Uses
ChemicalBook > CAS DataBase List > 1-BOC-Piperazine

1-BOC-Piperazine

Uses
Product Name
1-BOC-Piperazine
CAS No.
57260-71-6
Chemical Name
1-BOC-Piperazine
Synonyms
1-BOC-PIPERAZINE;BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene
CBNumber
CB8268275
Molecular Formula
C9H18N2O2
Formula Weight
186.25
MOL File
57260-71-6.mol
More
Less

1-BOC-Piperazine Property

Melting point:
43-47 °C(lit.)
Boiling point:
98-100
Density 
1.030±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO
pka
8.45±0.10(Predicted)
form 
Low Melting Crystalline Mass
color 
White to light yellow
Water Solubility 
Soluble in ethyl acetate, methanol and water.
Sensitive 
Air Sensitive
BRN 
879985
InChIKey
CWXPZXBSDSIRCS-UHFFFAOYSA-N
CAS DataBase Reference
57260-71-6(CAS DataBase Reference)
NIST Chemistry Reference
T-butyl 1-piperaziencarboxylate(57260-71-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
3263
WGK Germany 
3
F 
3-10-34
HazardClass 
IRRITANT
HS Code 
29335995
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15502
Product name
1-Boc-piperazine
Purity
≥98.0% (GC)
Packaging
5g
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
15502
Product name
1-Boc-piperazine
Purity
≥98.0% (GC)
Packaging
25g
Price
$265
Updated
2024/03/01
TCI Chemical
Product number
B2415
Product name
1-(tert-Butoxycarbonyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$71
Updated
2024/03/01
TCI Chemical
Product number
B2415
Product name
1-(tert-Butoxycarbonyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$228
Updated
2024/03/01
Alfa Aesar
Product number
L13363
Product name
1-Boc-piperazine, 99%
Packaging
1g
Price
$29.65
Updated
2024/03/01
More
Less

1-BOC-Piperazine Chemical Properties,Usage,Production

Uses

N-Boc-piperazine is a compound useful in organic synthesis.

Chemical Properties

Waxy Solid

Uses

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

Uses

1-Boc-piperazine may be used in:

  • preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
  • termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
  • preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors

Application

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.

General Description

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

1-BOC-Piperazine Preparation Products And Raw materials

Raw materials

Ethanol Di-tert-butyl dicarbonate Piperazine Dichloromethane Methanol Sodium hydroxide PETROLEUM ETHER

Preparation Products

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 1-(2-Methoxyethyl)piperazine 1-(CYCLOPROPYLMETHYL)PIPERAZINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 1-Boc-4-(2-formylphenyl)piperazine 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 1-(2-PYRAZINYL)-PIPERAZINE N-Boc-4-(Cyclopropylmethyl)piperazine
More
Less

1-BOC-Piperazine Suppliers

Americas 1 Belgium 3 Canada 3 China 618 Europe 4 France 3 Germany 16 Hungary 1 India 89 Ireland 1 Japan 5 Russia 1 South Korea 1 Sweden 2 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 23 United States 74 Global 851
BTC pharm India
Tel
+918790379245
Email
banny.janga@btcpharm.com
Country
India
ProdList
1262
Advantage
58
GLR Innovations
Tel
+91 9891111994
Email
info@glrgroup.in
Country
India
ProdList
4535
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
ALLCHEM LIFESCIENCE PVT. LTD
Tel
--
Fax
--
Email
info@allchemlifescience.com
Country
India
ProdList
317
Advantage
58
SRISYN LABS
Tel
--
Fax
--
Email
info@srisyn.com
Country
India
ProdList
31
Advantage
58
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
marketing@srlchem.com
Country
India
ProdList
4315
Advantage
58
Triveni chemicals
Tel
--
Fax
--
Email
sales@trivenichemical.com
Country
India
ProdList
6088
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
SPB Pharma Chiemimpex
Tel
--
Fax
--
Email
sales@spbpharmachem.com
Country
India
ProdList
94
Advantage
58
Survival Technologies Pvt., Ltd. (STPL)
Tel
--
Fax
--
Email
info@survivaltechnologies.in
Country
India
ProdList
119
Advantage
58
Chaturya Biotech (Tanuj Life Sciences)
Tel
--
Fax
--
Email
info@chaturyabiotech.com
Country
India
ProdList
398
Advantage
58
Innovative Synthetic Molecules
Tel
--
Fax
--
Country
India
ProdList
526
Advantage
58
Vignasai Laboratories Pvt., Ltd.
Tel
--
Fax
--
Email
info@vignasailabs.com
Country
India
ProdList
169
Advantage
58
Parth Antibiotics Pvt., Ltd.
Tel
--
Fax
--
Email
info@parthantibiotics.com
Country
India
ProdList
137
Advantage
58
Chemrich Fine Chemicals Pvt., Ltd.
Tel
--
Fax
--
Email
info@chemrichfine.com
Country
India
ProdList
399
Advantage
58
Nchem Laboratories
Tel
--
Fax
--
Country
India
ProdList
156
Advantage
58
Enzal Chemicals (India) Ltd.
Tel
--
Fax
--
Country
India
ProdList
13
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
Aruvi Labs
Tel
--
Fax
--
Email
info@aruvilabs.com
Country
India
ProdList
68
Advantage
58
Amino Organics
Tel
--
Fax
--
Country
India
ProdList
86
Advantage
58
Dhanvi Exim Services
Tel
--
Fax
--
Email
info@dhanviexim.com
Country
India
ProdList
204
Advantage
58
Azole Rasayanas India Private Limited
Tel
--
Fax
--
Email
info@azolerasayanas.com
Country
India
ProdList
681
Advantage
58
Reddy N Reddy Pharmaceuticals
Tel
--
Fax
--
Country
India
ProdList
473
Advantage
58
Rampex Labs Pvt., Ltd.
Tel
--
Fax
--
Email
prasanth@rampexlabs.com
Country
India
ProdList
39
Advantage
58
Brisben Chemicals
Tel
--
Fax
--
Country
India
ProdList
508
Advantage
58
Blue Waters International
Tel
--
Fax
--
Email
dharmesh.gandhi@blue-waters.in
Country
India
ProdList
86
Advantage
58
TSK Lifesciences
Tel
--
Fax
--
Email
tsklifesciences@gmail.com
Country
India
ProdList
246
Advantage
58
Ami Organics Limited.
Tel
--
Fax
--
Email
mail@amiorganics.com
Country
India
ProdList
119
Advantage
58
Innovative Labs
Tel
--
Fax
--
Email
info@innovativelabsindia.com
Country
India
ProdList
110
Advantage
58
ASM Organics
Tel
--
Fax
--
Country
India
ProdList
1185
Advantage
58
Azeocryst Organics Pvt., Ltd.
Tel
--
Fax
--
Email
nandubhirud@azeocryst.com
Country
India
ProdList
12
Advantage
58
Darshan Pharma Chem
Tel
--
Fax
--
Email
darshanpharma3609@yahoo.com
Country
India
ProdList
23
Advantage
58
SLS Pharmaceuticals Private Limited
Tel
--
Fax
--
Country
India
ProdList
60
Advantage
58
Silica Hetero Cyclics
Tel
--
Fax
--
Country
India
ProdList
120
Advantage
58
VASIN BIO LIFE SCIENCES PVT LTD
Tel
--
Fax
--
Email
info@vasinbio.com
Country
India
ProdList
2092
Advantage
58
Meenaakshi Molecules Pvt., Ltd.
Tel
--
Fax
--
Email
Info@meenaakshi.in
Country
India
ProdList
32
Advantage
58
Rivashaa Agrotech Biopharma Pvt. Ltd.
Tel
--
Fax
--
Email
source@rivashaa.com
Country
India
ProdList
986
Advantage
58
HiMedia Laboratories
Tel
--
Fax
--
Email
o@himedialabs.com
Country
India
ProdList
1841
Advantage
58
Cns Chemicals
Tel
--
Fax
--
Country
India
ProdList
262
Advantage
58
Noble Molecular Research
Tel
--
Fax
--
Country
India
ProdList
53
Advantage
58
Anand Agencies
Tel
--
Fax
--
Email
en@gmail.com
Country
India
ProdList
2332
Advantage
58
Sai Sree Chemicals
Tel
--
Fax
--
Email
saisreechemicals205@gmail.com
Country
India
ProdList
89
Advantage
58
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Tel
--
Fax
--
Email
mayur@archerchem.com
Country
India
ProdList
147
Advantage
58
Reax Chemicals
Tel
--
Fax
--
Country
India
ProdList
4217
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
Bharavi Laboratories (P) Ltd.
Tel
--
Fax
--
Email
bharavi@vsnl.com
Country
India
ProdList
121
Advantage
50
Survival Technologies Pvt Ltd
Tel
--
Fax
--
Email
swami@survivaltechnologies.in
Country
India
ProdList
290
Advantage
50
Avra Synthesis Pvt Ltd
Tel
--
Fax
--
Email
info@avrasynthesis.com
Country
India
ProdList
1603
Advantage
30
Globe Chemie
Tel
--
Fax
--
Email
info@globechemie.co.in
Country
India
ProdList
293
Advantage
50
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
More
Less

View Lastest Price from 1-BOC-Piperazine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
tert-Butyl 1-piperazinecarboxylate 57260-71-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-07
hebei hongtan Biotechnology Co., Ltd
Product
tert-Butyl 1-piperazinecarboxylate 57260-71-6
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
3000kg
Release date
2024-05-14
Hebei Weibang Biotechnology Co., Ltd
Product
tert-Butyl 1-piperazinecarboxylate 57260-71-6
Price
US $19.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13

57260-71-6, 1-BOC-Piperazine Related Search:

Cyhalofop-butyl 2-Ethylhexyl ferulate tert-Butanol Dibutyl phthalate Piperacillin BUTYL OLEATE Piperazine Buprofezin N-Carbobenzyloxyglycine N-Aminoethylpiperazine RESMETHRIN BOC-PIPERAZINE HYDROCHLORIDE 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one PIPERAZINE DIHYDROCHLORIDE 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid 1,1,3,3-Tetramethylurea 1-Hydroxybenzotriazole 5-Bromo-2-fluorobenzonitrile

  • 1-Boc-piperazine,99%
  • 1-(tert-Butyloxycarbonyl)piperazine
  • 1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
  • 1-Piperazinecarboxylic Acid tert-Butyl Este
  • N-(tert-Butoxycarbonyl)piperazine 98%
  • Piperazine, N1-BOC protected
  • tert-Butyl 2-piperazinecarboxylate
  • N-(T-BUTYLOXYCARBONYL)-PIPERAZINE
  • BUTTPARK 52\11-35
  • BOC-PAZ
  • BOC-PIPERAZINE
  • 1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate
  • 1-BOC-PIPERAZINE, PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-N-BOC-PIPERAZINE 99+%
  • Piperazine, N1-BOC protected 98%
  • 1-BOC-PIPERAZINE hydrochloride
  • N-Boc-piperazine [N-(tert-Butoxycarbonyl)-piperazine]
  • 1-Boc-piperazine >=98.0% (GC)
  • 1-Boc-piperazine 97%
  • N - bok - piperazine
  • 1-Boc-piperazine≥ 99%(GC)
  • tert-butyl piperazine-1-carbox
  • tert-Butyl 1-piperazinecarboxyl
  • 1,1-Dimethylethyl 1-piperazinecarboxylate
  • Tert-Butyl 1-Piperazinecarboxylate1
  • N-Boc-piperazine hydrochloride
  • 1-Boc-piperazine ,98%
  • tert-Butyl 1-piperazinecarboxylate,97%
  • tert-Butyl 1-piperazinecarboxylate，1-N-Boc-Piperazine
  • 1-Boc-piperazine,tert-Butyl piperazine-1-carboxylate
  • tert-butyl piperazine-1-carboxylate(SALTDATA: FREE)
  • t-Butyl 1-piperazincarboxylate
  • TERT-BUTYL N-PIPERAZINE
  • TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE
  • TERT-BUTYL 1-PIPERAZINECARBOXYLATE
  • RARECHEM AR PA 0026
  • PIBOC
  • PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • N-BOC-PIPERAZINE
  • N-(T-BOC)PIPERAZINE
  • N-T-BUTOXYCARBONYLPIPERAZINE
  • N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE
  • N-(TERT-BUTOXYCARBONYL)PIPERAZINE
  • 1-[(1,1-DiMethylethoxy)carbonyl]piperazine
  • 1-Piperazinecarboxylic Acid tert-Butyl Ester
  • 1-N-BOC-PIPERAZINE
  • 1-(TERT-BUTOXYCARBONYL)PIPERAZINE
  • N-(tert-Butoxycarbonyl)piperazine, tert-Butyl piperazine-1-carboxylate
  • tert-Butyl 1-piperazinecarboxylate, 97% 5GR
  • tert-Butyl 1-piperazincarboxylate
  • 1-Boc-piperazine, 98%, for synthesis
  • 1-(tert-Butoxycarbonyl)piperazine &gt
  • Avatrombopag Impurity 28
  • BOC-PAZ/1-Boc-piperazine
  • tert-Butyl 1-piperazinecarboxylate ISO 9001：2015 REACH
  • tert-butyl piperazine-1-carboylate
  • Tertbutylpiperzine-1-carboxylate (N-Boc-piperazine)
  • t-BUTYL PIPERZINE-1-CARBOXYLATE