7-AZAINDOLE-3-CARBOXALDEHYDE

Product Name: 7-AZAINDOLE-3-CARBOXALDEHYDE
CAS No.: 4649-09-6
Chemical Name: 7-AZAINDOLE-3-CARBOXALDEHYDE
Synonyms: 3-ForMyl-7-azaindole;7-azaindole-3-carbaldehyde;3-b]pyridine-3-carbaldehyde;7-AZAINDOLE-3-CARBOXALDEHYDE;3-FORMYL-PYRROLO[2,3-B]PYRIDINE;7-Azazindole-3-carboxyaldehyde.;7-Azaindole-3-carboxaldehyde 97%;3-FORMYL-1H-PYRROLO[2,3-B]PYRIDINE;7-Azaindole-3-carboxaldehyde, >=97%;Pyrrolo[2,3-b]pyridine-3-carboxaldehyde
CBNumber: CB8666424
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 4649-09-6.mol

More

Less

7-AZAINDOLE-3-CARBOXALDEHYDE Property

Melting point:: 216-220 °C
Boiling point:: 379.6±42.0 °C(Predicted)
Density: 1.31
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 6.07±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H6N2O/c11-5-6-4-10-8-7(6)2-1-3-9-8/h1-5H,(H,9,10)
InChIKey: KAIWRKYDYWYFIT-UHFFFAOYSA-N
SMILES: C12NC=C(C=O)C1=CC=CN=2

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 694681
Product name: 7-Azaindole-3-carboxaldehyde
Purity: 97%
Packaging: 1g
Price: $81.5
Updated: 2023/06/20

TRC

Product number: F697200
Product name: 3-Formyl-7-azaindole
Packaging: 1g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 038928
Product name: 1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde
Packaging: 5g
Price: $44
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA16131
Product name: 7-Azaindole-3-carboxaldehyde
Packaging: 2g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: J50912
Product name: 1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde
Packaging: 1g
Price: $10
Updated: 2021/12/16

More

Less

7-AZAINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

Reactant for preparation of:

Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
Inhibitors of BACE-1 activity
Prostate cancer invasion and migration inhibitors
CDK2 kinase inhibitors
Cell division cycle 7 kinase inhibitors
Inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Antidiabetic agents
Inhibitors of brassinin glucosyltransferase

Uses

7-Azaindole-3-Carboxaldehyde is a reagent used in the preparation of biologically active Azaindoles.

Synthesis

271-63-6

64-19-7

4649-09-6

1H-pyrrolo[2,3-b]pyridine (11.80 g, 100 mmol) was suspended in 33% aqueous acetic acid (200 mL) at room temperature, followed by the addition of hexamethylenetetramine (16.8 g, 120 mmol). The reaction mixture was heated to 110-120 °C (oil bath temperature) and stirred continuously at this temperature for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, at which point a large amount of solid precipitated. The suspension was poured into a 2 L beaker containing ice and the reaction flask was rinsed with 50 mL of water. Subsequently, saturated sodium bicarbonate solution was slowly added for neutralization. After completion of neutralization, the solid product was collected by filtration and washed with distilled water. The product was dried in air to give 1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (9.5 g, 65% yield) as a white solid.EI-HRMS analysis results: m/e calculated value C8H6N2O (M+) 146.0480, measured value 146.0478.

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7577 - 7589
[2] Patent: US2006/84674, 2006, A1. Location in patent: Page/Page column 7
[3] Patent: US2004/224973, 2004, A1. Location in patent: Page 32
[4] Chinese Chemical Letters, 2010, vol. 21, # 3, p. 297 - 300
[5] Patent: US2012/245178, 2012, A1. Location in patent: Page/Page column 12

7-AZAINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

7-AZAINDOLE-3-CARBOXALDEHYDE Suppliers

Canada 1 China 141 Germany 1 India 4 Switzerland 1 United Kingdom 4 United States 18 Global 170

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Alfa Chemistry

Tel: +1-5166625404;
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 20405
Advantage: 58

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

Sinova Inc.

Tel: --
Fax: --
Email: sales@sinovainc.com
Country: United States
ProdList: 4009
Advantage: 58

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Chemgenx, LLC

Tel: --
Fax: --
Country: United States
ProdList: 852
Advantage: 60

CiVentiChem

Tel: --
Fax: --
Email: debra@cvchem.com
Country: United States
ProdList: 1340
Advantage: 55

More

Less

View Lastest Price from 7-AZAINDOLE-3-CARBOXALDEHYDE manufacturers

Career Henan Chemical Co

Product: 7-AZAINDOLE-3-CARBOXALDEHYDE 4649-09-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-20

4649-09-6, 7-AZAINDOLE-3-CARBOXALDEHYDERelated Search:

1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 7-AZAINDOLE-3-CARBOXALDEHYDE METHYL 7-AZAINDOLE-3-GLYOXYLATE 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- 5-Benzyloxy-6-azaindole-3-carboxaldehyde Ethanone, 2-bromo-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- Ethanone, 2-chloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) ALFA-OXO-1H-PYRROLO-[2,3B]PYRIDINE-3-ACETIC ACID MONOPOTASSIUM SALT 1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, a-oxo-, ethyl ester 4-BENZOYL-2-METHYL-1-[(7-OXIDO-1H-PYRROLO[2,3-B] PYRIDIN-3-YL)OXOACETYL]-PIPERAZINE Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) SINOVA SL-02580 Ethanone, 2,2,2-trifluoro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- 6-AZAINDOLE-3-CARBOXALDEHYDE 7-AZAINDOLE-4-CARBOXALDEHYDE 7-AZAINDOLE-5-CARBOXALDEHYDE 1-Boc-7-azaindole-3-carboxaldehyde

7-Azazindole-3-carboxyaldehyde.

7-azaindole-3-carbaldehyde

3-ForMyl-7-azaindole

3-FORMYL-1H-PYRROLO[2,3-B]PYRIDINE

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBALDEHYDE

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXALDEHYDE

3-FORMYL-PYRROLO[2,3-B]PYRIDINE

7-Azaindole-3-carboxaldehyde, >=97%

7-AZAINDOLE-3-CARBOXALDEHYDE

1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 3-Formyl-1H-pyrrolo[2,3-b]pyridine

3-b]pyridine-3-carbaldehyde

Pyrrolo[2,3-b]pyridine-3-carboxaldehyde

7-Azaindole-3-carboxaldehyde 97%

1H-pyrrolo[5,4-b]pyridine-3-carbaldehyde

1H-pyrrolo[5,4-b]pyridine-3-carboxaldehyde

2,9-diazabicyclo[4.3.0]nona-2,4,7,10-tetraene-7-carbaldehyde

4649-09-6

4649-9-6

1004-30-2

4649-O9-6

4649/9/6

Heterocycle-Pyridine series

Indole Derivatives

Miscellaneous Reagents

Heterocycles series

Aldehydes

Fused Ring Systems