ChemicalBook > CAS DataBase List > Boc-5-aminopentanoic acid

Boc-5-aminopentanoic acid

Product Name: Boc-5-aminopentanoic acid
CAS No.: 27219-07-4
Chemical Name: Boc-5-aminopentanoic acid
Synonyms: BOC-5-AVA-OH;BOC-5-AMINOVALERIC ACID;5-(TERT-BUTOXYCARBONYLAMINO)VALERIC ACID;BOC-APE(5)-OH;Boc-5-Ava-OH 97%;BOC-NH-(CH2)4-COOH;RARECHEM EM WB 0073;Boc-d-aMinovaleric acid;5-(BOC-AMINO)VALERIC ACID;N-BOC-5-AMINOVALERIC ACID
CBNumber: CB8379946
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 27219-07-4.mol

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Boc-5-aminopentanoic acid Property

Melting point:: 48-52 °C(lit.)
Boiling point:: 160-168 °C0.8 mm Hg(lit.)
Density: 1.1518 (rough estimate)
refractive index: 1.4500 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Powder
pka: 4.72±0.10(Predicted)
color: Off-white
BRN: 2048862
CAS DataBase Reference: 27219-07-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HazardClass: IRRITANT
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 475351
Product name: Boc-5-Ava-OH
Purity: 97%
Packaging: 5g
Price: $166
Updated: 2023/06/20

Sigma-Aldrich

Product number: 475351
Product name: Boc-5-Ava-OH
Purity: 97%
Packaging: 25g
Price: $658
Updated: 2023/06/20

TCI Chemical

Product number: B2895
Product name: N-(tert-Butoxycarbonyl)-5-aminovaleric Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $89
Updated: 2025/07/31

TCI Chemical

Product number: B2895
Product name: N-(tert-Butoxycarbonyl)-5-aminovaleric Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $301
Updated: 2025/07/31

TRC

Product number: B621205
Product name: Boc-5-aminovalericAcid
Packaging: 25g
Price: $360
Updated: 2021/12/16

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Boc-5-aminopentanoic acid Chemical Properties,Usage,Production

Description

Boc-5-aminopentanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Boc-5-aminopentanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

solid

Uses

Boc-5-aminovaleric acid can be used to synthesize inhibitors of bacterial quorum seining and biofilm formation. It can also be used to synthesize diblock and triblock copolymers.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 2424, 1983 DOI: 10.1021/jo00162a028

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

660-88-8

27219-07-4

Example 4: To a mixed solution of 100 mL of 2% aqueous sodium hydroxide and 100 mL of dioxane containing 5-aminopentanoic acid (5.85 g, 0.05 mol), a solution of dioxane containing di-tert-butyl dicarbonate (10.9 g, 0.05 mol) was slowly added dropwise. The reaction mixture was stirred at room temperature for 18 h and then acidified with 1 N hydrochloric acid to pH 3. The acidified reaction mixture was extracted three times with dichloromethane. The organic layers were combined, washed sequentially with water and dried over sodium sulfate, and concentrated under reduced pressure to give 10.1 g (93.5% yield) of 5-(tert-butoxycarbonylamino)pentanoic acid as a white crystalline solid.

References

[1] Journal of the American Chemical Society, 2018, vol. 140, # 44, p. 14599 - 14603
[2] ChemMedChem, 2016, p. 1172 - 1187
[3] ChemMedChem, 2016, vol. 11, # 11, p. 1172 - 1187
[4] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 4, p. 402 - 407
[5] Patent: US4476228, 1984, A

Boc-5-aminopentanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-5-aminopentanoic acid manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Boc-5-aminopentanoic acid 27219-07-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 1000kg
Release date: 2025-10-23

Career Henan Chemical Co

Product: Boc-5-aminopentanoic acid 27219-07-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-07

27219-07-4, Boc-5-aminopentanoic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Folic acid Glycine ALTRENOGEST 5-AMINOVALERIC ACID MAGNESIUM DIPROPYLACETATE HYDRATE Estradiol valerate 2-Propylpentanoic acid Pivalic acid N-Carbobenzyloxyglycine 1-(Boc-amino)cyclopropanecarboxylic acid BOC-HYP(BZL)-OH BOC-L-2-AMINOADIPIC ACID Boc-Hyp-OH (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-L-Proline N-Boc-trans-4-Hydroxy-L-proline methyl ester Fmoc-Orn(Boc)-OH

N-T-BUTOXYCARBONYL-5-AMINOPENTANOIC ACID

N-DELTA-T-BUTOXYCARBONYL-DELTA-AMINOVALERIC ACID

N-BOC-5-AMINOPENTANOIC ACID

N-BOC-5-AMINOVALERIC ACID

PENTANOIC ACID, 5-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-

RARECHEM EM WB 0073

5-(TERT-BUTOXYCARBONYLAMINO)VALERIC ACID

5-(TERT-BUTOXYCARBONYLAMINO)PENTANOIC ACID

5-(BOC-AMINO)PENTANOIC ACID

5-(BOC-AMINO)VALERIC ACID

5-[(tert-Butyloxycarbonyl)amino]pentanoic acid

5-[[(1,1-Dimethylethyl)oxy]carbonyl]aminopentanoic acid

BOC-NH-(CH2)4-COOH

BOC-APE(5)-OH

BOC-5-AMINOVALERIC ACID

BOC-5-AVA-OH

BOC-5-AMINOPENTANOIC ACID

BOC-DELTA-AMINOVALERIC ACID

Boc-5-AMinovaleric acid Boc-5-AMinovaleric acid

5-(Boc-amino)pentanoic acid, 5-(Boc-amino)valeric acid

5-(tert-Butoxycarbonylamino)pentanoic Acid N-Boc-5-aminovaleric Acid N-Boc-5-aminopentanoic Acid

Boc-d-aMinovaleric acid

N-(tert-Butoxycarbonyl)-5-aMinovaleric Acid

Boc-5-Ava-OH 97%

Boc-2-amino-5-phenylpentanoic acid DCHA

<i>N</i>-(<i>tert</i>-Butoxycarbonyl)-5-aminovaleric Acid

Boc-5-aminovaleric acid≥ 97% (HPLC)

5-(Boc-amino)valeric AcidN-Boc-5-aminovaleric Acid

N-(tert-Butoxycarbonyl)-5-aminop

(Tert-Butoxy)Carbonyl 5-Ava-OH

N-(tert-Butoxycarbonyl)-5-aminovaleric Acid &gt

5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid

5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoicaci

N-(tert-Butoxycarbonyl)-5-aminopentanoic Acid

Boc-5-aminopentanoic acid USP/EP/BP

tert-butyl 1-phenyl-2,9,12,15-tetraoxaheptadecan-17-oate

5-[[(1,1-Dimethylethoxy)carbonyl]amino]pentanoic acid

PROTAC Linkers,Inhibitor,protac,Boc NH C4 acid,inhibit,BocNHC4acid,Boc-NH-C-4-acid,linker

5-(N-BOC-Amino)pentanoic acid

27219-07-4

CH33CO2CNHCH24CO2H

CARBOXYLIC ACID

Unnatural Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Linear Core Amino Acids