ChemicalBook > CAS DataBase List > 2-Chloro-5-iodobenzoic acid
2-Chloro-5-iodobenzoic acid
- Product Name
- 2-Chloro-5-iodobenzoic acid
- CAS No.
- 19094-56-5
- Chemical Name
- 2-Chloro-5-iodobenzoic acid
- Synonyms
- SOTA-011;BUTTPARK 100\01-43;Englitin Impurity 13;Chloro-5-iodobenzoicA;3-Oxetanol,9-ethynyl-;Dagliar Net Impurity 69;2-Chloro-5-iodobenoicacid;2-Chloro-5-Iodbenzoic acid;2-CHLORO-5-IODOBENZOIC ACID;2-choloro-5-iodobenzoicacid
- CBNumber
- CB8283498
- Molecular Formula
- C7H4ClIO2
- Formula Weight
- 282.46
- MOL File
- 19094-56-5.mol
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2-Chloro-5-iodobenzoic acid Property
- Melting point:
- 157-161 °C (lit.)
- Boiling point:
- 353.1±27.0 °C(Predicted)
- Density
- 2.077±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.53±0.25(Predicted)
- color
- Yellow to light brown crystals or crystalline powder (light sensitive)
- Sensitive
- Light Sensitive
- BRN
- 2254110
- InChI
- InChI=1S/C7H4ClIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- GEBYSTBEDVQOTK-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(I)=CC=C1Cl
- CAS DataBase Reference
- 19094-56-5(CAS DataBase Reference)
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Safety
- Hazard Codes
- T,N,Xi
- Risk Statements
- 25-41-50/53
- Safety Statements
- 26-39-45-60-61
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- PackingGroup
- III
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 631736
- Product name
- 2-Chloro-5-iodobenzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $79.8
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 631736
- Product name
- 2-Chloro-5-iodobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $27
- Updated
- 2023/06/20
TCI Chemical
- Product number
- C2168
- Product name
- 2-Chloro-5-iodobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C2168
- Product name
- 2-Chloro-5-iodobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $206
- Updated
- 2025/07/31
TRC
- Product number
- C367570
- Product name
- 2-Chloro-5-iodobenzoic acid
- Packaging
- 25g
- Price
- $95
- Updated
- 2021/12/16
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2-Chloro-5-iodobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2-Chloro-5-iodobenzoic Acid is a useful synthetic intermediate. It is used to prepare metabotropic glutamate receptor subtype-??2 (mGluR2) positive allosteric modulator (PAM). It is also used to synthesize quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase.
Synthesis
89-54-3
19094-56-5
The general procedure for the synthesis of 2-chloro-5-iodobenzoic acid from 5-amino-2-chlorobenzoic acid was as follows: 123 g of 2-chloro-5-aminobenzoic acid was added to 2000 g of 20% aqueous sulfuric acid solution, and the temperature of the reaction was maintained at 0 to 10 °C. An aqueous sodium nitrite solution (51 g sodium nitrite dissolved in 200 g water) was prepared and added drop by drop to the reaction system, and the progress of the reaction was monitored by TLC (unfolding agent ratio of petroleum ether/ethyl acetate = 1:3) during the reaction. Upon completion of the reaction, 1.2 g of urea was added and cooled to 0 °C with stirring, potassium iodide solution (130 g KI dissolved in 500 g of water) was quickly added and stirring was continued until no bubbles were produced and then stirred for 30 min. The reaction mixture was filtered and washed with 200 g of water to give a brown solid. The solid was dissolved in 400 g of ethyl acetate and washed sequentially with 300 mL of 1N hydrochloric acid, 300 mL of 10% sodium bisulfite solution and 400 mL of saturated brine, and the organic phase was dried with magnesium sulfate. After drying, the crude product was obtained by concentration under reduced pressure at 50 °C. The crude product was dissolved in 400 mL of toluene and heated at 80 °C for 1 hour, then cooled to 0-5 °C for 1 hour for crystallization. Finally, it was dried under reduced pressure at 50 °C to give 191 g of 2-chloro-5-iodobenzoic acid as a pale yellow solid with 99.6% purity and 93.7% yield.
References
[1] Patent: CN106748721, 2017, A. Location in patent: Paragraph 0031; 0032
[2] RSC Advances, 2017, vol. 7, # 86, p. 54881 - 54891
2-Chloro-5-iodobenzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Chloro-5-iodobenzoic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2-Chloro-5-iodobenzoic acid 19094-56-5
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-02
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- 2-Chloro-5-iodobenzoic acid 19094-56-5
- Price
- US $1000.00-400.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-12
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2-Chloro-5-iodobenzoic acid 19094-56-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
19094-56-5, 2-Chloro-5-iodobenzoic acidRelated Search:
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2,3,5-Triiodobenzoic acid
4-(Chloromethyl)benzoic acid
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2-Iodobenzoic acid
2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE
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EMpagliflozin iMpurity 10
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Empagliflozin Impurity 32