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PFI-2 (hydrochloride)

Product Name
PFI-2 (hydrochloride)
CAS No.
1627607-87-7
Chemical Name
PFI-2 (hydrochloride)
Synonyms
(R)-PFI-2;PFI-2 HCl salt;PFI-2 (hydrochloride);(R)-PFI-2 (hydrochloride);PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2;(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride;(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride;macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride
CBNumber
CB83041444
Molecular Formula
C23H26ClF4N3O3S
Formula Weight
535.98
MOL File
1627607-87-7.mol
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PFI-2 (hydrochloride) Property

Melting point:
>209°C (dec.)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1408
Product name
(R)-PFI-2
Purity
≥97% (HPLC)
Packaging
5mg
Price
$196
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1408
Product name
(R)-PFI-2
Purity
≥97% (HPLC)
Packaging
25mg
Price
$769
Updated
2024/03/01
Cayman Chemical
Product number
14678
Product name
(R)-PFI-2 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
14678
Product name
(R)-PFI-2 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
14678
Product name
(R)-PFI-2 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$330
Updated
2024/03/01
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PFI-2 (hydrochloride) Chemical Properties,Usage,Production

Description

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. Its enantiomer, (S)-PFI-2 , is 500-fold less active (IC50 = 1 μM). See the Structural Genomics Consortium (SGC) website for more information.

Uses

(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide Hydrochloride known as (-)-PFI-2 HCl is a cell permeable inhibitor of SET Domain-Containing protein 7/9 (SET 7/9) which plays a role in tumorigenesis in cell cancer lines.

Biochem/physiol Actions

(R)-PFI-2 is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (also known as SET9). (R)-PFI-2 has an IC50 value of 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. For full characterization details, please visit the PFI-2 probe summary on the Structural Genomics Consortium (SGC) website.(S)-PFI-2, an enantiomer of (R)-PFI-2, is used as a negative control. (S)-PFI-2 is available from Sigma. To learn more about and purchase (S)-PFI-2, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at -20°C

References

1)?Barsyte-Lovejoy?et al.?(2014),?(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells;?Proc. Natl. Acad. Sci. USA?111?12853

PFI-2 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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PFI-2 (hydrochloride) Suppliers

China 59 United Kingdom 1 United States 12 Global 72
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
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58
ApexBio Technology
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sales@apexbt.com
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United States
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6251
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58
BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Focus Biomolecules
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sales@focusbiomolecules.com
Country
United States
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Cayman Chemical Company
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
MedChemExpress
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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Riedel-de Haen AG
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View Lastest Price from PFI-2 (hydrochloride) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
PFI-2 hydrochloride 1627607-87-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
PFI-2 hydrochloride 1627607-87-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

1627607-87-7, PFI-2 (hydrochloride)Related Search:

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  • PFI-2 (hydrochloride)
  • PFI-2 HCl salt
  • (R)-PFI-2 (hydrochloride)
  • (R)-PFI-2
  • PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2
  • (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride
  • (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride
  • macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride
  • 1627607-87-7
  • C23H25F4N3O3SHCl
  • C23H26ClF4N3O3S
  • API