2-Chloro-5-iodobenzoic acid

Product Name: 2-Chloro-5-iodobenzoic acid
CAS No.: 19094-56-5
Chemical Name: 2-Chloro-5-iodobenzoic acid
Synonyms: SOTA-011;BUTTPARK 100\01-43;Englitin Impurity 13;Chloro-5-iodobenzoicA;3-Oxetanol,9-ethynyl-;Dagliar Net Impurity 69;2-Chloro-5-iodobenoicacid;2-Chloro-5-Iodbenzoic acid;2-CHLORO-5-IODOBENZOIC ACID;2-choloro-5-iodobenzoicacid
CBNumber: CB8283498
Molecular Formula: C7H4ClIO2
Formula Weight: 282.46
MOL File: 19094-56-5.mol

More

Less

2-Chloro-5-iodobenzoic acid Property

Melting point:: 157-161 °C (lit.)
Boiling point:: 353.1±27.0 °C(Predicted)
Density: 2.077±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 2.53±0.25(Predicted)
color: Yellow to light brown crystals or crystalline powder (light sensitive)
Sensitive: Light Sensitive
BRN: 2254110
InChI: InChI=1S/C7H4ClIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)
InChIKey: GEBYSTBEDVQOTK-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(I)=CC=C1Cl
CAS DataBase Reference: 19094-56-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: T,N,Xi
Risk Statements: 25-41-50/53
Safety Statements: 26-39-45-60-61
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
PackingGroup: III
HS Code: 29163990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 631736
Product name: 2-Chloro-5-iodobenzoic acid
Purity: 97%
Packaging: 25g
Price: $79.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 631736
Product name: 2-Chloro-5-iodobenzoic acid
Purity: 97%
Packaging: 5g
Price: $27
Updated: 2023/06/20

TCI Chemical

Product number: C2168
Product name: 2-Chloro-5-iodobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: C2168
Product name: 2-Chloro-5-iodobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $206
Updated: 2025/07/31

TRC

Product number: C367570
Product name: 2-Chloro-5-iodobenzoic acid
Packaging: 5g
Price: $50
Updated: 2021/12/16

More

Less

2-Chloro-5-iodobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-5-iodobenzoic Acid is a useful synthetic intermediate. It is used to prepare metabotropic glutamate receptor subtype-??2 (mGluR2) positive allosteric modulator (PAM). It is also used to synthesize quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase.

Synthesis

89-54-3

19094-56-5

The general procedure for the synthesis of 2-chloro-5-iodobenzoic acid from 5-amino-2-chlorobenzoic acid was as follows: 123 g of 2-chloro-5-aminobenzoic acid was added to 2000 g of 20% aqueous sulfuric acid solution, and the temperature of the reaction was maintained at 0 to 10 °C. An aqueous sodium nitrite solution (51 g sodium nitrite dissolved in 200 g water) was prepared and added drop by drop to the reaction system, and the progress of the reaction was monitored by TLC (unfolding agent ratio of petroleum ether/ethyl acetate = 1:3) during the reaction. Upon completion of the reaction, 1.2 g of urea was added and cooled to 0 °C with stirring, potassium iodide solution (130 g KI dissolved in 500 g of water) was quickly added and stirring was continued until no bubbles were produced and then stirred for 30 min. The reaction mixture was filtered and washed with 200 g of water to give a brown solid. The solid was dissolved in 400 g of ethyl acetate and washed sequentially with 300 mL of 1N hydrochloric acid, 300 mL of 10% sodium bisulfite solution and 400 mL of saturated brine, and the organic phase was dried with magnesium sulfate. After drying, the crude product was obtained by concentration under reduced pressure at 50 °C. The crude product was dissolved in 400 mL of toluene and heated at 80 °C for 1 hour, then cooled to 0-5 °C for 1 hour for crystallization. Finally, it was dried under reduced pressure at 50 °C to give 191 g of 2-chloro-5-iodobenzoic acid as a pale yellow solid with 99.6% purity and 93.7% yield.

References

[1] Patent: CN106748721, 2017, A. Location in patent: Paragraph 0031; 0032
[2] RSC Advances, 2017, vol. 7, # 86, p. 54881 - 54891

2-Chloro-5-iodobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Chloro-5-iodobenzoic acid Suppliers

Americas 1 Belgium 1 Canada 1 CHINA 483 Europe 2 France 2 Germany 7 India 69 Japan 7 Switzerland 3 United Kingdom 14 United States 43 Global 633

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

GLR Innovations

Tel: +91 9891111994
Email: info@glrgroup.in
Country: India
ProdList: 4535
Advantage: 58

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

3A chemie

Tel: --
Fax: --
Email: info@3achemie.co.in
Country: India
ProdList: 25
Advantage: 58

Jigs chemical

Tel: --
Fax: --
Email: info@jigschemical.com
Country: India
ProdList: 318
Advantage: 58

Laksh Finechem Private Limited

Tel: --
Fax: --
Email: lakshfinechem@yahoo.com
Country: India
ProdList: 195
Advantage: 58

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: India
ProdList: 6905
Advantage: 58

Vindhya Pharma India Pvt., Ltd.

Tel: --
Fax: --
Email: dn@vindhyapharma.com
Country: India
ProdList: 51
Advantage: 58

Vignasai Laboratories Pvt., Ltd.

Tel: --
Fax: --
Email: info@vignasailabs.com
Country: India
ProdList: 169
Advantage: 58

Sibram Pharmaceutical

Tel: --
Fax: --
Email: contact@sibram.com
Country: India
ProdList: 136
Advantage: 58

RPN Organics Pvt., Ltd.

Tel: --
Fax: --
Email: rpnorganics@gmail.com
Country: India
ProdList: 40
Advantage: 58

Aruvi Labs

Tel: --
Fax: --
Email: info@aruvilabs.com
Country: India
ProdList: 68
Advantage: 58

Basr Fine Chemicals Private Limited

Tel: --
Fax: --
Country: India
ProdList: 632
Advantage: 58

Delta Finochem Pvt., Ltd.

Tel: --
Fax: --
Email: deltafinochem@gmail.com
Country: India
ProdList: 44
Advantage: 58

Ethachem

Tel: --
Fax: --
Email: ethachem@vsnl.com
Country: India
ProdList: 106
Advantage: 58

Hema Pharmaceuticals Pvt., Ltd.

Tel: --
Fax: --
Email: jignesh@hemapharma.com
Country: India
ProdList: 27
Advantage: 58

Ms Life Sciences

Tel: --
Fax: --
Country: India
ProdList: 341
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

aSai Vishwa Speciality Chemicals Pvt. Ltd.

Tel: --
Fax: --
Email: draay@asaivishwa.com
Country: India
ProdList: 27
Advantage: 58

Dynarx Technology India Limited

Tel: --
Fax: --
Email: sheela.a@dynarx.com
Country: India
ProdList: 24
Advantage: 58

TSK Lifesciences

Tel: --
Fax: --
Email: tsklifesciences@gmail.com
Country: India
ProdList: 246
Advantage: 58

ALR Fine Chemicals Pvt Ltd

Tel: --
Fax: --
Country: India
ProdList: 283
Advantage: 58

Clearsynth Labs

Tel: --
Fax: --
Email: fo@clearsynth.com
Country: India
ProdList: 3887
Advantage: 58

Rivashaa Agrotech Biopharma Pvt. Ltd.

Tel: --
Fax: --
Email: source@rivashaa.com
Country: India
ProdList: 986
Advantage: 58

Cefa-Cilinas Biotics Pvt., Ltd.

Tel: --
Fax: --
Email: info@cefacilinas.com
Country: India
ProdList: 53
Advantage: 58

SUVEN LIFE SCIENCES LTD

Tel: --
Fax: --
Email: info@suven.com
Country: India
ProdList: 95
Advantage: 58

Glory Pharmachem India Private Ltd.

Tel: --
Fax: --
Email: psreddy722@yahoo.com
Country: India
ProdList: 4
Advantage: 58

Darsh PharmaChem Pvt. Ltd.

Tel: --
Fax: --
Email: info@darshpharmachem.com
Country: India
ProdList: 27
Advantage: 58

Visa Chem Pvt. Ltd.

Tel: --
Fax: --
Email: info@visachemlabs.com
Country: India
ProdList: 48
Advantage: 58

Seema Finechem Industry LLP

Tel: --
Fax: --
Country: India
ProdList: 67
Advantage: 58

Omkar Speciality Chemicals Ltd

Tel: --
Fax: --
Email: info@omkarchemicals.com
Country: India
ProdList: 75
Advantage: 58

Sai Carbohydrates

Tel: --
Fax: --
Email: info@saicarbohydrates.com
Country: India
ProdList: 54
Advantage: 58

PVR Life Sciences

Tel: --
Fax: --
Country: India
ProdList: 34
Advantage: 58

Visa Chem Private Limited

Tel: --
Fax: --
Country: India
ProdList: 59
Advantage: 58

Hema Pharmaceuticals Pvt. Ltd.

Tel: --
Fax: --
Country: India
ProdList: 24
Advantage: 58

Triveni Interchem Private Limited (Group Of Triveni...

Tel: --
Fax: --
Country: India
ProdList: 497
Advantage: 58

Mallu Chemicals Private Limited

Tel: --
Fax: --
Country: India
ProdList: 6
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

LOBA CHEMIE PVT.LTD.

Tel: --
Fax: --
Email: info@lobachemie.com
Country: India
ProdList: 3075
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

More

Less

View Lastest Price from 2-Chloro-5-iodobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-5-iodobenzoic acid 19094-56-5
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-12-02

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 2-Chloro-5-iodobenzoic acid 19094-56-5
Price: US $1000.00-400.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-12

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-5-iodobenzoic acid 19094-56-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

19094-56-5, 2-Chloro-5-iodobenzoic acidRelated Search:

EPA 4-Iodobenzoic acid 3-Chloroperoxybenzoic acid 2,3,5-Triiodobenzoic acid 4-(Chloromethyl)benzoic acid Methyl 2-iodobenzoate 2-Iodobenzoic acid 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Acetoxy Empagliflozin (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol EMpagliflozin iMpurity 10 Butanoic acid, 4-chloro-3-hydroxy-, (3S)- Methanone, (5-chloro-2-iodophenyl)(2-fluorophenyl)- (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene Empagliflozin Impurity 32

2-CHLORO-5-IODOBENZOIC ACID

BUTTPARK 100\01-43

2-Chloro-5-iodobenzoic acid, 98+%

SOTA-011

2 - chloro - 5 - iodine benzoic acid

Chloro-5-iodobenzoicA

2-Chloro-5-iodobnezoic Acid

2-choloro-5-iodobenzoicacid

2-Chloro-5-Iodbenzoic acid

2-Chloro-5-iodobenzoic acid 98%

2-CHLORO 5-IODO BENZOIC ACID 19094-56-5

Englitin Impurity 13

2-Chloro-5-iodobenzoic Acid &gt

5-iodo-2-chlorobenzoic acid

3-Oxetanol,9-ethynyl-

2-Chloro-5-lodobenzoic Acid

2-Chloro-5-iodiobenzoic acid

2-ChIoro-5-Iodo benzoic Acid

Dagliar Net Impurity 69

2-Chloro-5-iodobenoicacid

19094-56-5

19094-56-6

9094-56-5

C7H4CIIO2

C7H4O2ClI

Organic Building Blocks

C7

Carbonyl Compounds

Carboxylic Acids

Building Blocks

C7

Carbonyl Compounds

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Phenylacetic acid

Acids & Esters

Chlorine Compounds

Iodine Compounds

bc0001

19094-56-5