ChemicalBook > CAS DataBase List > 5-Chloropyridine-2-carboxylic acid
5-Chloropyridine-2-carboxylic acid
- Product Name
- 5-Chloropyridine-2-carboxylic acid
- CAS No.
- 86873-60-1
- Chemical Name
- 5-Chloropyridine-2-carboxylic acid
- Synonyms
- 5-CHLOROPICOLINIC ACID;5-CHLORO-2-PICOLINIC ACID;5-chloro-2-picolinic cacid;5-Chloro-2-pyridinecarboxylic;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID;5-CHLORO-2-PYRIDINECARBOXYLIC ACID;5-Chloro-pyridin-2-carboxylic acid;5-CHLORO-2-PYDRIDINECARBOXYLIC ACID;5-Chloropyridine-2-carboxylicacid98%;2-Pyridinecarboxylic acid, 5-chloro-
- CBNumber
- CB8490054
- Molecular Formula
- C6H4ClNO2
- Formula Weight
- 157.55
- MOL File
- 86873-60-1.mol
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5-Chloropyridine-2-carboxylic acid Property
- Melting point:
- 166-171℃
- Boiling point:
- 310.3±22.0 °C(Predicted)
- Density
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.41±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H4ClNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)
- InChIKey
- GJLOKYIYZIOIPN-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(Cl)C=C1
- CAS DataBase Reference
- 86873-60-1(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-40-22
- Safety Statements
- 22-36
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- C2736
- Product name
- 5-Chloro-2-pyridinecarboxylic Acid
- Packaging
- 1G
- Price
- $20
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C2736
- Product name
- 5-Chloro-2-pyridinecarboxylic Acid
- Packaging
- 5G
- Price
- $78
- Updated
- 2025/07/31
TRC
- Product number
- C369840
- Product name
- 5-ChloropicolinicAcid
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC13136
- Product name
- 5-Chloro-pyridine-2-carboxylic acid
- Packaging
- 10g
- Price
- $105
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC13136
- Product name
- 5-Chloro-pyridine-2-carboxylic acid
- Packaging
- 25g
- Price
- $210
- Updated
- 2021/12/16
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5-Chloropyridine-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White crystal powder
Uses
5-Chloropicolinic Acid is an inhibitor of dopamine β-hydroxylase and has antihypertensive activity.
Synthesis
89809-64-3
86873-60-1
The general procedure for the synthesis of 5-chloro-2-cyanopyridine-2-carboxylic acid from 5-chloro-2-cyanopyridine was as follows: in a 1000 mL four-necked flask equipped with a stirrer, a thermometer, and a reflux condenser, 5-chloro-2-cyanopyridine (27.7 g, 0.2 mol) and 277 mg of ethanol were added, and the mixture was stirred until it was completely dissolved to form an aqueous solution. Subsequently, 277 mL of 10% NaOH solution was added and the mixture was heated to 90-100 °C and stirred under reflux conditions for 1.5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) [unfolding reagent ratio of butanol-acetic acid-water = 5:2:2], and after confirming the completion of the reaction, the reaction solution was stirred and cooled to room temperature. The pH was adjusted to 2 with 2 N HCl solution and subsequently concentrated under reduced pressure to about 100 mL. Methanol was added to the concentrate to a total volume of 200 mL, and the solid product was collected by filtration after cooling to 0-5 °C. The filtrate was then filtered. The filtrate was concentrated to dryness under reduced pressure and the residue was dissolved in a solvent mixture of 450 mL of dichloromethane and 50 mL of methanol, stirred for 1 hr and then filtered, and the resulting solid was washed with a 10% methanol-dichloromethane solvent mixture. Finally, the solid was dried in a vacuum oven at 60~65°C for 2 h. The white solid intermediate 5-chloropyridine-2-carboxylic acid was obtained as 25.5 g in 81.4% yield.
References
[1] Patent: CN105348187, 2016, A. Location in patent: Paragraph 0014; 0032
[2] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 132
5-Chloropyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloropyridine-2-carboxylic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 5-Chloropyridine-2-carboxylic acid 86873-60-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-04
Shaanxi Dideu New Materials Co. Ltd
- Product
- 5-Chloropyridine-2-carboxylic acid 86873-60-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-04
Henan Fengda Chemical Co., Ltd
- Product
- 5-Chloropyridine-2-carboxylic acid 86873-60-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
86873-60-1, 5-Chloropyridine-2-carboxylic acidRelated Search:
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