ChemicalBook > CAS DataBase List > 3-Bromo-2-chloropyridine

3-Bromo-2-chloropyridine

Product Name
3-Bromo-2-chloropyridine
CAS No.
52200-48-3
Chemical Name
3-Bromo-2-chloropyridine
Synonyms
2-CHLORO-3-BROMOPYRIDINE;3-Bromo-2-chL;TIMTEC-BB SBB003618;OTAVA-BB BB7110952626;-Bromo-2-chloropyridine;3-BROMO-2-CHLOROPYRIDINE;bromo-3 chloro-2 pyridine;3-Bromo-2-chlorolpyridine;Pyridine, 3-bromo-2-chloro-;5-Bromo-3-nitro-3-pyridinol
CBNumber
CB8375195
Molecular Formula
C5H3BrClN
Formula Weight
192.44
MOL File
52200-48-3.mol
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3-Bromo-2-chloropyridine Property

Melting point:
54-57 °C (lit.)
Boiling point:
97 °C / 10mmHg
Density 
1.7783 (rough estimate)
refractive index 
1.5400 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
pka
-0.63±0.10(Predicted)
form 
Crystalline Powder, Crystals or Flakes or Solid
color 
White to yellow
BRN 
109812
InChI
InChI=1S/C5H3BrClN/c6-4-2-1-3-8-5(4)7/h1-3H
InChIKey
HDYNIWBNWMFBDO-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC=C1Br
CAS DataBase Reference
52200-48-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
553751
Product name
3-Bromo-2-chloropyridine
Purity
98%
Packaging
5g
Price
$22.24
Updated
2025/07/31
Sigma-Aldrich
Product number
553751
Product name
3-Bromo-2-chloropyridine
Purity
98%
Packaging
25g
Price
$59.57
Updated
2025/07/31
TCI Chemical
Product number
B2328
Product name
3-Bromo-2-chloropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
B2328
Product name
3-Bromo-2-chloropyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$82
Updated
2025/07/31
TRC
Product number
B682305
Product name
3-Bromo-2-chloropyridine
Packaging
250g
Price
$725
Updated
2021/12/16
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3-Bromo-2-chloropyridine Chemical Properties,Usage,Production

Chemical Properties

yellow Long needles

Uses

3-Bromo-2-chloropyridine may be used to synthesize:

  • acetylenic dipyridone
  • 3-ethynyl-2-(phenylmethoxy)-pyridine
  • nemertelline
  • ortho-chlorodiheteroarylamine4 or 2-chloro-N-(2,3,7-trimethylbenzo[b]thien-6-yl)pyridin-3-amine

General Description

3-Bromo-2-chloropyridine can be synthesized from 3-amino-2-chloropyridine or 2-chloro-3-pyridinamine.

Synthesis

6298-19-7

52200-48-3

Example 3 Synthesis of 3-bromo-2-chloropyridine (7): water (45 mL) and 48% hydrobromic acid (27 mL) were sequentially added to a reaction vial containing 3-amino-2-chloropyridine (6) (2.57 g, 20 mmol) at room temperature. Subsequently, 2,2,6,6-tetramethylpiperidine 1-yloxy (TEMPO) (0.31 g, 2 mmol) was added to the mixed solution and the reaction system was cooled to below 10 °C. A solution of sodium nitrite (4.14 g) dissolved in water (30 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for about 2 h. After stirring, the reaction mixture was neutralized by adding a 10 mol/L aqueous sodium hydroxide solution (40 mL). The reaction mixture was extracted with toluene (300 mL in two portions) and the organic phases were combined and washed with 50 mL of water. The organic layer was concentrated under reduced pressure to remove the solvent to afford the target product 3-bromo-2-chloropyridine (7) (3.08 g, 80.1% yield).

References

[1] Patent: US2013/144061, 2013, A1. Location in patent: Paragraph 0229; 0230
[2] Journal of Organic Chemistry, 1995, vol. 60, # 5, p. 1408 - 1412

3-Bromo-2-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-2-chloropyridine Suppliers

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View Lastest Price from 3-Bromo-2-chloropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-Bromo-2-chloropyridine 52200-48-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
3-Bromo-2-chloropyridine 52200-48-3
Price
US $100.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1kg
Release date
2021-09-13
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
3-Bromo-2-chloropyridine 52200-48-3
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-15

52200-48-3, 3-Bromo-2-chloropyridineRelated Search:

3-BROMO-2-CHLORO-4-IODOPYRIDINE 5-BROMO-6-CHLOROPYRIDINE-3-CARBOXYLIC ACID 2-Chloro-3-bromo-5-methylpyridine 3-Bromo-2,6-dichloropyridine 2-Chloro-3-bromo-5-nitropyridine 3-Bromo-2-chloropyridine 3-BROMO-2-CHLOROPYRIDINE-5-SULPHONYL CHLORIDE,3-BROMO-2-CHLOROPYRIDINE-5-SULFONYL CHLORIDE,5-BROMO-6-CHLOROPYRIDINE-3-SULFONYL CHLORIDE 5-AMINO-3-BROMO-2-CHLOROPYRIDINE 3-BROMO-2-CHLORO-4-PICOLINE Methyl 3-bromo-2-chloropyridine-5-carboxylate 3-BROMO-2-CHLORO-6-PICOLINE 2,5-DIBROMO-3-CHLOROPYRIDINE 3-BROMO-2,5-DICHLOROPYRIDINE 2,3-DIBROMO-6-CHLOROPYRIDINE 4-BROMO-3-CHLOROPYRIDINE 3-BROMO-2-CHLOROPYRIDINE-4-BORONIC ACID 2-AMINO-3-BROMO-5-CHLOROPYRIDINE 3,5-Dibromo-2-chloropyridine

  • 3-Bromo-2-chlorolpyridine
  • 3-BROMO-2-CHLOROPYRIDINE 98+%
  • bromo-3 chloro-2 pyridine
  • 3-broMo -2-chlorine pyridine
  • 2 - chloro - 3 - broMide pyridine
  • 3-Bromo-2-chloropyridine 98%
  • OTAVA-BB BB7110952626
  • 2-CHLORO-3-BROMOPYRIDINE
  • TIMTEC-BB SBB003618
  • 3-BROMO-2-CHLOROPYRIDINE
  • 3-Bromo-2-chloropyridine &gt
  • 3-Bromo-2-chL
  • Pyridine, 3-bromo-2-chloro-
  • 5-Bromo-3-nitro-3-pyridinol
  • 3-Bromo-2-chloropyridine ISO 9001：2015 REACH
  • 52200-48-3 ISO 9001：2015 REACH
  • -Bromo-2-chloropyridine
  • 3-Bromo-2-chloropyridine, 95%
  • 52200-48-3
  • C5H3ClBrN
  • Halopyridines
  • Bromopyridines
  • Chloropyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Building Blocks
  • compounds of pyridine
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Variety of halogenated heterocyclic series
  • Bromopyridines
  • Chloropyridines
  • Halopyridines
  • Boronic Acid
  • blocks
  • Bromides
  • Pyridines
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Pyridine series
  • alkyl chloride| alkyl bromide
  • bc0001