ChemicalBook > CAS DataBase List > 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER

4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER

Product Name
4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER
CAS No.
204707-42-6
Chemical Name
4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER
Synonyms
METHYL 4-FLUORO-2-METHOXYBENZOATE;RARECHEM AL BF 1023;Methyl 2-methoxy-4-fluorobenzoate;Methyl 4-fluoro-2-Methoxybenzoate, 97+%;2-Fluoro-2-methoxybenzoic acid methyl ester;4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER;Benzoic acid, 4-fluoro-2-methoxy-, methyl ester;JR-13782, Methyl 4-fluoro-2-methoxybenzoate, 97%
CBNumber
CB8284329
Molecular Formula
C9H9FO3
Formula Weight
184.16
MOL File
204707-42-6.mol
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4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Property

Melting point:
134-136°C
Boiling point:
232℃
Density 
1.184
Flash point:
91℃
storage temp. 
Sealed in dry,Room Temperature
form 
solid
Appearance
Off-white to yellow Solid-Liquid Mixture
InChI
InChI=1S/C9H9FO3/c1-12-8-5-6(10)3-4-7(8)9(11)13-2/h3-5H,1-2H3
InChIKey
LJUAEPNTXDJBRX-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=C(F)C=C1OC
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
VBP00106
Product name
Methyl-4-fluoro-2-methoxybenzoate
Purity
AldrichCPR
Packaging
1G
Price
$185
Updated
2025/07/31
TRC
Product number
M305793
Product name
Methyl4-Fluoro-2-methoxybenzoate
Packaging
10mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
2623-3-67
Product name
Methyl 4-fluoro-2-methoxybenzoate
Packaging
1g
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC200606
Product name
Methyl4-fluoro-2-methoxybenzoate
Packaging
1g
Price
$37
Updated
2021/12/16
SynQuest Laboratories
Product number
2623-3-67
Product name
Methyl 4-fluoro-2-methoxybenzoate
Packaging
5G
Price
$183
Updated
2021/12/16
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4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 4-fluoro-2-methoxybenzoate ?is used as a catalyst, kinase inhibitors and pharmaceutical intermediates.

Synthesis

67-56-1

395-82-4

204707-42-6

General procedure for the synthesis of methyl 4-fluoro-2-methoxybenzoate from methanol and 4-fluoro-2-methoxybenzoic acid: 4-fluoro-2-methoxybenzoic acid (1.7 g, 10 mmol) was dissolved in methanol (100 mL) at 0 °C and thionyl chloride (5.73 g, 48 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator under vacuum. Saturated aqueous sodium bicarbonate (50 mL) was added to the residue to neutralize the unreacted thionyl chloride, followed by extraction with ethyl acetate (100 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under vacuum to afford the target product methyl 4-fluoro-2-methoxybenzoate (1.3 g, 70% yield).

References

[1] Patent: CN106146493, 2016, A. Location in patent: Paragraph 0534; 0535; 0536; 0537
[2] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 00254; 00255
[3] Patent: US9206128, 2015, B2. Location in patent: Page/Page column 135; 136

4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Suppliers

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View Lastest Price from 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co
Product
Methyl 4-fluoro-2-methoxybenzoate 204707-42-6
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

204707-42-6, 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTERRelated Search:

Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98% Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate METHYL 4-FLUORO-2-HYDROXYBENZOATE Benzoic acid, 4-fluoro-3-methoxy-5-nitro-, methyl ester Methyl 4-fluoro-3-nitrobenzoate Methyl4-fluoro-3-iodobenzoate Benzoic acid，4-fluoro-2,6-dimethyl-， methyl ester Methyl 4-fluoro-3-(trifluoroMethyl)benzoate Methyl 4-fluoro-3-methylbenzoate METHYL 4-FLUORO-3-HYDROXYBENZOATE methyl 4-fluoro-3-methoxyphenylacetate RARECHEM AL BF 0506 methyl 4-fluoro-2-methyl-3-nitrobenzoate 4-FLUORO-2-METHOXYBENZALDEHYDE 4-FLUORO-2-HYDROXYBENZOIC ACID 4-FLUORO-2-HYDROXYBENZALDEHYDE 4-Fluoro-2-methoxybenzoic acid 5-FLUORO-2-METHYLANISOLE

  • 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER
  • Methyl 4-fluoro-2-Methoxybenzoate, 97+%
  • METHYL 4-FLUORO-2-METHOXYBENZOATE
  • RARECHEM AL BF 1023
  • 2-Fluoro-2-methoxybenzoic acid methyl ester
  • Methyl 2-methoxy-4-fluorobenzoate
  • JR-13782, Methyl 4-fluoro-2-methoxybenzoate, 97%
  • Benzoic acid, 4-fluoro-2-methoxy-, methyl ester
  • 204707-42-6
  • Aromatic Esters
  • Acids & Esters
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds