THYROGLOBULIN, HUMAN
Description Source Background- Product Name
- THYROGLOBULIN, HUMAN
- CAS No.
- 9010-34-8
- Chemical Name
- THYROGLOBULIN, HUMAN
- Synonyms
- proloid;Elityran;Thyractin;TG, HUMAN;HSDB 3190;THYROGLOBULIN;thyroglobulins;thyroidglobulin;Globulins, thyro;TG, HUMAN THYROID
- CBNumber
- CB8390318
- Formula Weight
- 0
- MOL File
- Mol file
THYROGLOBULIN, HUMAN Property
- storage temp.
- -20°C
- solubility
- H2O: 20 mg/mL
- form
- powder
- color
- white to tan
- biological source
- human thyroid
- Water Solubility
- H2O: 20mg/mL, hazy, yellow
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- F
- 8-10-21
- HS Code
- 3504009000
- Hazardous Substances Data
- 9010-34-8(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- T9145
- Product name
- Thyroglobulin from bovine thyroid
- Purity
- (For Gel Filtration Chromatography)
- Packaging
- 1vial
- Price
- $91.29
- Updated
- 2025/07/31
- Product number
- T-113
- Product name
- Thyroglobulin solution
- Purity
- 10?μg/mL (SigMatrix Serum Diluent), certified reference material, ampule of 1?mL, Cerilliant?
- Packaging
- 1mL
- Price
- $437
- Updated
- 2025/07/31
- Product number
- 609312
- Product name
- Thyroglobulin, Human Thyroid
- Packaging
- 1mg
- Price
- $155
- Updated
- 2025/07/31
- Product number
- 609310
- Product name
- Thyroglobulin, Bovine Thyroid Gland
- Packaging
- 100mg
- Price
- $229
- Updated
- 2025/07/31
- Product number
- T6830
- Product name
- Thyroglobulin human
- Purity
- ≥95% (SDS-PAGE)
- Packaging
- 1mg
- Price
- $242
- Updated
- 2025/07/31
THYROGLOBULIN, HUMAN Chemical Properties,Usage,Production
Description
Thyroglobulin is of special importance, because it serves as the matrix for the synthesis of T4 and T3 and
as the storage form of the hormones and iodide. Thyroglobulin, a large glycoprotein with a molecular weight
of 660,000 Da, accounts for about one-third of the weight of the thyroid gland. Thyroglobulin carries an
average of 6 tyrosyl residues as monoiodo-L-tyrosine, 5 residues as diiodo-L-tyrosine, 0.3 residues as T3,
and 1 residue as T4. From these values, it can be estimated that a 20 g thyroid stores roughly 10 μmol
(7.8 mg) of T4 and 3 μmol (2.0 mg) of T3 and that the normal human thyroid gland contains enough potential
T4 to maintain a euthyroid state for 2 months without new synthesis.
The synthesis of the thyroid hormones, T3 and T4, is regulated by thyrotropin (thyroid-stimulating hormone
[TSH]), which stimulates the synthesis of thyroglobulin, thyroperoxidase (TPO), and hydrogen peroxide. The
formation of the thyroid hormones depends on an exogenous supply of iodide. The thyroid gland is unique in
that it is the only tissue of the body able to accumulate iodine in large quantities and incorporate it into
hormones. Approximately 25% of the body's supply of iodide is located in the thyroid gland. The iodine
atoms play a unique role in the conformational preferences for T3 and T4 because of their large steric
bulkiness. The metabolism of iodine is so closely related to thyroid function that the two must be considered
together. The formation of thyroid hormones involves the following complex sequence of events: 1) active
uptake of iodide by the follicular cells, 2) oxidation of iodide and formation of iodotyrosyl residues of
thyroglobulin, 3) formation of iodothyronines from iodotyrosines, 4) proteolysis of thyroglobulin and release
of T4 and T3 into blood, and 5) conversion of T4 to T3.
Uses
Proloid (Parke-Davis).
Uses
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Biological Functions
Thyroid hormones regulate the turnover of carbohydrates, lipids, and proteins. They promote glucose absorption, hepatic and renal gluconeogenesis, hepatic glycogenolysis, and glucose utilization in muscle and adipose tissue. They increase de novo cholesterol synthesis but increase low-density lipoprotein degradation and cholesterol disposal even more, leading to a net decrease in total and in low-density lipoprotein cholesterol plasma levels. Thyroid hormones are anabolic when present at normal concentrations; they then stimulate the expression of many key enzymes of metabolism.
General Description
Thyroglobulin, a glycoprotein, is composed of several peptidechains; it also contains 0.5% to 1% iodine and 8% to10% carbohydrate in the form of two types of polysaccharide.The formation of thyroglobulin is regulated by TSH.Thyroglobulin has no hormonal properties. It must be hydrolyzedto release the hormonal iodothyronines thyroxineand liothyronine.
Biochem/physiol Actions
Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.
Mechanism of action
The two most important actions of thyroid hormone are those related to oxygen consumption and those related to protein synthesis. Most effects of thyroid hormones can be related to the activation of genes following the binding of the hormone to high-affinity receptors of cell nuclei, but direct interactions of thyroid hormones with other cellular receptors cannot be excluded.
Description
Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 660 kDa (330 kDa per subunit).
Source
Mammalian cell line
Background
Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.
Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.
THYROGLOBULIN, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from THYROGLOBULIN, HUMAN manufacturers
- Product
- Thyroglobulin froM bovine thyroid 9010-34-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-06