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Diethyl bromodifluoromethanephosphonate

Product Name
Diethyl bromodifluoromethanephosphonate
CAS No.
65094-22-6
Chemical Name
Diethyl bromodifluoromethanephosphonate
Synonyms
DIETHYL (BROMODIFLUOROMETHYL)PHOSPHONATE;BROMODIFLUOROMETHYL DIETHYLPHOSPHONATE;BROMODIFLUOROMETHANE DIETHYL PHOSPHATE;Diethyl bromodifluoromethanephosphonat;Diethyl bromodifluoromethanephosphonate;Bromodifluoromethyldiethylphosphonate97%;Bromodifluoromethyl diethylphosphonate 97%;Diethyl P-(bromodifluoromethyl)phosphonate;Diethyl (Bromodifluoromethyl)phosphonate >Diethyl [bromo(difluoro)methyl]phosphonate 97%
CBNumber
CB8333674
Molecular Formula
C5H10BrF2O3P
Formula Weight
267.01
MOL File
65094-22-6.mol
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Diethyl bromodifluoromethanephosphonate Property

Boiling point:
40-41 °C/0.05 mmHg (lit.)
Density 
1.503 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.417(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, Ethyl Acetate
form 
liquid
Specific Gravity
1.503
color 
colorless
Water Solubility 
Not miscible or difficult to mix in water.
BRN 
1944045
CAS DataBase Reference
65094-22-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
21/22-36/38-38-36
Safety Statements 
26-36/37/39-60-37-23
RIDADR 
3278
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
No
HazardClass 
IRRITANT, IRRITANT-HARMFUL
PackingGroup 
III
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
411361
Product name
Diethyl (bromodifluoromethyl)phosphonate
Purity
96%
Packaging
5g
Price
$102
Updated
2024/03/01
TCI Chemical
Product number
D3071
Product name
Diethyl (Bromodifluoromethyl)phosphonate
Purity
>97.0%(GC)
Packaging
5g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
D3071
Product name
Diethyl (Bromodifluoromethyl)phosphonate
Purity
>97.0%(GC)
Packaging
25g
Price
$149
Updated
2024/03/01
Alfa Aesar
Product number
L16715
Product name
Diethyl (bromodifluoromethyl)phosphonate, 97%
Packaging
1g
Price
$24.65
Updated
2024/03/01
Alfa Aesar
Product number
L16715
Product name
Diethyl (bromodifluoromethyl)phosphonate, 97%
Packaging
5g
Price
$73.65
Updated
2024/03/01
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Diethyl bromodifluoromethanephosphonate Chemical Properties,Usage,Production

Uses

Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.

Uses

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 3437, 1984 DOI: 10.1021/jo00192a056

reaction suitability

reaction type: C-C Bond Formation

Diethyl bromodifluoromethanephosphonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Diethyl bromodifluoromethanephosphonate Suppliers

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View Lastest Price from Diethyl bromodifluoromethanephosphonate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
bromodifluoromethane diethyl phosphate 65094-22-6
Price
US $0.10/kg
Min. Order
0.005kg
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-15
Henan Aochuang Chemical Co.,Ltd.
Product
Diethyl bromodifluoromethanephosphonate 65094-22-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Diethyl bromodifluoromethanephosphonate 65094-22-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

65094-22-6, Diethyl bromodifluoromethanephosphonateRelated Search:

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  • Diethyl bromodifluoromethanephosphonate
  • DIETHYL (BROMODIFLUOROMETHYL)PHOSPHONATE
  • Bromodifluoromethyl diethyl phosphonate~Diethyl bromodifluoromethanephosphonate
  • BromodifluoromethylphosphonicAcidDiethylEsterDiethylBromodifluoromethylphosphonate
  • Bromodifluoromethyl diethylphosphonate 97%
  • Bromodifluoromethyldiethylphosphonate97%
  • 1-[[Bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane
  • Phosphonic acid,P-(broModifluoroMethyl)-, diethyl ester
  • (Bromodifluoromethyl)phosphonic acid diethyl ester
  • Diethyl [bromo(difluoro)methyl]phosphonate 97%
  • Diethyl bromodifluoromethanephosphonat
  • Diethyl (Bromodifluoromethyl)phosphonate &gt
  • Diethyl P-(bromodifluoromethyl)phosphonate
  • 65094-22-6
  • 65904-22-6
  • BrCF2POOC2H52
  • C5H10O3BrF2P
  • C5H10BrF2O3P
  • C-C Bond Formation
  • Horner-Wadsworth-Emmons Reagents
  • Olefination
  • Synthetic Reagents
  • C-C Bond Formation
  • Horner-Wadsworth-Emmons Reagents
  • Olefination