ChemicalBook > CAS DataBase List > Diethyl bromodifluoromethanephosphonate

Diethyl bromodifluoromethanephosphonate

Product Name: Diethyl bromodifluoromethanephosphonate
CAS No.: 65094-22-6
Chemical Name: Diethyl bromodifluoromethanephosphonate
Synonyms: DIETHYL (BROMODIFLUOROMETHYL)PHOSPHONATE;BROMODIFLUOROMETHYL DIETHYLPHOSPHONATE;BROMODIFLUOROMETHANE DIETHYL PHOSPHATE;Diethyl bromodifluoromethanephosphonat;Diethyl bromodifluoromethanephosphonate;Bromodifluoromethyldiethylphosphonate97%;Bromodifluoromethyl diethylphosphonate 97%;Diethyl P-(bromodifluoromethyl)phosphonate;Diethyl (Bromodifluoromethyl)phosphonate >Diethyl [bromo(difluoro)methyl]phosphonate 97%
CBNumber: CB8333674
Molecular Formula: C5H10BrF2O3P
Formula Weight: 267.01
MOL File: 65094-22-6.mol

Less

Diethyl bromodifluoromethanephosphonate Property

Boiling point:: 40-41 °C/0.05 mmHg (lit.)
Density: 1.503 g/mL at 25 °C (lit.)
refractive index: n20/D 1.417(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform, Ethyl Acetate
form: liquid
Specific Gravity: 1.503
color: colorless
Water Solubility: Not miscible or difficult to mix in water.
BRN: 1944045
InChI: InChI=1S/C5H10BrF2O3P/c1-3-10-12(9,11-4-2)5(6,7)8/h3-4H2,1-2H3
InChIKey: QRADKVYIJIAENZ-UHFFFAOYSA-N
SMILES: P(=O)(OCC)(OCC)C(F)(F)Br
CAS DataBase Reference: 65094-22-6(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 21/22-36/38-38-36
Safety Statements: 26-36/37/39-60-37-23
RIDADR: 3278
WGK Germany: 3
Hazard Note: Irritant
TSCA: No
HazardClass: IRRITANT, IRRITANT-HARMFUL
PackingGroup: III
HS Code: 29319090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 411361
Product name: Diethyl (bromodifluoromethyl)phosphonate
Purity: 96%
Packaging: 5g
Price: $83.68
Updated: 2025/07/31

TCI Chemical

Product number: D3071
Product name: Diethyl (Bromodifluoromethyl)phosphonate
Purity: >97.0%(GC)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: D3071
Product name: Diethyl (Bromodifluoromethyl)phosphonate
Purity: >97.0%(GC)
Packaging: 25g
Price: $149
Updated: 2025/07/31

TRC

Product number: D443845
Product name: Diethyl (Bromodifluoromethyl)phosphonate
Packaging: 5g
Price: $80
Updated: 2021/12/16

Chem-Impex

Product number: 36547
Product name: Diethyl(bromodifluoromethyl)phosphonate,≥96%(GC)
Purity: ≥96%(GC)
Packaging: 250G
Price: $384.38
Updated: 2021/12/16

Less

Diethyl bromodifluoromethanephosphonate Chemical Properties,Usage,Production

Uses

Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.

Uses

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 3437, 1984 DOI: 10.1021/jo00192a056

reaction suitability

reaction type: C-C Bond Formation

Synthesis

75-61-6

122-52-1

65094-22-6

Dibromodifluoromethane (209.8 g, 1 mol) was slowly added dropwise to a solution of triethyl phosphite (153.5 g, 0.925 mol) in anhydrous ether (450 mL) equipped with a magnetic stirrer under nitrogen protection. After the dropwise addition, the reaction system was slowly warmed to room temperature and subsequently heated to reflux for 20 hours. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure and the fraction with a boiling point of 50-52 °C (1 mmHg) was collected to afford the colorless liquid product diethyl (bromodifluoromethyl) phosphonate (256.3 g, 96% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 4.35 (m, 4H), 1.35 (m, 6H); 13C NMR (CDCl3): δ 122.9, 119.8, 118.6, 115.4, 114.2, 111.1, 66.59, 66.50, 16.56, 16.48.

References

[1] Journal of Organometallic Chemistry, 1997, vol. 529, # 1-2, p. 267 - 278
[2] Phosphorus, Sulfur and Silicon and Related Elements, 1997, vol. 122, p. 247 - 259
[3] Patent: US2004/225146, 2004, A1. Location in patent: Page 4
[4] Journal of Fluorine Chemistry, 2011, vol. 132, # 10, p. 815 - 828
[5] Patent: WO2006/78698, 2006, A1. Location in patent: Page/Page column 64-65

Diethyl bromodifluoromethanephosphonate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Diethyl bromodifluoromethanephosphonate Suppliers

Americas 1 China 186 Europe 2 France 2 Germany 3 India 5 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 33 Global 247

Cangzhou Dongen Technology Co., Ltd

Tel: 18631716282
Email: 1175897318@qq.com
Country: China
ProdList: 8
Advantage: 58

Alchemist-pharm chemical Technology Co. Ltd.

Tel: 0371-67991738 13783628208
Fax: QQ 412703949
Email: carl@alchemist-pharm.com
Country: China
ProdList: 43
Advantage: 58

Zhangjiagang Xikai Chemical Co.,Ltd

Tel: +86-0512-55701600 +86-13962289590
Fax: 0512-58538687
Email: sales@xikaichem.com
Country: China
ProdList: 308
Advantage: 58

Shanghai Kuanglin Tech LTD Co

Tel: 13701867986
Email: 13701867986@163.com
Country: China
ProdList: 100
Advantage: 58

BTC Pharmaceutical CO. Ltd

Tel: 15716293042 18862996710
Fax: 0513-68015394
Email: 15050603958@163.com
Country: China
ProdList: 694
Advantage: 55

Nanjing Qishuo Biotechnology Co., Ltd

Tel: 15556698229
Email: 314236317@qq.com
Country: China
ProdList: 225
Advantage: 58

SHANG FLUORO

Tel: 021-65170832 15601903708
Email: qinba_1@163.com
Country: China
ProdList: 399
Advantage: 60

Tianjin Propharm Co., Ltd.

Tel: 185-11025967 18511025967
Email: wubin@propharm.cn
Country: China
ProdList: 59
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

Tel: 0523-82837785 13914525028
Fax: 0523-87913272
Email: info@jszchg.com
Country: China
ProdList: 246
Advantage: 60

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Suzhou BEC Biological Technology Co., Ltd

Tel: +86-512-68095917 17712685869
Fax: +86-512-68417933
Email: sales@bek.com.cn
Country: China
ProdList: 146
Advantage: 59

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai D&B Biological Science and Technology Co.Ltd

Tel: 400-008-9730,021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3057
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2001
Advantage: 56

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Suzhou Xinkai Bio-Medical Technology Co., Ltd.

Tel: 0512-67213637 13952409868
Email: peter19zhang@163.com
Country: China
ProdList: 442
Advantage: 55

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Less

View Lastest Price from Diethyl bromodifluoromethanephosphonate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Diethyl bromodifluoromethanephosphonate 65094-22-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2025-04-01

Zibo Hangyu Biotechnology Development Co., Ltd

Product: bromodifluoromethane diethyl phosphate 65094-22-6
Price: US $0.10/kg
Min. Order: 0.005kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: Diethyl bromodifluoromethanephosphonate 65094-22-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

65094-22-6, Diethyl bromodifluoromethanephosphonateRelated Search:

Diethyl malonate Ethyl bromoacetate DIETHYL BROMOMALONATE Ethyl 2-bromopropionate Diethyl phthalate Ethyl bromodifluoroacetate 2-Hydroxyethyl methacrylate Diethyl cyanomethylphosphonate Ethyl bromofluoroacetate 1-METHYL-3-N-OCTYLIMIDAZOLIUM BROMIDE 1-Bromotetradecane 2,5-Dioxopyrrolidin-1-yl octanoate (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Bromoacetaldehyde diethyl acetal Bromo-PEG1-t-butyl ester DIETHYL PHOSPHATE METHYLPHOSPHONIC ACID Dimethyl methylphosphonate

BROMODIFLUOROMETHANE DIETHYL PHOSPHATE

BROMODIFLUOROMETHYL DIETHYLPHOSPHONATE

Diethyl bromodifluoromethanephosphonate

DIETHYL (BROMODIFLUOROMETHYL)PHOSPHONATE

Bromodifluoromethyl diethyl phosphonate~Diethyl bromodifluoromethanephosphonate

BromodifluoromethylphosphonicAcidDiethylEsterDiethylBromodifluoromethylphosphonate

Bromodifluoromethyl diethylphosphonate 97%

Bromodifluoromethyldiethylphosphonate97%

1-[[Bromo(difluoro)methyl]-ethoxyphosphoryl]oxyethane

Phosphonic acid,P-(broModifluoroMethyl)-, diethyl ester

(Bromodifluoromethyl)phosphonic acid diethyl ester

Diethyl [bromo(difluoro)methyl]phosphonate 97%

Diethyl bromodifluoromethanephosphonat

Diethyl (Bromodifluoromethyl)phosphonate &gt

Diethyl P-(bromodifluoromethyl)phosphonate

65094-22-6

65904-22-6

BrCF2POOC2H52

C5H10O3BrF2P

C5H10BrF2O3P

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination

Synthetic Reagents

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination