ChemicalBook > CAS DataBase List > ME0328

ME0328

Product Name
ME0328
CAS No.
1445251-22-8
Chemical Name
ME0328
Synonyms
ME0328;ME0328 ，S7438;ME0328 ME-0328;ME0328 USP/EP/BP;4-Dihydro-4-oxo-3;ME0328, 10 mM in DMSO;ME0328; ME 0328; ME-0328;ME 0328, PARP-3 inhibitor;4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide;(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
CBNumber
CB82705099
Molecular Formula
C19H19N3O2
Formula Weight
321.37
MOL File
1445251-22-8.mol
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ME0328 Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22-43
Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0999
Product name
ME0328
Purity
≥98% (HPLC)
Packaging
5mg
Price
$88.4
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0999
Product name
ME0328
Purity
≥98% (HPLC)
Packaging
25mg
Price
$527
Updated
2022/05/15
Cayman Chemical
Product number
18488
Product name
ME0328
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
18488
Product name
ME0328
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
18488
Product name
ME0328
Purity
≥98%
Packaging
10mg
Price
$111
Updated
2024/03/01
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ME0328 Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

Uses

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

IC 50

ARTD3/PARP3: 0.89 μM (IC50); ARTD1/PARP1: 6.3 μM (IC50); ARTD2/PARP2: 10.8 μM (IC50); ARTD6/TNKS2: 34.3 μM (IC50); ARTD5/TNKS1: 47.3 μM (IC50); ARTD10/PARP10: 71.3 μM (IC50)

References

[1] ANDERS E. G. LINDGREN. PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3[J]. ACS Chemical Biology, 2013, 8 8: 1698-1703. DOI:10.1021/cb4002014

ME0328 Preparation Products And Raw materials

Raw materials

Preparation Products

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ME0328 Suppliers

China 110 India 1 United Kingdom 1 United States 14 Global 126
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from ME0328 manufacturers

Career Henan Chemical Co
Product
ME0328 1445251-22-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

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  • ME0328; ME 0328; ME-0328
  • 4-Dihydro-4-oxo-3
  • 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
  • ME0328
  • 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
  • (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
  • 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-
  • ME0328 USP/EP/BP
  • ME0328 ME-0328
  • (S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide
  • ME 0328, PARP-3 inhibitor
  • ME0328, 10 mM in DMSO
  • ME0328 ，S7438
  • 1445251-22-8
  • Inhibitors