PR-619

Product Name: PR-619
CAS No.: 2645-32-1
Chemical Name: PR-619
Synonyms: PR-619;CS-1128;6-Diamino-3;PR-619;PR619;PR-619, >=98%;PR-619 USP/EP/BP;5-dithiocyanopyridine;2,6-DiaMino-3,5-dithiocyanopyridine;3,5-dithiocyanatopyridine-2,6-diaMine;3,5-Bis-thiocyanato-pyridine-2,6-diamine
CBNumber: CB82656906
Molecular Formula: C7H5N5S2
Formula Weight: 223.28
MOL File: 2645-32-1.mol

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PR-619 Property

Melting point:: 210℃
Boiling point:: 406.0±45.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble5mg/mL (clear solution)
pka: -0.19±0.50(Predicted)
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41-43
Safety Statements: 26-36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0430
Product name: PR-619
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0430
Product name: PR-619
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $316
Updated: 2024/03/01

Cayman Chemical

Product number: 16276
Product name: PR-619
Purity: ≥98%
Packaging: 5mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 16276
Product name: PR-619
Purity: ≥98%
Packaging: 10mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 16276
Product name: PR-619
Purity: ≥98%
Packaging: 25mg
Price: $156
Updated: 2024/03/01

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PR-619 Chemical Properties,Usage,Production

Description

PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become unregulated in cell lysates and will act quickly to deubiquitinate proteins of interest during cell lysis. To preserve maximum amounts of ubiquitinated protein, include PR-619 (50-100 μM) in lysis buffers. PR-619 is also useful for interrogating the role of DUBs in intact cell systems2, and treatment of cells results in an overall accumulation of ubiquitinated proteins and many other phenotypes.

Uses

PR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines an d bisthiazolopyridines.

Uses

PR-619 has been used:

as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Biochem/physiol Actions

PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

storage

Store at -20°C

References

1) Altun?et al. (2011),?Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes; Chem. Biol.,?18?1401 2) Seiberlich?et al. (2012),?The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases; Biochim. Biophys. Acta,?1823?2057

PR-619 Preparation Products And Raw materials

Raw materials

Preparation Products

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PR-619 Suppliers

Canada 1 China 116 India 3 United Kingdom 1 United States 18 Global 139

Target molecule Corp.

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Musechem

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InvivoChem

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View Lastest Price from PR-619 manufacturers

Career Henan Chemical Co

Product: PR-619 2645-32-1
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

2645-32-1, PR-619Related Search:

Ko 143 TYRPHOSTIN AG 1296 S-Trityl-L-cysteine (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Bortezomib Degrasyn (WP1130) PYR 41 MG-132 P-5091 P 22077

PR-619

2,6-DiaMino-3,5-dithiocyanopyridine

3,5-dithiocyanatopyridine-2,6-diaMine

Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester

2,6-Diamino-3,5-dithiocyanopyridine PR 619

PR 619 2,6-Diamino-3,5-dithiocyanopyridine

2,6-Diaminopyridine-3,5-bis(thiocyanate)

PR-619;PR619

3,5-Bis-thiocyanato-pyridine-2,6-diamine

2,6-Diamino-3,5-dithiocyanato-pyridin, 98%

PR-619, >=98%

2;6-DIAMINO-3;5-DITHIOCYANOPYRIDINE;PR 619;PR619

5-dithiocyanopyridine

6-Diamino-3

CS-1128

PR-619 USP/EP/BP

(2,6-diamino-5-thiocyanatopyridin-3-yl)thiocyanate

DUBs,tau,G0/G1,Autophagy,PR-619,PR619,Deubiquitinase,ER-stress,ubiquitination,inhibit,Inhibitor,Apoptosis,arrest

Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester

2645-32-1

Inhibitors