Sodium cloxacillin monohydrate

Brand Name(s) in US

Product Name: Sodium cloxacillin monohydrate
CAS No.: 7081-44-9
Chemical Name: Sodium cloxacillin monohydrate
Synonyms: bactopen;Cloxacillin s;staphobristol-250;Cloxacillin sodium;orbeninsodiumhydrate;α-Amino-p-toluic acid;Cloxacillin sodium CRS;Oxacillin EP Impurity E;prostaphlin-amonohydrate;Cloxacillin Sodium(Oral)
CBNumber: CB8705413
Molecular Formula: C19H19ClN3NaO6S
Formula Weight: 475.88
MOL File: 7081-44-9.mol

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Sodium cloxacillin monohydrate Property

Melting point:: 170℃
Boiling point:: 689℃
Flash point:: >110°(230°F)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: H2O: soluble50mg/mL
form: solid
color: White to Orange to Green
Water Solubility: Soluble in water
Merck: 13,2444
BRN: 5403885
CAS DataBase Reference: 7081-44-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 26-36
WGK Germany: 2
RTECS: XH8920000
HS Code: 29411099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9393
Product name: Cloxacillin sodium salt monohydrate
Purity: β-lactamase-resistant antibiotic
Packaging: 1g
Price: $63.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1142005
Product name: Cloxacillin sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP089
Product name: Cloxacillin sodium
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 125MG
Price: $230
Updated: 2023/01/07

TCI Chemical

Product number: C2244
Product name: Cloxacillin Sodium Salt Monohydrate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: C2244
Product name: Cloxacillin Sodium Salt Monohydrate
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $144
Updated: 2024/03/01

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Sodium cloxacillin monohydrate Chemical Properties,Usage,Production

Brand Name(s) in US

Cloxapen, Orbenin, Tegopen

Description

Cloxacillin was synthesized by Beecham Research Laboratories in 1962 starting with 6- aminopenicillanic acid. It was the first semisynthetic penicillin with a halogen atom in the side chain to be used clinically. It shows 5- to 20-fold stronger activity than methicillin and is twice as active as oxacillin against Staphylococcus aureus, including benzylpenicillin-resistant strains. Cloxacillin is highly stable against penicillinase and well absorbed by oral administration. It has been widely used, by oral and intramuscular administration, to treat internal, surgical, gynecological, and other infections caused by both benzylpenicillin-sensitive and benzylpenicillin-resistant bacteria.

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Penicillin antibacterial.

Uses

Targets primarily Gram-positive bacteria, especially -lactamase producing Staphylococci

Definition

ChEBI: Cloxacillin sodium monohydrate is an organic sodium salt and a hydrate. It contains a cloxacillin sodium.

brand name

Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).

Contact allergens

Cloxacillin is a semisynthetic penicillin close to oxacillin. It induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin, but not to penicillin. In cutaneous drug reactions such as acute generalized exanthematous pustulosis due to amoxicillin, cross-reactivity is frequent to cloxacillin (personal observations).

Clinical Use

The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.

Safety Profile

Moderately toxic by intraperitoneal, intramuscular, subcutaneous, and intravenous routes. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl-, NOx, Na2O, and SOx.

Veterinary Drugs and Treatments

Cloxacillin is used via intramammary infusion in dry and lactating dairy cattle.

Sodium cloxacillin monohydrate Preparation Products And Raw materials

Raw materials

Acetoxyacetic acid Sodium 2-ethylhexanoate Cloxacillin-13C4 SodiuM Salt Phosphorus pentachloride o-Toluidine

Preparation Products

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View Lastest Price from Sodium cloxacillin monohydrate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Cloxacillin Sodium 7081-44-9
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-04

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Sodium cloxacillin monohydrate 7081-44-9
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 10tons
Release date: 2024-05-07

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Sodium cloxacillin monohydrate 7081-44-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥825μg
Supply Ability: 1000kg/month
Release date: 2021-06-21

7081-44-9, Sodium cloxacillin monohydrateRelated Search:

ETHANE Dimethyl fumarate Dimethyl phthalate Oxacillin sodium monohydrate N,N-Dimethylformamide Sodium benzoate 3,4'-DIAMINODIPHENYLMETHANE Dimethyl sebacate Sodium acetate Dimethyl carbonate Dimethyl sulfoxide Sodium hydroxide Sodium bicarbonate Sodium formate Sodium gluconate Chlorodimethylphenylsilane Dimethyl ether Flucloxacillin sodium

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CLOXACILLIN SODIUM SALT MONOHYDRATE

CLOXACILLIN SODIUM SALT HYDRATE

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CLOXACILLIN SODIUM SALT HYDRATE VETRANAL

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CLOXACILLIN SODIUM WHO(CRM STANDARD)

Cloxacillin sodium hydrate

Cloxacillin monohydrate sodium salt

[5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATE

4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chlorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-

Cloxacillin sodium

Sodium 6-[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate

3-(2-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin Sodium

Claxacillin Sodium(Sodium)

Claxacillin Sodium(Compacted)

Clozicillin sodium (oral)

orbeninsodiumhydrate

prostaphlin-amonohydrate

sodiumcloxacillinmonohydrate

staphobristol-250

thyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-,sodiumsalt,monohydrate

Cloxacillin hydrate sodium salt

Cloxacillin Sodium (200 mg)

7-[[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino]-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid sodium salt

Cloxacillin s

(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt, hydrate (1:1:1)

Cloxacillin Sodium(Oral)

sodium (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate

Cloxacilline sodium 1-hydrate

Cloxacillin Sodium Salt Monohydrate&gt

Cloxacillin Sodium Salt Monohydrate Standard

Cloxacillin sodium CRS

Oxacillin EP Impurity E

Sodium cloxacillin monohydrate USP/EP/BP

Cloxacillin sodiumQ: What is Cloxacillin sodium Q: What is the CAS Number of Cloxacillin sodium Q: What is the storage condition of Cloxacillin sodium Q: What are the applications of Cloxacillin sodium

Cloxacillin Sodium Monohydrate (CSX), 95-102%

Cloxacillin Sodium (1142005)

α-Amino-p-toluic acid

(2S,5R,6R)-6-(3-(2-chlorophenyl)-5-Methyl isoxazole-4-formamide)-3,3-twoMethyl-7-oxy-4-sulfur-1-nitrogen bile [3.2.01 Heptane-2-sodium carboxylate hydrate

(2S,5R,6R)-6-(3-2-chlorobenzeneBase)-5-Methylisoxazole-4-formamideBase)-3.3-Dimethyl-7-oxygenation-4-Sulfur-1-nitrogen bicyclic[3.2.0]Seventh of the ten Heavenly StemsAlkanes-2-sodium carboxylate hydrate

Sodium(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylatemonohydrate

Oxacillin Sodium Monohydrate Impurity E as Sodium Salt Monohydrate

Oxacillin Sodium Monohydrate EP Impurity E as Sodium Salt Monohydrate

Cloxacillin sodium hydrate in ACN:H2O (9:1)

C11692100 Cloxacillin sodium monohydrate

Cloxacillin sodium monohydrate, 10 mM in DMSO

7081-44-9

C19H17ClN3O5SNaH2O

C19H17ClN3O5SNaxH2O

C19H17ClN3NaO5SxH2O

C19H19ClN3NaO6S

C19H17ClN3NaO5SH2O

C19H16N3ClO5SNaH2O

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