ChemicalBook > CAS DataBase List > Sodium cloxacillin monohydrate
Sodium cloxacillin monohydrate
Brand Name(s) in US- Product Name
- Sodium cloxacillin monohydrate
- CAS No.
- 7081-44-9
- Chemical Name
- Sodium cloxacillin monohydrate
- Synonyms
- bactopen;Cloxacillin s;staphobristol-250;Cloxacillin sodium;orbeninsodiumhydrate;α-Amino-p-toluic acid;Cloxacillin sodium CRS;Oxacillin EP Impurity E;prostaphlin-amonohydrate;Cloxacillin Sodium(Oral)
- CBNumber
- CB8705413
- Molecular Formula
- C19H19ClN3NaO6S
- Formula Weight
- 475.88
- MOL File
- 7081-44-9.mol
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Sodium cloxacillin monohydrate Property
- Melting point:
- 170℃
- Boiling point:
- 689℃
- Flash point:
- >110°(230°F)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- solid
- color
- White to Orange to Green
- Water Solubility
- Soluble in water
- Merck
- 13,2444
- BRN
- 5403885
- CAS DataBase Reference
- 7081-44-9(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- XH8920000
- HS Code
- 29411099
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C9393
- Product name
- Cloxacillin sodium salt monohydrate
- Purity
- β-lactamase-resistant antibiotic
- Packaging
- 1g
- Price
- $63.8
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 1142005
- Product name
- Cloxacillin sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- BP089
- Product name
- Cloxacillin sodium
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 125MG
- Price
- $230
- Updated
- 2023/01/07
TCI Chemical
- Product number
- C2244
- Product name
- Cloxacillin Sodium Salt Monohydrate
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C2244
- Product name
- Cloxacillin Sodium Salt Monohydrate
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $144
- Updated
- 2024/03/01
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Sodium cloxacillin monohydrate Chemical Properties,Usage,Production
Brand Name(s) in US
Cloxapen, Orbenin, Tegopen
Description
Cloxacillin was synthesized by Beecham Research Laboratories in 1962 starting with 6- aminopenicillanic acid. It was the first semisynthetic penicillin with a halogen atom in the side chain to be used clinically. It shows 5- to 20-fold stronger activity than methicillin and is twice as active as oxacillin against Staphylococcus aureus, including benzylpenicillin-resistant strains. Cloxacillin is highly stable against penicillinase and well absorbed by oral administration. It has been widely used, by oral and intramuscular administration, to treat internal, surgical, gynecological, and other infections caused by both benzylpenicillin-sensitive and benzylpenicillin-resistant bacteria.
Chemical Properties
White or almost white, hygroscopic, crystalline powder.
Uses
Penicillin antibacterial.
Uses
Targets primarily Gram-positive bacteria, especially -lactamase producing Staphylococci
Definition
ChEBI: Cloxacillin sodium monohydrate is an organic sodium salt and a hydrate. It contains a cloxacillin sodium.
brand name
Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).
Contact allergens
Cloxacillin is a semisynthetic penicillin close to oxacillin. It induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin, but not to penicillin. In cutaneous drug reactions such as acute generalized exanthematous pustulosis due to amoxicillin, cross-reactivity is frequent to cloxacillin (personal observations).
Clinical Use
The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.
Safety Profile
Moderately toxic by intraperitoneal, intramuscular, subcutaneous, and intravenous routes. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl-, NOx, Na2O, and SOx.
Veterinary Drugs and Treatments
Cloxacillin is used via intramammary infusion in dry and lactating dairy cattle.
Sodium cloxacillin monohydrate Preparation Products And Raw materials
Raw materials
Acetoxyacetic acid
Sodium 2-ethylhexanoate
Cloxacillin-13C4 SodiuM Salt
Phosphorus pentachloride
o-Toluidine
Preparation Products
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View Lastest Price from Sodium cloxacillin monohydrate manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Sodium cloxacillin monohydrate 7081-44-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥825μg
- Supply Ability
- 1000kg/month
- Release date
- 2021-06-21
Henan Suikang Pharmaceutical Co.,Ltd.
- Product
- Sodium cloxacillin monohydrate 7081-44-9
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 99.0%
- Supply Ability
- 10tons
- Release date
- 2024-05-07
Hangzhou ICH Biofarm Co., Ltd
- Product
- Cloxacillin sodium 7081-44-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 20 tons
- Release date
- 2023-07-13
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