Rivastigmine

Product Name: Rivastigmine
CAS No.: 123441-03-2
Chemical Name: Rivastigmine
Synonyms: RIVASTIGMINE HYDROGEN TARTRATE;EXELON;Rivastigmine base;mine;Rivastig;Kabaratin;cabalatine;Revastigmine;RIVASTIGMINE;RivastigiMine
CBNumber: CB8328151
Molecular Formula: C14H22N2O2
Formula Weight: 250.34
MOL File: 123441-03-2.mol

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Rivastigmine Property

alpha: D20 -32.1° (c = 5 in ethanol)
Boiling point:: 316.2±34.0 °C(Predicted)
Density: 1.038±0.06 g/cm3(Predicted)
Flash point:: 145℃
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: Powder
pka: pKa 8.99 (Uncertain)
color: Colorless to light yellow
CAS DataBase Reference: 123441-03-2(CAS DataBase Reference)

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Safety

RIDADR: UN 2810 6.1 / PGIII
HS Code: 2924296000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3343
Product name: Rivastigmine
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 0.2ML
Price: $228
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1604836
Product name: Rivastigmine
Packaging: 0.1ml
Price: $460
Updated: 2024/03/01

TRC

Product number: R540995
Product name: (S)-Rivastigmine
Packaging: 2g
Price: $350
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 61620
Product name: (S)-Rivastigmine
Packaging: 5G
Price: $1380
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008913
Product name: Rivastigmine
Purity: 95.00%
Packaging: 5G
Price: $2945.25
Updated: 2021/12/16

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Rivastigmine Chemical Properties,Usage,Production

Uses

Antidepressant

Definition

ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.

brand name

Exelon (Novartis).

General Description

Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease.

Pharmacokinetics

Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys.

Clinical Use

Mild-moderate dementia in Alzheimer’s disease
Idiopathic Parkinson’s disease

Drug interactions

Potentially hazardous interactions with other drugs
Muscle relaxants: enhances effect of suxamethonium; antagonises effect of non-depolarising muscle relaxants.

Metabolism

Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds.

Rivastigmine Preparation Products And Raw materials

Raw materials

Preparation Products

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Rivastigmine Suppliers

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View Lastest Price from Rivastigmine manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Rivastigmine 123441-03-2
Price: US $3810.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2021-06-03

Hebei Weibang Biotechnology Co., Ltd

Product: Rivastigmine 123441-03-2
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-08-27

Hebei Mojin Biotechnology Co., Ltd

Product: Rivastigmine 123441-03-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-01

123441-03-2, RivastigmineRelated Search:

Ethyl acetate Ethylparaben 4-Aminobenzoic acid Tris(trimethylsilyl)phosphate Urethane ISOXADIFEN-ETHYL Methyl anthranilate PHENYL VALERATE 3-Dimethylaminopropylamine Neostigmine bromide 4-Dimethylaminobenzaldehyde Diphenyl ether Dimethyl phthalate Ethanol Phenyl salicylate POLYURETHANE PHENYL RESIN Rivastigmine tartrate,Rivastigmine-d6 tartarate,RIVASTIGMINE TARTRATE SALT,Rivastigmine tartrate; SDZ-ENA 713

(S)-N-Ethyl-N-Methyl- 3-[1-(diMethylaMino)ethyl]- phenyl carbaMate

S-RivastigMine

CarbaMic acid, N-ethyl-N-Methyl-, 3-[(1S)-1-(diMethylaMino)ethyl]phenyl ester

RivastigiMine

Rivastigmine base

bis(sulfanylidene)ruthenium

(S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate

Revastigmine

N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester

Revastigmine (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate

Rivastigmine Base/ Tartrate

EXELON

RIVASTIGMINE

RIVASTIGMINE HYDROGEN TARTRATE

RIVASTIGIMINE(FORR&DONLY)

3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate

Ethylmethylcarbamic acid 3-((1S)-1-(dimethylamino)ethyl)phenyl ester

3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate

Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester

Carbamic acid, ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl ester, (S)-

Ena 713 free base

Unii-pki06m3iw0

Rivastigmine (0.1 mL)

(S)-3-[1-(diMethylaMino)ethyl]phenyl N-ethyl-N-MethylcarbaMate

Rivastigmine for system suitability CRS

mine

Rivastig

Rivastigmine USP/EP/BP

Rivastigmine intermediate,Rivastigmine

Rivastigmine (1604836)

Benzo[b]thiophene-2-carboxylicacid,3-chloro-5,10-dimethoxy-,methylester

Rivastigmine Monomer

Rivastigmine Impurity

cabalatine

Kabaratin

123441-03-2

320-67-4