Bromoacetamido-PEG4-Acid

Product Name: Bromoacetamido-PEG4-Acid
CAS No.: 1807518-67-7
Chemical Name: Bromoacetamido-PEG4-Acid
Synonyms: CAS_1807518-67-7;BrCH2CONH-PEG4-acid;Bromoacetamido-PEG5-acid;Bromoacetamido-PEG4-Acid;Bromoacetamido-PEG4-CH2CH2COOH;1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid;Propanoic acid, 3-[(14-bromo-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-;Bromoacetamido-PEG4-CH2CH2COOH/Propanoic acid, 3-[(14-bromo-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-
CBNumber: CB83062432
Molecular Formula: C13H24BrNO7
Formula Weight: 386.24
MOL File: 1807518-67-7.mol

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Bromoacetamido-PEG4-Acid Property

Boiling point:: 557.7±50.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in Water, DCM
form: Viscous Liquid
pka: 4.28±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22763
Product name: Bromoacetamido-PEG4-acid
Purity: 98%
Packaging: 100mg
Price: $290
Updated: 2021/12/16

BroadPharm

Product number: BP-22763
Product name: Bromoacetamido-PEG4-acid
Purity: 98%
Packaging: 250mg
Price: $480
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1311
Product name: Bromoacetamido-PEG4-Acid
Packaging: 100mg
Price: $565
Updated: 2021/12/16

BroadPharm

Product number: BP-22763
Product name: Bromoacetamido-PEG4-acid
Purity: 98%
Packaging: 500mg
Price: $780
Updated: 2021/12/16

Activate Scientific

Product number: AS107816
Product name: Bromoacetamido-PEG4-CH2CH2COOH
Purity: 97%
Packaging: 1g
Price: $969
Updated: 2021/12/16

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Bromoacetamido-PEG4-Acid Chemical Properties,Usage,Production

Description

Bromoacetamido-PEG4-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC 50

PEGs; Cleavable Linker

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Bromoacetamido-PEG4-Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Bromoacetamido-PEG4-Acid Suppliers

China 30 United Kingdom 1 United States 5 Global 36

Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
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Zhengzhou Acme Chemical Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
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Email: psaitong@jm-bio.com
Country: China
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Amatek Scientific Co. Ltd.

Tel: 0512-56316828
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SHANGHAI FDC-CHEMICAL CO.,LTD

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Xi'an Confluore Biological Technology Co., Ltd.

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Jiangsu aikang biomedical research and development co., LTD

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TargetMol Chemicals Inc.

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Hangzhou Huarong Pharm Co., Ltd.

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Wuhan Borenpharm Co., Ltd

Tel: 027-65563561 18717150066
Fax: 027-59218822
Email: 3207347307@qq.com
Country: CHINA
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View Lastest Price from Bromoacetamido-PEG4-Acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: BrCH2CONH-PEG4-acid 1807518-67-7
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-25

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Bromoacetamido-PEG4-Acid

Bromoacetamido-PEG5-acid

Bromoacetamido-PEG4-CH2CH2COOH

CAS_1807518-67-7

BrCH2CONH-PEG4-acid

1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid

Bromoacetamido-PEG4-CH2CH2COOH/Propanoic acid, 3-[(14-bromo-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-

Propanoic acid, 3-[(14-bromo-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-

1807518-67-7

C13H24BrNO7