Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Product Name: Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
CAS No.: 153088-73-4
Chemical Name: Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
Synonyms: FHN88734;Z-D-CH2-DCB;Z-ASP-CH2-DCB;ICE INHIBITOR V;ICE INHIBITOR VI;CASPASE-1 INHIBITOR V;CASPASE-1 INHIBITOR III;Z-Asp-CH2-DCB, 10 mM in DMSO;Z-Asp-CH2-DCB, caspase inhibitor;Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE
CBNumber: CB8336473
Molecular Formula: C20H17Cl2NO7
Formula Weight: 454.26
MOL File: 153088-73-4.mol

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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Property

Boiling point:: 674.2±55.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: White to off-white powder.
pka: 4.01±0.19(Predicted)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15143
Product name: Z-Asp-CH2-DCB
Purity: ≥98%
Packaging: 5mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 15143
Product name: Z-Asp-CH2-DCB
Purity: ≥98%
Packaging: 10mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 15143
Product name: Z-Asp-CH2-DCB
Purity: ≥98%
Packaging: 25mg
Price: $228
Updated: 2024/03/01

Cayman Chemical

Product number: 15143
Product name: Z-Asp-CH2-DCB
Purity: ≥98%
Packaging: 50mg
Price: $421
Updated: 2024/03/01

TRC

Product number: A790193
Product name: Z-Asp-2,6-Dichlorobenzoyloxymethylketone
Packaging: 25mg
Price: $165
Updated: 2021/12/16

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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Chemical Properties,Usage,Production

Description

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.

Uses

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor.

References

1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Suppliers

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153088-73-4, Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONERelated Search:

AC-VDVAD-PNA Z-VAD-FMK Z-ARG-PNA HCL CASPASE INHIBITOR3 AC-VEID-AMC Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC PAC1 AC-DEVD-CHO Z-ALA-PRO-PNA Z-ALA-SER-OH Z-ALA-GLY-OH Z-ASP-GLN-MET-ASP-AFC AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC ETHYL 2,6-DICHLOROBENZOATE

ICE INHIBITOR V

ICE INHIBITOR VI

CASPASE-1 INHIBITOR V

CASPASE-1 INHIBITOR III

(BENZYLOXYCARBONYL-L-ASPART-1-YL)[(2,6-DICHLOROBENZOYL)OXY]METHANE

Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Z-D-CH2-DCB

Z-ASP-CH2-DCB

Z-L-ASP-ALPHA-[(2,6-DICHLOROBENZOYL)OXY]METHANE

N-cbz-L-aspartic acid A-(2,6-dichloro-*benzoyloxy

N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &

INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR III

N-CBZ-L-aspartic acid alpha-[(2,6-dichlorobenzoyloxy)....

Z-L-Asp α-([2,6-dichlorobenzoyloxy]methyl ketone)

CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

Benzoic acid, 2,6-dichloro-, (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester

ZAspCH2DCB,Z Asp CH2 DCB,Z-Asp-CH-2-DCB

FHN88734

(S)-3-(((Benzyloxy)carbonyl)amino)-5-((2,6-dichlorobenzoyl)oxy)-4-oxopentanoic acid

Z-Asp-CH2-DCB, caspase inhibitor

Z-Asp-CH2-DCB, 10 mM in DMSO

153088-73-4

C20H17Cl2NO7

Pepetides

peptides

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