CYCLO(-HIS-PRO)

Product Name: CYCLO(-HIS-PRO)
CAS No.: 53109-32-3
Chemical Name: CYCLO(-HIS-PRO)
Synonyms: Cyclo(HP);c(His-Pro);Cyclo(Pro-His);CYCLO(-HIS-PRO);HIS-PRO, CYCLIC;Cyclo-Pro-His-HO;CYCLO(HIS-PRO), >99%;Vitamin B6 Impurity 93;Cyclo(histidyl-proline);Protirelin EP Impurity E
CBNumber: CB8279260
Molecular Formula: C11H14N4O2
Formula Weight: 234.25
MOL File: 53109-32-3.mol

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CYCLO(-HIS-PRO) Property

Melting point:: 162-164 °C
Boiling point:: 659.3±48.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
form: A neat oil
pka: 12.73±0.40(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1
InChIKey: NAKUGCPAQTUSBE-IUCAKERBSA-N
SMILES: [C@@]12([H])CCCN1C(=O)[C@H](CC1=CNC=N1)NC2=O

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC49257
Product name: Cyclo(L-His-L-Pro)
Packaging: 25mg
Price: $83.5
Updated: 2021/12/16

ChemScene

Product number: CS-6320
Product name: Cyclo(his-pro)
Packaging: 5mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC49257
Product name: Cyclo(L-His-L-Pro)
Packaging: 50mg
Price: $140.5
Updated: 2021/12/16

ChemScene

Product number: CS-6320
Product name: Cyclo(his-pro)
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC49257
Product name: Cyclo(L-His-L-Pro)
Packaging: 100mg
Price: $225
Updated: 2021/12/16

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CYCLO(-HIS-PRO) Chemical Properties,Usage,Production

Uses

Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.

Definition

ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.

in vivo

Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect^[2].
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress^[3].

Animal Model:	Sixty two/three month-old male C57BL/6 mice (25-30 g)^[2]
Dosage:	1.8 mg/ear
Administration:	Topical application on the right ear; 30 min prior to TPA
Result:	Reduced TPA-induced ear oedema.

IC 50

NF-κB; Human Endogenous Metabolite

CYCLO(-HIS-PRO) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(-HIS-PRO) Suppliers

China 82 France 1 Germany 1 India 2 Switzerland 1 United Kingdom 1 United States 10 Global 98

BOC Sciences

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View Lastest Price from CYCLO(-HIS-PRO) manufacturers

Moxin Chemicals

Product: Protirelin EP Impurity E 53109-32-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%+
Supply Ability: 100000
Release date: 2025-02-10

53109-32-3, CYCLO(-HIS-PRO)Related Search:

2,5-Dimethylpiperazine 1-Methylpiperazin-2-one DL-2-AMINOPROPIONIC ANHYDRIDE CYCLO(-ALA-ALA) CIS-2,5-DIMETHYLPIPERAZINE CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID),Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-] Cyclo(L-Pro-L-Val-) CYCLO(-GLY-HIS) 1-ETHYL-2-METHYL-PIPERAZINE CYCLO(-GLY-PRO) (S)-3-METHYL-2-KETOPIPERAZINE CYCLO(-ALA-GLY) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE 1-ETHYLPIPERAZIN-2-ONE hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one (S)-1,4-DIAZABICYCLO[4.3.0]NONANE

(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione

Histidylproline diketopiperazine

histidylproline dioxopiperazine

Cyclo-Pro-His-HO

HIS-PRO, CYCLIC

CYCLO(-HIS-PRO)

Cyclo(histidyl-proline)

CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE

CYCLO(HIS-PRO), >99%

Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine, >99%

Protirelin EP Impurity E

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S,8aS)-

3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-histidyl-L-proline)

(3S,8aS)-3-(1H-Imidazol-4-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(his-pro) (Cyclo(histidyl-proline))

Endogenous Metabolite,active,orally,inflammatory,inhibit,tyreotropin-releasing,stress,NF-κB,Cyclo(his-pro),hormone,Nuclear factor-κB,cyclic,Cyclo(hispro),Histidylproline diketopiperazine,Cyclo(histidyl-proline),dipeptide,Cyclo(his pro),Inhibitor,Nuclear factor-kappaB,responses

Cyclo(HP)

(3S,8aS)-3-[(4-Imidazolyl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(Pro-His)

Vitamin B6 Impurity 93

Nebivolol Impurity 10 Monomer

c(His-Pro)

53109-32-3

Peptides

Releasing Factors

TRH

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical