usbio.net
Country
United States
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6214
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MedChemExpress
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United States
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Matrix Scientific
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sales@matrixscientific.com
Country
United States
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6632
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61350-00-3, VU 0364770Related Search:

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide VU0155041 VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439

  • VU 0364770
  • 2-PyridinecarboxaMide, N-(3-chlorophenyl)-
  • N-(3-Chlorophenyl)picolinamide
  • N-(3-chlorophenyl)pyridine-2-carboxamide
  • VU 0364770 100MG
  • VU0364770;VU-0364770
  • VU 0364770 USP/EP/BP
  • SKL856
  • VU0364770, 10 mM in DMSO
  • 61350-00-3
  • Aromatics, Heterocycles
  • Inhibitors