ChemicalBook > CAS DataBase List > Azide-PEG3-Tos

Azide-PEG3-Tos

Product Name: Azide-PEG3-Tos
CAS No.: 178685-33-1
Chemical Name: Azide-PEG3-Tos
Synonyms: 2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;N?-PEG?-OTs;N3-PEG3-OTs;N3-PEG3-Tos;N3-PEG3-OTos;Azide-PEG3-Tos;Azido-PEG3-Ots;Ethylene glycol 2-azidoethyl ether tosylate;Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester;Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 4-methylbenzenesulfonate (ester)
CBNumber: CB83062331
Molecular Formula: C13H19N3O5S
Formula Weight: 329.37
MOL File: 178685-33-1.mol

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Azide-PEG3-Tos Property

storage temp.: Storage temp. 2-8°C
solubility: Soluble in DMSO, DCM, DMF
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C13H19N3O5S/c1-12-2-4-13(5-3-12)22(17,18)21-11-10-20-9-8-19-7-6-15-16-14/h2-5H,6-11H2,1H3
InChIKey: PTOJCKLTCKYNFG-UHFFFAOYSA-N
SMILES: S(C1C=CC(C)=CC=1)(=O)(=O)OCCOCCOCCN=[N+]=[N-]

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22769
Product name: Azide-PEG3-Tos
Purity: 98%
Packaging: 250mg
Price: $360
Updated: 2021/12/16

Activate Scientific

Product number: AS107893
Product name: N3-PEG3-Tos
Purity: 97%
Packaging: 1g
Price: $618
Updated: 2021/12/16

BroadPharm

Product number: BP-22769
Product name: Azide-PEG3-Tos
Purity: 98%
Packaging: 1g
Price: $750
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1094
Product name: Azide-PEG3-Tos
Packaging: 250mg
Price: $753
Updated: 2021/12/16

Matrix Scientific

Product number: 179948
Product name: 2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
Purity: 95%
Packaging: 5g
Price: $1403
Updated: 2021/12/16

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Azide-PEG3-Tos Chemical Properties,Usage,Production

Description

Azide-PEG3-Tos is a heterobifunctional PEG linker.The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Tosyl group is a good leaving group for nucleophilic substitution reactions.

Uses

Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs; Non-cleavable Linker

References

[1] Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431. DOI:10.1021/ma4005633
[2] Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.

Azide-PEG3-Tos Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Azide-PEG3-Tos manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 2-(2-(2-azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate 178685-33-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

Xian confluore Biological Technology Co., Ltd.

Product: Azido-PEG3-Tos 178685-33-1
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-23

178685-33-1, Azide-PEG3-TosRelated Search:

Azido-PEG3-Sulfone-PEG4-acid Bromo-PEG3-azide Azide-PEG3-Sulfone-PEG3-Azide Azido-PEG3-NHS ester 1,11-DIAZIDO-3,6,9-TRIOXAUNDECANE 2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL N3-PEG3-Hydrazide 11-AZIDO-3 6 9-TRIOXAUNDECAN-1-AMINE Azido-PEG3-Sulfone-PEG4-t-butyl ester Azido-dPEG4-acid N3-PEG3-tBu L-Tyrosine benzyl ester p-toluenesulfonate 1,14-Diazido-3,6,9,12-tetraoxatetradecane 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester 2-[2-(2-Azidoethoxy)ethoxy]ethanamine alpha, oMega-DisucciniMidyl hexaethylene glycol 2-(2-Azidoethoxy)ethanol H2N-PEG11-CH2CH2COOH

Azido-PEG3-Ots

2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

Azide-PEG3-Tos

N3-PEG3-Tos

Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 4-methylbenzenesulfonate (ester)

N3-PEG3-OTs

Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester

N3-PEG3-Tos/Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 1-(4-methylbenzenesulfonate)

N?-PEG?-OTs

N3-PEG3-OTos

Ethylene glycol 2-azidoethyl ether tosylate

178685-33-1

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