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STREPTOKINASE

Product Name
STREPTOKINASE
CAS No.
9002-01-1
Chemical Name
STREPTOKINASE
Synonyms
SK;awelysin;streptase;kabikinase;Dickkopf-1;DKK-1 human;STREPTOKINASE;Plasminokinase;4-Cyclohexylproline;Crude Streptokinase
CBNumber
CB8492124
Molecular Formula
C11H19NO2
Formula Weight
197.27406
MOL File
9002-01-1.mol
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STREPTOKINASE Property

storage temp. 
-20°C
form 
lyophilized powder
Merck 
13,8903
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Safety

Hazard Codes 
B,Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
OB8880000
F 
10-21
HS Code 
3504009000
Toxicity
LD50 oral in mouse: > 10gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S3134
Product name
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
Purity
lyophilized powder, ≥2,000?units/mg solid
Packaging
10000units
Price
$63.9
Updated
2024/03/01
Sigma-Aldrich
Product number
S3134
Product name
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
Purity
lyophilized powder, ≥2,000?units/mg solid
Packaging
50000units
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
S3134
Product name
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
Purity
lyophilized powder, ≥2,000?units/mg solid
Packaging
250000units
Price
$702
Updated
2024/03/01
Sigma-Aldrich
Product number
SRP6211
Product name
DKK-1 human
Purity
recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
Packaging
10μg
Price
$332
Updated
2023/01/07
Sigma-Aldrich
Product number
SRP6211
Product name
DKK-1 human
Purity
recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
Packaging
50μg
Price
$1590
Updated
2023/01/07
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STREPTOKINASE Chemical Properties,Usage,Production

Description

Streptokinase is a protein produced by certain strains of hemolytic group C streptococcus, and it was the first clinically useful fibrinolytic. Unlike other plasminogen activators, streptokinase is not an enzyme and cannot break any bonds in a plasminogen molecule by itself. It forms an equimolecular compound with plasminogen, thus forming a streptokinase–plasminogen complex. In the plasminogenic region of the resulting complex, certain conformational changes lead to a break in a few peptide bonds, and transformation of this complex into a streptokinase–plasmin complex, or free plasmin, which also decomposes fibrin.

Originator

Streptase,Hoechst,France,1970

Uses

This drug has a half-life in the plasma of 15–30 min, and is used intravenously to treat patients with severe, massive pulmonary embolism and thrombus of the veins; it is also used during myocardial infarctions. Recently, a number of streptokinase derivatives have been proposed, in particular acetylated derivatives, which are developed for use as fibrinolytics.

Uses

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare. Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Therapeutic Function

Enzyme

General Description

Streptokinase (Kabikinase, Streptase)is a catabolic 47,000-d protein secreted by group Cβ-hemolyticstreptococci. It is a protein with no intrinsic enzymaticactivity. Streptokinase activates plasminogen toplasmin, a proteolytic enzyme that hydrolyzes fibrin andpromotes the dissolution of thrombi. Plasminogen is activatedwhen streptokinase forms a 1:1 stoichiometric complexwith it. Allergic reactions to streptokinase occur commonlybecause of antibody formation in individuals treatedwith it. Furthermore, the antibodies inactivate streptokinaseand reduce its ability to prolong thrombin time.Streptokinase is indicated for acute myocardial infarction,for local perfusion of an occluded vessel, and before angiography,by intravenous, intra-arterial, and intracoronaryadministration, respectively.

Biochem/physiol Actions

DKK1 (dickkopf WNT signaling pathway inhibitor 1) functions as a pure inhibitor of Wnt signaling, and was identified as an essential factor for head induction during early Xenopus embryogenesis by suppressing Wnt signaling. In skin, this protein plays a role in determining the pigmentation pattern of the human hand. In colon cancer cells, this protein is inactivated by CpG island promoter hypermethylation. Mesenchymal stem cells (MSCs) have an anti-proliferative effect on cancer cells, as they secrete DKK1 which blocks Wnt signaling.

Mechanism of action

Streptokinase is a protein purified from culture broths of group C β-hemolytic streptococci bacteria. Streptokinase contains a single polypeptide chain of 414-amino-acid residues with a molecular weight of 47 kDa. Streptokinase by itself has no intrinsic enzymatic activity. To be active, it must bind with plasminogen to form an activator complex (1:1 complex). This complex then acts to convert uncomplexed plasminogen to the active fibrinolytic enzyme, plasmin. The streptokinase/plasminogen complex not only degrades fibrin clots but also catalyzes the breakdown of fibrinogen and factors V and VII. As a result, streptokinase is considered to be a fibrinnonspecific drug.

Pharmacokinetics

Unfortunately, the half-life of the activator complex is less than 30 minutes, which frequently is too short to completely lyse a thrombus. Anistreplase (APSAC; Eminase) is a 1:1 streptokinase/lysineplasminogen complex that has been acylated with an anisoyl group at the active-site serine within the lysine-plasminogen. Anistreplase is inactive as such, but following complexation with fibrin, the anisoyl group is slowly cleaved, exposing the active site and, thus, leading to degradation of fibrin. The pro-drug nature of anistreplase exhibits an improved pharmacokinetic profile, with anistreplase acting as a semiselective lysis agent at the clot site. The inactivity of the circulating anistreplase also allows this drug to be given as a very rapid intravenous infusion (typically, 30 U over 3–5 minutes). Tissue reperfusion following anistreplase therapy compares favorably to streptokinase because of the extended half-life (90 minutes).

Clinical Use

Fibrinolytic:
Thrombolysis in DVT, PE, acute arterial thromboembolism, acute MI, thrombosed A-V shunts

Side effects

Because it is a foreign protein, streptokinase is associated with significant hypersensitivity reactions. Most people have, at some point in their lives, had a streptococcal infection and, therefore, have developed circulating antistreptococcal antibodies. These antibodies frequently are active against streptokinase as well. The response of the streptokinase to these antibodies can vary widely, from inactivation of the fibrinolytic properties of the protein to rash, fever, and rarely, anaphylaxis. Significant allergic reactions to streptokinase occur in approximately 3% of patients.

Veterinary Drugs and Treatments

Streptokinase may be useful for the adjunctive treatment of serious thromboses. The use of thrombolytics (streptokinase, t-PA) in cats is controversial.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants should not be given with streptokinase.
Heparin infusions should be stopped 4 hours before streptokinase infusion. If this is not possible, protamine sulphate should be used to neutralise the heparin; heparin infusions can be restarted 4 hours post streptokinase infusion followed by oral anticoagulants.

Metabolism

A small proportion of the dose is bound to antistreptokinase antibodies and metabolised with a half-life of 18 minutes, whilst most of it forms the streptokinaseplasminogen activator complex and is biotransformed with a half-life of about 80 minutes.

STREPTOKINASE Preparation Products And Raw materials

Raw materials

Calcium phosphate Cholesterol

Preparation Products

Streptodornase/streptokinase
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STREPTOKINASE Suppliers

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9002-01-1, STREPTOKINASERelated Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE Benzyl isocyanide N-BUTYLISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate Cupric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Tosylmethyl isocyanide SALCOMINE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate TERT-BUTYL ISOCYANIDE Ferric acetylacetonate PHENYLSELENOL METHYL ISOCYANOACETATE Streptodornase/streptokinase,streptokinase/ streptodornase

  • awelysin
  • kabikinase
  • streptase
  • streptococcalfibrinolysin
  • strepto-kinase(enzyme-activating
  • Dickkopf-1
  • Dickkopf-related protein-1
  • DKK-1 human
  • 4-Cyclohexylproline
  • STREPTOKINASE
  • Streptokinase Bulk Solution
  • Crude Streptokinase
  • STREPTOKINASE(Streptokinase)
  • streptokinase from B-hemolytic*streptococcus (lan
  • streptokinase from streptococcus
  • streptokinase from streptococcus hemo-lyticus
  • Kinase (enzyme-activating), strepto-
  • STREPTOKINASE FROM B-HEMOLYTIC*STREPTOCO CCUS (LANCE
  • STREPTOKINASE FROM STREPTOCOCCUS HEMO- LYTICUS, ~2 U/MG*
  • Plasminokinase
  • streptokinase from β-hemolytic streptococcus (lancefield group c)
  • STREPTOKINASE, FROM LANCEFIELD GROUP C STREPTOCOCCUS
  • Recombinant Streptokinase
  • SK
  • strptococcal, fibrinolysin
  • Refined Streptokinase
  • Streptokinase for system suitability CRS
  • Streptokinase from beta-hemolytic Streptococcus (Lancefield Group C)
  • Mouse Dickkopf 1 elisa kit
  • 4-cyclohexylpyrrolidine-2-carboxylicaci
  • STREPTOKINASE USP/EP/BP
  • Streptokinase From β-hemolytic Streptococcus
  • Streptokinase Concentrated Solution
  • Streptokinase， from β-hemolytic Streptococcus (Lancefield Group C)
  • 9002-01-1
  • BioChemical
  • Biochemicals and Reagents
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Blood
  • Proteolytic Enzymes and Substrates
  • Proteolytic Enzymes
  • Clotting Factors
  • Enzymes, Inhibitors, and Substrates
  • Immune Cell Signaling and Blood
  • enzyme
  • Streptokinase Bulk Solution
  • Crude Streptokinase
  • Refined Streptokinase