(TRIMETHYLSILYL)ACETIC ACID Property

Melting point:

39-42 °C(lit.)

Boiling point:

90-95°C 10mm

Density 

0.8830 (estimate)

Flash point:

203 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Sol ethereal solvents.

form 

solid

pka

5.23±0.10(Predicted)

Hydrolytic Sensitivity

4: no reaction with water under neutral conditions

Sensitive 

Moisture Sensitive

BRN 

1679394

CAS DataBase Reference

2345-38-2(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, (trimethylsilyl)-(2345-38-2)

EPA Substance Registry System

Acetic acid, (trimethylsilyl)- (2345-38-2)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN3261

WGK Germany 

2

RTECS 

AK0843500

F 

3-10-21

TSCA 

No

HazardClass 

8

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(TRIMETHYLSILYL)ACETIC ACID Chemical Properties,Usage,Production

Physical properties

mp 40 °C.

Uses

(Trimethylsilyl)acetic acid may be used in chemical synthesis.

Uses

Trimethylsilylacetic Acid is a valuable reagent used in preparation of α,β-unsaturated carboxylic acids and α-trimethylsilylbutyrolactones,

Preparation

Obtained from the reaction of trimethylsilylmethylmagnesium chloride with carbon dioxide;3 can also be prepared by reaction of acetic acid with 2 equiv of lithium diisopropylamide, followed by chlorotrimethylsilane and hydrolysis.