ChemicalBook > CAS DataBase List > SR 12813
SR 12813
- Product Name
- SR 12813
- CAS No.
- 126411-39-0
- Chemical Name
- SR 12813
- Synonyms
- 1ilh;GW485801;GW 485801;GW-485801;SR12813;SR 12813;SR-12813(GW 485801);SR-12813, PXR agonist;SR12813, 10 mM in DMSO;SR 12813/126411-39-0/98%;SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801
- CBNumber
- CB8497376
- Molecular Formula
- C24H42O7P2
- Formula Weight
- 504.53
- MOL File
- 126411-39-0.mol
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SR 12813 Property
- Melting point:
- 119-121℃
- Boiling point:
- 552.6±50.0 °C(Predicted)
- Density
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: ≥10 mg/mL
- form
- solid
- pka
- 9.95±0.70(Predicted)
- color
- White to off-white
- biological source
- synthetic (organic)
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Safety
- WGK Germany
- 3
- HS Code
- 29319090
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S4194
- Product name
- SR 12813
- Purity
- ≥98%, solid
- Packaging
- 1mg
- Price
- $54.72
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- S4194
- Product name
- SR 12813
- Purity
- ≥98%, solid
- Packaging
- 5mg
- Price
- $192
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 18115
- Product name
- SR 12813
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $86
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18115
- Product name
- SR 12813
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $356
- Updated
- 2024/03/01
TRC
- Product number
- S684280
- Product name
- SR 12813
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
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SR 12813 Chemical Properties,Usage,Production
Uses
SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.
Definition
ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).
Biological Activity
Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
Biochem/physiol Actions
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.
storage
Store at +4°C
SR 12813 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SR 12813 manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- SR 12813 126411-39-0
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17
126411-39-0, SR 12813Related Search:
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