ChemicalBook > CAS DataBase List > EC 1.1.1.42

EC 1.1.1.42

Description Source Background

Product Name: EC 1.1.1.42
CAS No.: 9028-48-2
Chemical Name: EC 1.1.1.42
Synonyms: IDH;ICDH;IDH1;IDHM;IDPM;IDCD;PICD;ICD-M;D2HGA2;HEL-216
CBNumber: CB8395171
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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EC 1.1.1.42 Property

storage temp.: 2-8°C
form: solution (clear)
color: yellow-brown
biological source: Porcine heart
Specific Activity: 3-20units/mg protein

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Safety

WGK Germany: 3
F: 10
HS Code: 3507909090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I5036
Product name: Isocitrate Dehydrogenase 1 (NADP+) human
Purity: recombinant, expressed in E. coli, lyophilized powder, ≥80?units/mg protein
Packaging: 100μg
Price: $506.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: I2411
Product name: Isocitrate Dehydrogenase 1 (NADP+) human
Purity: recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)
Packaging: 10μg
Price: $740
Updated: 2025/07/31

Sigma-Aldrich

Product number: I1877
Product name: Isocitric Dehydrogenase (NADP) from porcine heart
Purity: Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
Packaging: 500mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: I1877
Product name: Isocitric Dehydrogenase (NADP) from porcine heart
Purity: Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
Packaging: 1g
Price: $403.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: I2002
Product name: Isocitric Dehydrogenase (NADP) from porcine heart
Purity: Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
Packaging: 25mg
Price: $122
Updated: 2025/07/31

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EC 1.1.1.42 Chemical Properties,Usage,Production

Uses

Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer .

General Description

Isocitrate dehydrogenase 1 (IDH1) gene is located on human chromosome 2q33. IDH1 is present in the cytoplasm and peroxisomes. It is expressed at high levels in the mammalian liver. IDH1 consists of a C-terminal tripeptide peroxisome, that targets the signal one sequence.

Biochem/physiol Actions

Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production.

Description

Recombinant Saccharomyces Cerevisiae ICDH (NADP) derived from yeast host cells by using over-expression system, is full length same as designated ICD1 from Saccharomyces Cerevisiae. The N-terminal amino acid Phenylalanine residue next to Met is substituted with Alanine for overexpression.
The ICDH is purified by proprietary chromatographic techniques.

Source

Yeast cells

Background

Isocitrate Dehydrogenase is an enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle.

EC 1.1.1.42 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from EC 1.1.1.42 manufacturers

Career Henan Chemical Co

Product: EC 1.1.1.42 9028-48-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

9028-48-2, EC 1.1.1.42Related Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE Ethyl isocyanoacetate Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) SALCOMINE COBALT(II) ACETYLACETONATE PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE Tris(2,4-pentanedionato)chroMiuM(III) TERT-BUTYL ISOCYANIDE Aluminum acetylacetonate Benzyl isocyanide Cupric acetylacetonate

THREO-DS-ISOCITRATE: NADP+ OXIDOREDUCTASE

THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING]

THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE I

THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE IV

isocitrate dehydrogenase from porcine heart

ICDH

ISOCITRIC DEHYDROGENASE (NADP)

ISOCITRIC DEHYDROGENASE (NADP) TYPE I

ISOCITRIC DEHYDROGENASE (NADP) TYPE IV

ISOCITRATE DEHYDROGENASE

EC 1.1.1.42

EC 1.1.1.42 TYPE I

EC 1.1.1.42 TYPE IV

ISOCITRAT DEHYDROGENASE FROM PORCINE HEA RT, 3-8 U/MG

ISOCITRIC DEHYDROGENASE TYPE IV FROM*POR CINE HEART

ISOCITRATE DEHYDROGENASE FROM PORCINE HE ART, ~10 U/MG

ISOCITRIC DEHYDROGENASE TYPE I CRUDE*FRO M PORCINE H

isocitric dehydrogenase (nadp) from porcine heart

Recombinant Isocitrate Dehydrogenase

isocitric dehydrogenase

ICDH, threo-Ds-Isocitrate: NADP+ oxidoreductase

Isocitric Dehydrogenase (NADP) from porcine heart,threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH

Isocitrate dehydrogenase (NAD+) recombinant from Yeast, 50% glycerol solution

rICDH (NADP), threo-Ds-Isocitrate: NAD oxidoreductase (decarboxylating)

rICDH (NAD), threo-Ds-Isocitrate: NAD oxidoreductase (decarboxylating)

IsoCltrate dehydrogenase

TPN-specific isocitrate dehydrogenase

TPN-linked isocitrate dehydrogenase

TPN-isocitrate dehydrogenase

TPN-dependent isocitrate dehydrogenase

Oxalosuccinic decarboxylase

Isocitrate Dehydrogenase preparation porcine heart

isocitric dehydrogenase type I crude*from porcine

Dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate)

ISOCITRIC DEHYDROGENASE HIGHLY PURIFIED FROM PORCIN

Isocitrate Dehydrogenase 1 (NADP+) huMan

IDH

IDH1

Isocitrate Dehydrogenase Cytoplasmic

MGC171441

MGC174090

MGC55806

Isocitric Dehydrogenase (NADP), Bacillus subtilis, recombinant from E. coli

NADP-specific isocitric dehydyrogenase

NADPH-dependent isocitrate dehydrogenase

Isocitrate Dehydrogenase (NADP+) from Bacteria, Recombinant

Native Porcine Isocitric Dehydrogenase (NADP)

Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant

Recombinant Human IDH1 C-his8 Protein, His Tag

Recombinant Human IDH1 Protein, His Tag

Isocitrate dehydrogenase from Bacillus subtilis, Recombinant

:THREO-DS-ISOCITRATE

Isocitrate dehydrogenas

Isocitric Dehydrogenase (NADP) from porcine heart Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein

Isocitrate Dehydrogenase Activity Microplate Assay Kit

Recombinant Human IDH1 Protein (R132H, C-8His)

IDHM

IDPM