Sodium bis(trimethylsilyl)amide

Product Name: Sodium bis(trimethylsilyl)amide
CAS No.: 1070-89-9
Chemical Name: Sodium bis(trimethylsilyl)amide
Synonyms: NAHMDS;SODIUM HEXAMETHYLDISILAZANE;SODIUM HEXAMETHYLDISILAZIDE;Sodium Bis(trimethylsilyl)amide, 1M THF;HMDS Na;N-SODIOHEXAMETHYLDISILAZANE;Sodiobis(trimethylsilyl)amine;sodium bis(trimethylsilyl)amide solution;HMN NA SALT;sodiumbis(tri
CBNumber: CB8382263
Molecular Formula: C6H18NNaSi2
Formula Weight: 183.37
MOL File: 1070-89-9.mol

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Sodium bis(trimethylsilyl)amide Property

Melting point:: 171-175 °C (lit.)
Boiling point:: 67°C
Density: 0.904 g/mL at 25 °C
Flash point:: 43 °F
storage temp.: 2-8°C
solubility: Soluble in hexane, toluene, ether,terahydrofuran, benzene and toluene.
form: Liquid
Specific Gravity: 0.9
color: Clear orange to brown
Water Solubility: reacts
Sensitive: Moisture Sensitive
Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents
BRN: 3629917
Exposure limits: ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
CAS DataBase Reference: 1070-89-9(CAS DataBase Reference)
EPA Substance Registry System: Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1070-89-9)

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Safety

Hazard Codes: C,F
Risk Statements: 14-34-19-11-67-65-63-48/20-14/15-40-37
Safety Statements: 26-45-62-36/37/39-33-16-43-8
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
F: 10-21
TSCA: Yes
HazardClass: 4.3
PackingGroup: III
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 245585
Product name: Sodium bis(trimethylsilyl)amide solution
Purity: 1.0?M in THF
Packaging: 100ML
Price: $62
Updated: 2024/03/01

Sigma-Aldrich

Product number: 80631
Product name: Sodium bis(trimethylsilyl)amide solution
Purity: produced by Wacker Chemie AG, Burghausen, Germany, 40% in THF
Packaging: 500mL
Price: $200
Updated: 2024/03/01

Sigma-Aldrich

Product number: 245585
Product name: Sodium bis(trimethylsilyl)amide solution
Purity: 1.0?M in THF
Packaging: 800ML
Price: $287
Updated: 2024/03/01

Sigma-Aldrich

Product number: 235083
Product name: Sodium bis(trimethylsilyl)amide
Purity: 95%
Packaging: 5g
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: 235083
Product name: Sodium bis(trimethylsilyl)amide
Purity: 95%
Packaging: 25g
Price: $115
Updated: 2023/06/20

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Sodium bis(trimethylsilyl)amide Chemical Properties,Usage,Production

Chemical Properties

Slightly yellow to light beige crystalline powder

Physical properties

mp 171–175 °C; bp 170 °C/2 mmHg.

Uses

It is a strong base; deprotonates ketones and esters to generate enolate derivative.

Uses

Sodium bis(trimethylsilyl)amide is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, it has been used as a nitrogen source for the preparation of primary amines.It is useful as a sterically hindered base and as a nucleophile.

Uses

Significantly accelerated the polymerization of pheneylacetylene in conjunction with rhodium (I) catalysis

General Description

Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.

Purification Methods

It can be sublimed at 170o/2mm (bath temperature 220-250o) onto a cold finger, and can be recrystallised from *C6H6 (its solubility is: 10g in 100mL at 60o). It is slightly soluble in Et2O and is decomposed by H2O. [Wannagat & Niederprüm Chem Ber 94 1540 1961.]It is available commercially under N2 in Sure/Seal bottles in tetrahydrofuran (various concentrations) and at ~0.6M in toluene. [Beilstein 4 IV 4014.]

Sodium bis(trimethylsilyl)amide Preparation Products And Raw materials

Raw materials

Toluene Sodium Tetrahydrofuran Hexamethyldisilazane

Preparation Products

TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE

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Sodium bis(trimethylsilyl)amide Suppliers

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View Lastest Price from Sodium bis(trimethylsilyl)amide manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Sodium bis(trimethylsilyl)amide 1070-89-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-11-29

Hebei Yanxi Chemical Co., Ltd.

Product: Sodium bis(trimethylsilyl)amide 1070-89-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-29

hebei hongtan Biotechnology Co., Ltd

Product: Sodium bis(trimethylsilyl)amide 1070-89-9
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-03-25

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