SR 12813

Product Name: SR 12813
CAS No.: 126411-39-0
Chemical Name: SR 12813
Synonyms: 1ilh;GW485801;GW 485801;GW-485801;SR12813;SR 12813;SR-12813(GW 485801);SR-12813, PXR agonist;SR12813, 10 mM in DMSO;SR 12813/126411-39-0/98%;SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801
CBNumber: CB8497376
Molecular Formula: C24H42O7P2
Formula Weight: 504.53
MOL File: 126411-39-0.mol

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SR 12813 Property

Melting point:: 119-121℃
Boiling point:: 552.6±50.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: ≥10 mg/mL
form: solid
pka: 9.95±0.70(Predicted)
color: White to off-white
biological source: synthetic (organic)

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Safety

WGK Germany: 3
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4194
Product name: SR 12813
Purity: ≥98%, solid
Packaging: 1mg
Price: $54.72
Updated: 2025/07/31

Sigma-Aldrich

Product number: S4194
Product name: SR 12813
Purity: ≥98%, solid
Packaging: 5mg
Price: $192
Updated: 2025/07/31

Cayman Chemical

Product number: 18115
Product name: SR 12813
Purity: ≥98%
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 18115
Product name: SR 12813
Purity: ≥98%
Packaging: 50mg
Price: $356
Updated: 2024/03/01

TRC

Product number: S684280
Product name: SR 12813
Packaging: 10mg
Price: $65
Updated: 2021/12/16

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SR 12813 Chemical Properties,Usage,Production

Uses

SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.

Definition

ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).

Biological Activity

Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

Biochem/physiol Actions

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.

storage

Store at +4°C

SR 12813 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 12813 Suppliers

China 61 India 1 Switzerland 1 United Kingdom 1 United States 10 Global 74

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

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View Lastest Price from SR 12813 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: SR 12813 126411-39-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

126411-39-0, SR 12813Related Search:

SR-9243 SR 3029 Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR9009 SR9011 TETRAETHYL METHYLENEDIPHOSPHONATE DIETHYL ALLYLPHOSPHONATE DIMETHYL VINYLPHOSPHONATE METHYLENEDIPHOSPHONIC ACID TETRAMETHYL METHYLENEDIPHOSPHONATE SR 12813 Tetraethyl vinylidene phosphonate, min. 97 % DIETHYL VINYLPHOSPHONATE

SR-12813(GW 485801)

SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801

GW 485801

GW485801

GW-485801

[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester

SR12813;SR 12813

Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester

GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor

Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate)

SR-12813, PXR agonist

SR12813, 10 mM in DMSO

1ilh

4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol

SR 12813/126411-39-0/98%

126411-39-0

C24H42O7P2