ChemicalBook > CAS DataBase List > 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE

6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE

Product Name
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
CAS No.
55052-27-2
Chemical Name
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
Synonyms
6-CHLORO-7-AZAINDOLE;6-chloro-;o[2,3-b]pyridine;6-Chloro-7-azaindole,95%;2-Chloro-7H-pyrrolo[2,3-b]pyridine;6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 6-chloro-;6-Chloro-1H-pyrrolido [2,3-B] pyridine;6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE ISO 9001：2015 REACH
CBNumber
CB8360793
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
55052-27-2.mol
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6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE Property

Melting point:
170-175℃
Boiling point:
420.7±37.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
6.76±0.40(Predicted)
form 
Powder
color 
White to pale brown
InChI
InChI=1S/C7H5ClN2/c8-6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)
InChIKey
DSCOSIUAQUDGJM-UHFFFAOYSA-N
SMILES
C12NC=CC1=CC=C(Cl)N=2
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
RIDADR 
UN2811
HazardClass 
6.1
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B418665
Product name
6-Chloro-1H-pyrrolo[2,3-b]pyridine
Packaging
5g
Price
$150
Updated
2021/12/16
Apolloscientific
Product number
OR301275
Product name
6-Chloro-1H-pyrrolo[2,3-b]pyridine
Packaging
5g
Price
$174
Updated
2021/12/16
AK Scientific
Product number
V2201
Product name
6-Chloro-7-azaindole
Packaging
10g
Price
$181
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140689
Product name
6-Chloro-7-azaindole
Packaging
2g
Price
$100
Updated
2021/12/16
Matrix Scientific
Product number
070121
Product name
6-Chloro-1H-pyrrolo[2,3-b]pyridine
Purity
95%
Packaging
5g
Price
$140
Updated
2021/12/16
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6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production

Uses

6-Chloro-1H-pyrrolo[2,3-b]pyridine is used in the preparation of heterocyclic compounds for the use of treatment of cancer.

Synthesis

849068-50-4

55052-27-2

Example 96 Step C: Synthesis of 6-chloro-1H-pyrrolo[2,3-B]pyridine. Ethyl 6-chloro-pyrrolo[2,3-B]pyridine-1-carboxylate (400 mg, 1.78 mmol) was dissolved in methanol (35 mL), followed by the addition of 1N sodium hydroxide solution (13 mL). The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was neutralized with saturated sodium bicarbonate solution and the precipitate was collected by filtration. The precipitate was washed with water and dried by vacuum pump to afford the target product 6-chloro-1H-pyrrolo[2,3-B]pyridine (260 mg, 1.71 mmol, 96% yield). MS (electrospray positive ion mode): m/e = 153.1 ([M+H]+); LC retention time: 2.85 min.

References

[1] Patent: WO2005/28475, 2005, A2. Location in patent: Page/Page column 175
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7107 - 7112
[3] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 103-104
[4] Patent: EP2548876, 2013, A1. Location in patent: Paragraph 0438-0441
[5] Patent: WO2016/112088, 2016, A1. Location in patent: Paragraph 0447

6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

7-Azaindole 3-Chloroperoxybenzoic acid Benzyl bromide Hexamethyldisilazane

Preparation Products

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6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE Suppliers

China 198 Germany 2 India 3 United Kingdom 2 United States 11 Global 216
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE 55052-27-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-14
Dideu Industries Group Limited
Product
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE 55052-27-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-22
Career Henan Chemical Co
Product
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE 55052-27-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

55052-27-2, 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINERelated Search:

O-METHYLVALEROLACTIM 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate METHYL 6-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLATE 4-Chloro-1H-pyrrolo[2,3-β]pyridine,4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE 3-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro- 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine 4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 3-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine 6-Chloro-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one 6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro- 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate

  • 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
  • 6-CHLORO-7-AZAINDOLE
  • 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-
  • 6-chloro-
  • 2-Chloro-7H-pyrrolo[2,3-b]pyridine
  • o[2,3-b]pyridine
  • 6-Chloro-7-azaindole,95%
  • 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE ISO 9001：2015 REACH
  • 6-Chloro-1H-pyrrolido [2,3-B] pyridine
  • 55052-27-2
  • 55050-27-2
  • Pyridines