8-Quinolinesulfonyl chloride
- Product Name
- 8-Quinolinesulfonyl chloride
- CAS No.
- 18704-37-5
- Chemical Name
- 8-Quinolinesulfonyl chloride
- Synonyms
- QUINOLINE-8-SULFONYL CHLORIDE;QSC;SKL275;AKOS B019400;ART-CHEM-BB B019400;8-Quinolinesulfonyl;8-quinolylsulfonylchloride;Chinolin-8-sulfonylchlorid;8-Quinolylsulfonyl chloride;8-Chlorosulfonyl-1-benzazine
- CBNumber
- CB8329163
- Molecular Formula
- C9H6ClNO2S
- Formula Weight
- 227.67
- MOL File
- 18704-37-5.mol
8-Quinolinesulfonyl chloride Property
- Melting point:
- 126-129 °C(lit.)
- Boiling point:
- 306°C
- Density
- 1.483±0.06 g/cm3(Predicted)
- Flash point:
- 306°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: soluble10mg/mL, clear, colorless to light yellow
- pka
- 0?+-.0.17(Predicted)
- form
- powder to crystal
- color
- White to Orange to Green
- Sensitive
- Moisture Sensitive
- BRN
- 156347
- InChI
- InChI=1S/C9H6ClNO2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H
- InChIKey
- JUYUYCIJACTHMK-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2S(Cl)(=O)=O)C=CC=1
- CAS DataBase Reference
- 18704-37-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Sulfonyl chloride, 8-quinoline-(18704-37-5)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- RTECS
- VC2830000
- F
- 3-10-21
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29334990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- Q1506
- Product name
- 8-Quinolinesulfonyl chloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $49.97
- Updated
- 2025/07/31
- Product number
- 22695
- Product name
- 8-Quinolinesulfonyl chloride
- Purity
- ≥96.0% (AT)
- Packaging
- 5g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- Q0016
- Product name
- Quinoline-8-sulfonyl Chloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- Q0016
- Product name
- Quinoline-8-sulfonyl Chloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $229
- Updated
- 2025/07/31
- Product number
- Q1506
- Product name
- 8-Quinolinesulfonyl chloride
- Purity
- 98%
- Packaging
- 10g
- Price
- $69.93
- Updated
- 2025/07/31
8-Quinolinesulfonyl chloride Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
8-Quinolinesulfonyl chloride was used as a coupling reagent in oligonucleotide synthesis. It was also used in the synthesis of olefins from secondary esters at moderate temperature
General Description
8-Quinolinesulfonyl chloride reacts with aromatic/heterocyclic sulfonamides containing a free amino, imino, hydrazino or hydroxyl group to form water-soluble compounds.
Synthesis
85-48-3
18704-37-5
The general procedure for the synthesis of quinoline-8-sulfonyl chloride from quinoline-8-sulfonic acid is as follows: chlorosulfonic acid (6.0 g, 51.5 mmol) was added to a reaction vessel fitted with a magnetic stirrer under nitrogen protection. Quinoline (1.0 g, 7.74 mmol) was slowly added under cooling in an ice bath. Subsequently, the reaction system was gradually warmed to 140 °C and the reaction was continuously stirred at this temperature for 10 hours. Upon completion of the reaction, the system was cooled to 40 °C and thionyl chloride (2.0 g, 16.0 mmol) was added dropwise. Then, the reaction temperature was raised to 70 °C and the reaction continued to be stirred for 4 hours. At the end of the reaction, the reaction system was allowed to cool naturally to room temperature, and the reaction solution was slowly poured into ice water, which immediately precipitated a solid. After stirring the mixture for 30 min, the solid product was collected by filtration and dried under vacuum to give quinoline-8-sulfonyl chloride (1.7 g, 99% yield). Mass spectrometry analysis showed m/z: 228.0 (M+1).
References
[1] Patent: WO2018/156297, 2018, A1. Location in patent: Paragraph 0101; 0114; 0115; 0116; 0117
[2] Synthesis, 2004, # 18, p. 2999 - 3004
[3] Chemische Berichte, 1908, vol. 41, p. 942
[4] Chemische Berichte, 1886, vol. 19, p. 925
8-Quinolinesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Quinolinesulfonyl chloride manufacturers
- Product
- 8-Quinolinesulfonyl chloride 18704-37-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- 8-Quinolinesulfonyl chloride 18704-37-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 95%,97%
- Supply Ability
- As your request
- Release date
- 2025-03-19
- Product
- 8-Quinolinesulfonyl chloride 18704-37-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-28