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Valacyclovir hydrochloride

Product Name
Valacyclovir hydrochloride
CAS No.
124832-27-5
Chemical Name
Valacyclovir hydrochloride
Synonyms
VALACYCLOVIR;VALACICLOVIR HCL;VALACICLOVIR HYDROCHLORIDE;Valtrex;Valacyclovir hydrochloride hydrate;256U;VALACV;BW 256;Zelitrex;BW 256U87
CBNumber
CB8430566
Molecular Formula
C13H20N6O4.ClH
Formula Weight
360.8
MOL File
124832-27-5.mol
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Valacyclovir hydrochloride Property

Melting point:
170-172°C
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
H2O: >20mg/mL
form 
solid
color 
white
Water Solubility 
H2O: >20mg/mL
λmax
253nm(H2O)(lit.)
Merck 
14,9899
Stability:
Hygroscopic
CAS DataBase Reference
124832-27-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-24/25
RIDADR 
3077
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1601
Product name
Valacyclovir HCl
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1707839
Product name
Valacyclovir hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
V0111
Product name
Valacyclovir Hydrochloride Hydrate
Purity
>97.0%(HPLC)(N)
Packaging
100mg
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
V0111
Product name
Valacyclovir Hydrochloride Hydrate
Purity
>97.0%(HPLC)(N)
Packaging
1g
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
23801
Product name
L-Valacyclovir (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$37
Updated
2024/03/01
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Valacyclovir hydrochloride Chemical Properties,Usage,Production

Description

Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.

Chemical Properties

White Crystalline Powder

Originator

Glaxo Wellcome (United Kingdom)

Uses

Acyclovir (A192400) impurity. The L-Valine ester prodrug of Acyclovir.

Uses

Valaciclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.

Definition

ChEBI: Valacyclovir hydrochloride is an organic molecular entity.

brand name

Valtrex (GlaxoSmithKline).

General Description

Valacyclovir (Valtrex) is the hydrochloride salt of the Lvalylester of acyclovir. The compound is a water-solublecrystalline solid, and it is a prodrug intended to increase thebioavailability of acyclovir by increasing lipophilicity.Valacyclovir is hydrolyzed rapidly and almost completely toacyclovir following oral administration.
Valacyclovir has been approved for the treatment of herpeszoster (shingles) in immunocompromised patients. Theside effect profile observed in valacyclovir is comparablewith bioequivalent doses of acyclovir.

Pharmacokinetics

The binding of valacyclovir to human plasma proteins ranges between 13.5 to 17.9%. The plasma elimination half-life of acyclovir is 2.5 to 3.3 hours. The bioavailability of valacyclovir hydrochloride is 54%, compared to approximately 20% for oral acyclovir, and it is as effective as acyclovir in decreasing the duration of pain associated with posttherapeutic neuralgia and episodes of genital lesion healing.

Side effects

The adverse effects are similar to acyclovir, which include nausea, headache, vomiting, constipation, and anorexia.

Valacyclovir hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Valacyclovir hydrochloride Suppliers

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View Lastest Price from Valacyclovir hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Valacyclovir HCl 124832-27-5
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06
shandong perfect biotechnology co.ltd
Product
Valacyclovir hydrochloride 124832-27-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
1000kg
Release date
2023-11-16
Zibo Wei Bin Import & Export Trade Co. Ltd.
Product
Valacyclovir Hydrochloride 124832-27-5
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1t
Release date
2023-07-11

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