2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Product Name: 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
CAS No.: 33252-64-1
Chemical Name: 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
Synonyms: 5-NITRO-3-(TRIFLUOROMETHYL)PYRIDIN-2-OL;3-NITRO-5-(TRIFLUOROMETHYL)PYRIDIN-2-OL;BUTTPARK 25\01-34;2-hydroxy-3-nitro-5-trifluoropyridine;5-NITRO-3-(TRIFLUOROMETHYL-2-PYRIDONE);3-NITRO-5-(TRIFLUOROMETHYL)-2-PYRIDONE;3-Nitro-5-(trifluoroMethyl)pyridin-2-o;3-NITRO-5-TRIFLUOROMETHYL-2-PYRIDINONE;5-(trifluoromethyl)-3-nitropyridin-2-ol;3-Nitro-5-(trifluoromethyl)-2-pyridinol
CBNumber: CB8395090
Molecular Formula: C6H3F3N2O3
Formula Weight: 208.09
MOL File: 33252-64-1.mol

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2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Property

Melting point:: 189 °C
Boiling point:: 276.2±40.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 5.89±0.10(Predicted)
form: Solid
color: Off-white
InChI: InChI=1S/C6H3F3N2O3/c7-6(8,9)3-1-4(11(13)14)5(12)10-2-3/h1-2H,(H,10,12)
InChIKey: JYXKHKBZLLIWEV-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(C(F)(F)F)C=C1[N+]([O-])=O
CAS DataBase Reference: 33252-64-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
RIDADR: NA3077
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: N900918
Product name: 3-Nitro-5-(trifluoromethyl)pyridin-2(1H)-one
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC4861
Product name: 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $17
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-3-23
Product name: 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $28
Updated: 2021/12/16

Matrix Scientific

Product number: 001464
Product name: 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 5g
Price: $62
Updated: 2021/12/16

AK Scientific

Product number: J50583
Product name: 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
Packaging: 5g
Price: $62
Updated: 2021/12/16

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2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

Synthesis

33252-63-0

33252-64-1

The general procedure for the synthesis of 2-hydroxy-3-nitro-5-trifluoromethylpyridine using 2-hydroxy-5-trifluoromethylpyridine as starting material was as follows: 2-hydroxy-5-trifluoromethylpyridine (10.0 g, 61.3 mmol) was dissolved in concentrated sulfuric acid (50 mL), and the reaction system was cooled to 0 °C. Fuming nitric acid (14 mL, 92 mmol) was slowly added dropwise at 0 °C. After the dropwise addition, the reaction was kept at 0 °C and continued to be stirred for 1 h. Subsequently, the temperature of the reaction was raised to 65 °C and the reaction was continued to be stirred for 24 h. The reaction temperature was increased to 65 °C and the reaction was continued to be stirred. After completion of the reaction, the reaction system was cooled to room temperature and the reaction was quenched by slowly pouring into ice (300 g). Subsequently, 50% aqueous sodium hydroxide solution (85 mL) was slowly added to neutralize the reaction mixture. The aqueous phase was extracted several times with ethyl acetate (4 x 200 mL), all organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a yellow solid 2-hydroxy-3-nitro-5-trifluoromethylpyridine 7.4 g in 58% yield. The product was characterized by 1H NMR (CDCl3): δ 8.66 (s, 1H), 8.29 (s, 1H).

References

[1] Patent: WO2009/7418, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: CN105111209, 2017, B. Location in patent: Paragraph 0029; 0036
[3] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 14; 35
[4] Patent: WO2011/43404, 2011, A1. Location in patent: Page/Page column 111-112
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3983 - 3987

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Suppliers

Belgium 1 China 145 France 2 Germany 3 India 6 Italy 1 United Kingdom 9 United States 18 Global 185

Alchem Pharmtech,Inc.

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View Lastest Price from 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Nitro-5-(trifluoromethyl)-2-pyridinol 33252-64-1
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Shaanxi Dideu Medichem Co. Ltd

Product: 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-04

PNP Biotech Co. Ltd

Product: 3-Nitro-5-(trifluoromethyl)-2-pyridinol 33252-64-1
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-14

33252-64-1, 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINERelated Search:

2-(4-BROMOPHENYL)PROPAN-2-OL 5-AMINOMETHYL-1H-PYRIDIN-2-ONE 2-HYDROXY-3-PHENYLPYRIDINE 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE 3-BroMo-6-chloropyridin-2-ol 2-HYDROXY-5-METHYLPYRAZINE 6-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE 2-HYDROXY-5-IODO-BENZONITRILE 3-Cyano-2-hydroxy-5-iodopyridine 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE,2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine 98%,2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine98% 5-Trifluoromethyl-pyridin-3-ylamine 3-METHYL-5-NITROPYRIDINE 2-Hydroxy-5-methyl-3-nitropyridine 2-HYDROXY-3-NITROPYRIDINE 5-Methylpyridin-3-amine 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 2-HYDROXY-3-AMINO-5-PICOLINE

3-NITRO-5-(TRIFLUOROMETHYL)PYRIDIN-2-OL

3-NITRO-5-(TRIFLUOROMETHYL)-2-PYRIDONE

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

2-HYDROXY-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE

5-NITRO-3-(TRIFLUOROMETHYL-2-PYRIDONE)

5-NITRO-3-(TRIFLUOROMETHYL)PYRIDIN-2-OL

3-Nitro-5-(trifluoromethyl)pyridin-2-one

2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine 98%

2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine98%

5-(trifluoromethyl)-3-nitropyridin-2-ol

2(1H)-Pyridinone,3-nitro-5-(trifluoromethyl)-

2-hydroxy-3-nitro-5-trifluoropyridine

3-Nitro-5-(trifluoroMethyl)pyridin-2-o

3-NITRO-5-TRIFLUOROMETHYL-2-PYRIDINONE

3-Nitro-5-trifluoroMethyl-1H-pyridin-2-one

3-Nitro-5-(trifluoromethyl)pyridin-2-ol, 3-Nitro-5-(trifluoromethyl)pyridin-2(1H)-one, 6-Hydroxy-5-nitro-alpha,alpha,alpha-trifluoro-3-picoline

3-Nitro-5-(trifluoromethyl)pyridin-2-ol, 3-Nitro-5-(trifluoromethyl)pyridin-2(1H)-one

BUTTPARK 25\01-34

3-Nitro-5-(trifluoromethyl)-2-pyridinol

33252-64-1

Pyridines

Pyridine