SR 12813

ChemicalBook > CAS DataBase List > SR 12813

Product Name: SR 12813
CAS No.: 126411-39-0
Chemical Name: SR 12813
Synonyms: GW485801;GW 485801;GW-485801;SR12813;SR 12813;SR-12813(GW 485801);SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801;GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor;Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate);[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester;Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester
CBNumber: CB8497376
Molecular Formula: C24H42O7P2
Formula Weight: 504.53
MOL File: 126411-39-0.mol

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SR 12813 Property

Melting point:: 119-121℃
Boiling point:: 552.6±50.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: ≥10 mg/mL
form: solid
pka: 9.95±0.70(Predicted)
color: White to off-white

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Safety

WGK Germany: 3
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4194
Product name: SR 12813
Purity: ≥98%, solid
Packaging: 1mg
Price: $56
Updated: 2024/03/01

Sigma-Aldrich

Product number: S4194
Product name: SR 12813
Purity: ≥98%, solid
Packaging: 5mg
Price: $187
Updated: 2024/03/01

Alfa Aesar

Product number: J67136
Product name: SR 12813
Purity: 98%
Packaging: 10mg
Price: $159
Updated: 2023/06/20

Cayman Chemical

Product number: 18115
Product name: SR 12813
Purity: ≥98%
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 18115
Product name: SR 12813
Purity: ≥98%
Packaging: 50mg
Price: $356
Updated: 2024/03/01

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SR 12813 Chemical Properties,Usage,Production

Uses

SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.

Definition

ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).

Biological Activity

Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

Biochem/physiol Actions

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.

storage

Store at +4°C

SR 12813 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 12813 Suppliers

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126411-39-0, SR 12813Related Search:

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR9009 SR-9243 SR9011 N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine TETRAETHYL METHYLENEDIPHOSPHONATE DIETHYL ALLYLPHOSPHONATE DIMETHYL VINYLPHOSPHONATE METHYLENEDIPHOSPHONIC ACID TETRAMETHYL METHYLENEDIPHOSPHONATE SR 12813 Tetraethyl vinylidene phosphonate, min. 97 % DIETHYL VINYLPHOSPHONATE

SR-12813(GW 485801)

SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801

GW 485801

GW485801

GW-485801

[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester

SR12813;SR 12813

Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester

GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor

Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate)

126411-39-0

C24H42O7P2