ChemicalBook > CAS DataBase List > 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER

4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER

Product Name: 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER
CAS No.: 204707-42-6
Chemical Name: 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER
Synonyms: METHYL 4-FLUORO-2-METHOXYBENZOATE;RARECHEM AL BF 1023;Methyl 2-methoxy-4-fluorobenzoate;Methyl 4-fluoro-2-Methoxybenzoate, 97+%;2-Fluoro-2-methoxybenzoic acid methyl ester;4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER;Benzoic acid, 4-fluoro-2-methoxy-, methyl ester;JR-13782, Methyl 4-fluoro-2-methoxybenzoate, 97%
CBNumber: CB8284329
Molecular Formula: C9H9FO3
Formula Weight: 184.16
MOL File: 204707-42-6.mol

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4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Property

Melting point:: 134-136°C
Boiling point:: 232℃
Density: 1.184
Flash point:: 91℃
storage temp.: Sealed in dry,Room Temperature
form: solid
Appearance: Off-white to yellow Solid-Liquid Mixture
InChI: InChI=1S/C9H9FO3/c1-12-8-5-6(10)3-4-7(8)9(11)13-2/h3-5H,1-2H3
InChIKey: LJUAEPNTXDJBRX-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(F)C=C1OC

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2916310090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00106
Product name: Methyl-4-fluoro-2-methoxybenzoate
Purity: AldrichCPR
Packaging: 1G
Price: $185
Updated: 2025/07/31

TRC

Product number: M305793
Product name: Methyl4-Fluoro-2-methoxybenzoate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC200606
Product name: Methyl4-fluoro-2-methoxybenzoate
Packaging: 1g
Price: $37
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2623-3-67
Product name: Methyl 4-fluoro-2-methoxybenzoate
Packaging: 1g
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0104917
Product name: 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $115.7
Updated: 2021/12/16

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4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 4-fluoro-2-methoxybenzoate ?is used as a catalyst, kinase inhibitors and pharmaceutical intermediates.

Synthesis

67-56-1

395-82-4

204707-42-6

General procedure for the synthesis of methyl 4-fluoro-2-methoxybenzoate from methanol and 4-fluoro-2-methoxybenzoic acid: 4-fluoro-2-methoxybenzoic acid (1.7 g, 10 mmol) was dissolved in methanol (100 mL) at 0 °C and thionyl chloride (5.73 g, 48 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator under vacuum. Saturated aqueous sodium bicarbonate (50 mL) was added to the residue to neutralize the unreacted thionyl chloride, followed by extraction with ethyl acetate (100 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under vacuum to afford the target product methyl 4-fluoro-2-methoxybenzoate (1.3 g, 70% yield).

References

[1] Patent: CN106146493, 2016, A. Location in patent: Paragraph 0534; 0535; 0536; 0537
[2] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 00254; 00255
[3] Patent: US9206128, 2015, B2. Location in patent: Page/Page column 135; 136

4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER Suppliers

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View Lastest Price from 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co

Product: Methyl 4-fluoro-2-methoxybenzoate 204707-42-6
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-09

204707-42-6, 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTERRelated Search:

Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98% Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate METHYL 4-FLUORO-2-HYDROXYBENZOATE Benzoic acid, 4-fluoro-3-methoxy-5-nitro-, methyl ester Methyl 4-fluoro-3-nitrobenzoate Methyl4-fluoro-3-iodobenzoate Benzoic acid，4-fluoro-2,6-dimethyl-， methyl ester Methyl 4-fluoro-3-(trifluoroMethyl)benzoate Methyl 4-fluoro-3-methylbenzoate METHYL 4-FLUORO-3-HYDROXYBENZOATE methyl 4-fluoro-3-methoxyphenylacetate RARECHEM AL BF 0506 methyl 4-fluoro-2-methyl-3-nitrobenzoate 4-FLUORO-2-METHOXYBENZALDEHYDE 4-FLUORO-2-HYDROXYBENZOIC ACID 4-FLUORO-2-HYDROXYBENZALDEHYDE 4-Fluoro-2-methoxybenzoic acid 5-FLUORO-2-METHYLANISOLE

4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER

Methyl 4-fluoro-2-Methoxybenzoate, 97+%

METHYL 4-FLUORO-2-METHOXYBENZOATE

RARECHEM AL BF 1023

2-Fluoro-2-methoxybenzoic acid methyl ester

Methyl 2-methoxy-4-fluorobenzoate

JR-13782, Methyl 4-fluoro-2-methoxybenzoate, 97%

Benzoic acid, 4-fluoro-2-methoxy-, methyl ester

204707-42-6

Aromatic Esters

Acids & Esters

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds