2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde
- Product Name
- 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde
- CAS No.
- 5604-46-6
- Chemical Name
- 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde
- Synonyms
- 2-amino-4,6-dichloro-5-pyrimid;2-AMINO-4,6-DICHLOROPYRIMIDINE-5-CARBOX&;2-AMINO-4,6-DICHLORO-5-FORMYL-PYRIMIDINE;2-Amino-4,6-dichloropyrimidin-5-formaldehyde;2-AMINO-4,6-DICHLORO-5-PYRIMIDINECARBALDEHYDE;2-AMINO-4,6-DICHLORO-PYRIMIDINE-5-CARBALDEHYDE;2-AMINO-4,6-DICHLOROPYRIMIDINE-5-CARBOXALDEHYDE;2-aMino-4,6-dichloropyridiMidine-5-carbaldehyde;2-amino-4,6-dichloro-5-pyrimidinecarboxaldehyde;2-azanyl-4,6-dichloro-pyrimidine-5-carbaldehyde
- CBNumber
- CB8706470
- Molecular Formula
- C5H3Cl2N3O
- Formula Weight
- 192
- MOL File
- 5604-46-6.mol
2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde Property
- Melting point:
- 208-224 °C
- Boiling point:
- 411.6±55.0 °C(Predicted)
- Density
- 1.688±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder
- pka
- -1.57±0.10(Predicted)
- color
- Pale Yellow
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 5604-46-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 656720
- Product name
- 2-Amino-4,6-dichloropyrimidine-5-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $117
- Updated
- 2023/06/20
- Product number
- A632055
- Product name
- 2-Amino-4,6-dichloro-5-formylpyrimidine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 295362
- Product name
- 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde
- Packaging
- 2g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- V0655
- Product name
- 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 4H30-5-24
- Product name
- 2-Amino-4,6-dichloropyrimidine-5-carboxaldehyde
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Substrate used in the synthesis of an N-terminal surrogate in amino acid and peptide analogues.
Uses
2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde is a substrate used in the synthesis of an N-terminal surrogate in amino acid and peptide analogues.
Synthesis
56-09-7
5604-46-6
Example 1: This example describes the synthesis of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde using 2-amino-4,6-dihydroxypyrimidine as starting material. The procedure was as follows: absolute DMF (210 mL, 1.38 mol) was added dropwise to an ice-cold POCl3 solution (900 mL) over 20 minutes under ice bath conditions. After removal of the ice bath, powdered 2-amino-6-hydroxypyrimidin-4(3H)-one (150 g, 1.17 mol) was added over 20 min. Subsequently, the reaction mixture was heated to 100 °C and the reaction was stirred at this temperature for 3-4 hours. Upon completion of the reaction, the solution was cooled to room temperature and slowly poured into a pre-prepared ice-water mixture (diluted to 10 L from 4 L of crushed ice with water). The resulting aqueous solution was heated to 50 °C and stirring was continued for 2 hours. Finally, the mixture was placed in a refrigerator overnight and the precipitate was collected by filtration and dried to obtain the target product 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (160 g, 71% yield).
References
[1] Patent: US2003/78413, 2003, A1
2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde Suppliers
- Tel
- --
- Fax
- --
- brunschwig@brunschwig.nl
- Country
- The Netherlands
- ProdList
- 4996
- Advantage
- 67
View Lastest Price from 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde manufacturers
- Product
- 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde 5604-46-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-12
- Product
- 2-Amino-4,6-dichloropyrimidine-5-carboxaldehyde 5604-46-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde 5604-46-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02