1-BOC-Piperazine

ChemicalBook > CAS DataBase List > 1-BOC-Piperazine

Uses

Product Name: 1-BOC-Piperazine
CAS No.: 57260-71-6
Chemical Name: 1-BOC-Piperazine
Synonyms: 1-BOC-PIPERAZINE;BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene
CBNumber: CB8268275
Molecular Formula: C9H18N2O2
Formula Weight: 186.25
MOL File: 57260-71-6.mol

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1-BOC-Piperazine Property

Melting point:: 43-47 °C(lit.)
Boiling point:: 98-100
Density: 1.030±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in DMSO
pka: 8.45±0.10(Predicted)
form: Low Melting Crystalline Mass
color: White to light yellow
Water Solubility: Soluble in ethyl acetate, methanol and water.
Sensitive: Air Sensitive
BRN: 879985
InChIKey: CWXPZXBSDSIRCS-UHFFFAOYSA-N
CAS DataBase Reference: 57260-71-6(CAS DataBase Reference)
NIST Chemistry Reference: T-butyl 1-piperaziencarboxylate(57260-71-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 3263
WGK Germany: 3
F: 3-10-34
HazardClass: IRRITANT
HS Code: 29335995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15502
Product name: 1-Boc-piperazine
Purity: ≥98.0% (GC)
Packaging: 5g
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: 15502
Product name: 1-Boc-piperazine
Purity: ≥98.0% (GC)
Packaging: 25g
Price: $265
Updated: 2024/03/01

TCI Chemical

Product number: B2415
Product name: 1-(tert-Butoxycarbonyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: B2415
Product name: 1-(tert-Butoxycarbonyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $228
Updated: 2024/03/01

Alfa Aesar

Product number: L13363
Product name: 1-Boc-piperazine, 99%
Packaging: 1g
Price: $29.65
Updated: 2024/03/01

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1-BOC-Piperazine Chemical Properties,Usage,Production

Uses

N-Boc-piperazine is a compound useful in organic synthesis.

Chemical Properties

Waxy Solid

Uses

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

Uses

1-Boc-piperazine may be used in:

preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors

Application

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.

General Description

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K₃PO₄ (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

1-BOC-Piperazine Preparation Products And Raw materials

Raw materials

Ethanol Di-tert-butyl dicarbonate Piperazine Dichloromethane Methanol Sodium hydroxide PETROLEUM ETHER

Preparation Products

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 1-(2-Methoxyethyl)piperazine 1-(CYCLOPROPYLMETHYL)PIPERAZINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 1-Boc-4-(2-formylphenyl)piperazine 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 1-(2-PYRAZINYL)-PIPERAZINE N-Boc-4-(Cyclopropylmethyl)piperazine

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View Lastest Price from 1-BOC-Piperazine manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: tert-Butyl 1-piperazinecarboxylate 57260-71-6
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 3000kg
Release date: 2024-05-14

Hebei Weibang Biotechnology Co., Ltd

Product: tert-Butyl 1-piperazinecarboxylate 57260-71-6
Price: US $19.90/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Hebei Weibang Biotechnology Co., Ltd

Product: tert-Butyl 1-piperazinecarboxylate 57260-71-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

57260-71-6, 1-BOC-Piperazine Related Search:

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1-Boc-piperazine,99%

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1-Piperazinecarboxylic Acid tert-Butyl Este

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BUTTPARK 52\11-35

BOC-PAZ

BOC-PIPERAZINE

1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate

1-BOC-PIPERAZINE, PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-N-BOC-PIPERAZINE 99+%

Piperazine, N1-BOC protected 98%

1-BOC-PIPERAZINE hydrochloride

N-Boc-piperazine [N-(tert-Butoxycarbonyl)-piperazine]

1-Boc-piperazine >=98.0% (GC)

1-Boc-piperazine 97%

N - bok - piperazine

1-Boc-piperazine≥ 99%(GC)

tert-butyl piperazine-1-carbox

tert-Butyl 1-piperazinecarboxyl

1,1-Dimethylethyl 1-piperazinecarboxylate

Tert-Butyl 1-Piperazinecarboxylate1

N-Boc-piperazine hydrochloride

1-Boc-piperazine ,98%

tert-Butyl 1-piperazinecarboxylate,97%

tert-Butyl 1-piperazinecarboxylate，1-N-Boc-Piperazine

1-Boc-piperazine,tert-Butyl piperazine-1-carboxylate

tert-butyl piperazine-1-carboxylate(SALTDATA: FREE)

t-Butyl 1-piperazincarboxylate

TERT-BUTYL N-PIPERAZINE

TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE

TERT-BUTYL 1-PIPERAZINECARBOXYLATE

RARECHEM AR PA 0026

PIBOC

PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

N-BOC-PIPERAZINE

N-(T-BOC)PIPERAZINE

N-T-BUTOXYCARBONYLPIPERAZINE

N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE

N-(TERT-BUTOXYCARBONYL)PIPERAZINE

1-[(1,1-DiMethylethoxy)carbonyl]piperazine

1-Piperazinecarboxylic Acid tert-Butyl Ester

1-N-BOC-PIPERAZINE

1-(TERT-BUTOXYCARBONYL)PIPERAZINE

N-(tert-Butoxycarbonyl)piperazine, tert-Butyl piperazine-1-carboxylate

tert-Butyl 1-piperazinecarboxylate, 97% 5GR

tert-Butyl 1-piperazincarboxylate

1-Boc-piperazine, 98%, for synthesis

1-(tert-Butoxycarbonyl)piperazine &gt

Avatrombopag Impurity 28

BOC-PAZ/1-Boc-piperazine

tert-Butyl 1-piperazinecarboxylate ISO 9001：2015 REACH

tert-butyl piperazine-1-carboylate

Tertbutylpiperzine-1-carboxylate (N-Boc-piperazine)

t-BUTYL PIPERZINE-1-CARBOXYLATE